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Ask HN: Longevity for your parents, what to do?

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Re: Ask HN: Longevity for your parents, what to do?

#51
I got my mother listening to The Drive with Peter Attia. https://peterattiamd.com/podcast/

It's probably her personality type, but she's taken to completely binging the episode archive.

As for your parents (and anyone else honestly): major in the majors and minor in the minors. Get your diet, exercise, and sleep right first. Only then start looking for pills and supplements.

Nothing will be as effective as these three.

Avoid sugar as much as possible, especially liquid sugar (soda, fruit juice, icecream). Do resistance training and zone 2 cardio several days a week. Get blackout curtains.

Re: Ask HN: Longevity for your parents, what to do?

#52
post #19

I think David Sinclair's track record of actually producing meaningful improvements in human longevity is zero. The whole sirtuin thing got big funding from pharma and then totally failed. I would remain very sceptical of what he says, as he definitely talks up his own work as high as it can go and beyond. Personally, I doubt these supplements make any difference. I also doubt that metformin makes a big difference (a…

While my parents have lived reasonably long, my father until 90 and my mother until 86, they have both lost around 4-5 years of life because of illnesses that have been diagnosed much too late.

In both cases they belonged to risk groups for certain illnesses, but I was not aware of this. Now I wish there would have been some resource enumerating risks for older people and how to diagnose early the corresponding illnesses.

For example, my mother was 1. old, 2. woman, 3. taking for many years a medication against high blood pressure, 4. avoiding to eat much salt for fear of raising the blood pressure.

These 4 conditions create a high risk of hyponatremia and/or hypokalemia (too low content in the body of sodium and/or potassium, because they are eliminated too quickly from the body). Both affections are extremely dangerous.

To avoid any problems, it would have been enough if my mother would have made every few months a cheap blood analysis, to determine the sodium and potassium contents in the blood.

My mother actually made frequent enough analyses of the blood and all results had always been perfect. However, after she became seriously ill and eventually the cause was discovered, I have looked at the earlier blood analyses and while they had checked a myriad of other blood components, sodium and potassium had never been measured.

In the case of my father, he had smoked excessively a large part of his life until he has eventually succeeded to quit smoking. He was also overweight.

These 2 conditions together increase a lot the risk of renal cancer. Had we been aware of that, he should have attempted to check periodically for this.

As it was, the cancer was undetected for at least a couple of years, and it was detected only after it produced a bone tumor (the spread of renal cancerous cells to bones is a frequent occurrence), and even that was detected too late, because after a bone fracture, even if the symptoms had been as in a textbook example of bone cancer, some incompetent doctor diagnosed the symptoms as being caused by osteoporosis and arthritis and did not send him to the scintillation analysis that would have diagnosed the cancer immediately. I have also been too trustful and I did not seek a second opinion.

Due to the many cases of erroneous diagnoses, which happen much more frequently with older people, because the doctors tend to attribute any complaints to normal old age instead of sending them to multiple analyses to investigate for the real cause, it is good to seek second opinions whenever there is any doubt.

In conclusion, I believe that it is important to determine for each parent which are the main health risk factors and to test periodically for the most likely of the illnesses that might begin to affect them after a certain age.

Re: Ask HN: Longevity for your parents, what to do?

#53
post #35

Encourage them to walk as much as possible - hopefully daily. Encourage them to shorten their feeding window. Perhaps as small as 4-6 hours but even 8 hours would be a big step up from a (typical) 12 hour feeding window. If you wanted to be more ambitious, any kind of resistance training would be fantastic but not at the expense of the walking. ... I notice you employing a familiar heuristic: "things doctors don't wa…

The problem with what you're suggesting is that proving something improves longevity is really, really hard. If you want to find out if something's going to help people live longer, you have to study it for a very long time. And of course given the length of the study and the multitude of other factors that may affect longevity, you'd need to have a huge population of participants in the study.

If there were something that let you live to 200, sure. But trying to answer a question like whether the Mediterranean diet extends life on average by 10% is very, very hard. Even if we had great records of what everyone ate, you'd still have to deal with the fact that people consuming that diet tend to live in the same geographical area and share a lot of other behaviors that could very well affect longevity.

Re: Ask HN: Longevity for your parents, what to do?

#54
post #36
post #17

Smother them with 4 year olds. No, seriously: >> A unique social experiment that brings together elderly people in a retirement community with a group of 4-year-olds. Could this encounter between young and old help transform the lives of the elderly? https://thetvdb.com/series/the-old-peoples-home-for-4-year-o... https://thetvdb.com/series/old-peoples-home-for-4-year-olds https://iview.abc.net.au/show/old-people-s-ho…

I was always struck when I lived in China how young, happy and active the elderly all seemed, even though they were much the same age as elderly folk where I grew up (the UK). I had a feeling it must be at least partly due to their increased role in child rearing among most families. This is partly just traditional Chinese culture but probably also comes in part due to the awful working hours most Chinese people tend…

> China how young, happy and active the elderly all seemed

probably because they haven't been exposed to a lifetime of processed foods like here in the west.

Re: Ask HN: Longevity for your parents, what to do?

#55

Earlier quoted context omitted.

May be because people (at least some) love their parents and miss them when they are gone?

Fair enough, but at some point it is worth asking if their longevity is on their best interest and not on yours. Many old people just want to die since they are not able to take care of themselves, and want to go away with dignity. Their descendants sometimes insist on keeping them chugging along as a weird kind of pet. That is weird and wrong. Just let them go, we are all going the same way anyway.

I agree with the sentiment, but I think it's implied in these discussions that they are looking for healthy longevity, not lying in bed unable to take care of oneself for an extra 10 years. It's even in OP's question that they started this research after noticing mental decline so one can reasonably conclude they are looking to halt or reverse the effects.

Re: Ask HN: Longevity for your parents, what to do?

#56
> what to do?

I am 70 and based on my parents and my older siblings I probably have 7 or 8 years left.

Get used to the idea of dying. It's going to happen to you and everyone you know. For the living, quality of life is important. Don't scarifice quality for duration. I want to die before my mind goes. If that means sooner, so be it. When I am dead I won't have regrets, so it's ok.

Re: Ask HN: Longevity for your parents, what to do?

#58
My suggestion: don't fall for super foods or similar promises.

"Dietary supplement companies have aggressively marketed NMN products claiming those benefits"

No single food is a super food.

And yes the hard things are the things which help not the easy things.

Make sure they have good balance, engaging environment and normal health food.

Something plenty of people gave up on

Re: Ask HN: Longevity for your parents, what to do?

#59
post #19

I think David Sinclair's track record of actually producing meaningful improvements in human longevity is zero. The whole sirtuin thing got big funding from pharma and then totally failed. I would remain very sceptical of what he says, as he definitely talks up his own work as high as it can go and beyond. Personally, I doubt these supplements make any difference. I also doubt that metformin makes a big difference (a…

> I think David Sinclair's track record of actually producing meaningful improvements in human longevity is zero.

I know it’s not a great counterpoint but how does he look so young for being in his 50s? He must be doing something that works.

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