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The high-stakes race to engineer new psychedelic drugs

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Re: The high-stakes race to engineer new psychedelic drugs

#171

Post by CameronNemo »

jseliger wrote: post #133
phkahler wrote: post #4

>> As psychedelic therapies for mental health go mainstream, companies are recruiting chemists to create patentable versions of hallucinogens. Same old same old. Let's tweak this molecule to make it "novel" while retaining it's cool properties. Then we can patent it and own the market. In this case they also get the advantage that the existing molecule is illegal.

This may be somewhat difficult, however, given the prior art of Shulgin and others: https://en.wikipedia.org/wiki/TiHKAL . TIHKAL and PIHKAL cover a lot of ground.

The problem is not that we lack patent unencumbered medicine, the problem is that only patent encumbered medicine has the incentives behind it to fund studies into its safety, and the rest of the FDA process.

Re: The high-stakes race to engineer new psychedelic drugs

#173

Post by DJ-P »

throw819352119 wrote: post #66

I have a friend who has severe depression, including self harm and thoughts of suicide. So far guided meditation sessions and antidepressants have had little effect. I have read that some illicit drugs can be effective in treating depression, even after just one or two uses. Can anyone suggest what might be the best option out of ketamine, shrooms, LSD or MDMA?

No post body was provided.

Re: The high-stakes race to engineer new psychedelic drugs

#174

Post by jokowueu »

kennyloginz wrote: post #130
jokowueu wrote: post #105

Earlier quoted context omitted.

I belong to a group where we group our money together to either get the required precursors to make them or hire chemists over seas . It's quite easy but larger quantities are required to bring down the cost There are a lot of other substances as well just recently we were able to procure very cheap rapamycin for people with autoimmune issues If you are interested in joining or just look around reply to me here

How do I join? ( serious question)

https://chat.nootropicsrebirth.com/

After a group buy the admin has his own site where he sells it as well. We had another chemist but he was in Ukraine and is missing currently . He had a huge selection of compounds on his own site .

Admin site : nootropicsfrontline.com

Re: The high-stakes race to engineer new psychedelic drugs

#175

Post by colinmhayes »

mysore wrote: post #28
kodah wrote: post #10

I recently did LSD. It wasn't my first encounter with psychedelics but none have done what LSD did. I have a good bit of trauma that I'd attempted to work through throughout my life. The thing is, many of those things are settled. I cannot change them, I've course corrected my life away from my actions being influenced by these things, and on the exterior I think most people would find me well adapted. I was pretty m…

mdma is generally even more powerful for healing trauma. Or rather MDMA can accelerate healing by released "stored unprocessed memories" LSD can help you by showing you a possibility of whats possible by dissolving the prision of identity and seeing the world from a non-local perspective.

I’ll second this. LSD provides a huge paradigm shift in a way mdma absolutely doesn’t, but if you already know your trauma causes irrational emotions or ones you’d prefer to go away mdma is where to look.

Personally LSD was an eye opening experience, but mdma is the only trip I’ve taken that I can say lead to changes in my perception that I still have to this day.

Re: The high-stakes race to engineer new psychedelic drugs

#176

Post by Zircom »

vorpalhex wrote: post #102
tastyfreeze wrote: post #57

Earlier quoted context omitted.

Shamanic rituals have been the cornerstone of many of the great civilizations of the past. Why are substances that induce introspection and a sense of belonging to something greater than yourself banned?

Sometimes they cause psychotic breaks and Timmy eats off Becca's ear or runs buck naked into the woods and dies. You know, that sorta stuff.

Well today's society causes people to shoot up schools and parades, so frankly biting off an ear sounds pretty preferable.

Re: The high-stakes race to engineer new psychedelic drugs

#177

Post by hiram112 »

astrange wrote: post #166
huetius wrote: post #11

With the collapse of the SSRI hypothesis, I feel like there was a missed opportunity to interrogate what it is about the affluent, technological society that makes such a staggering number of people so depressed. It seems that we will instead (characteristically) plow forward with even more powerful drugs.

Nothing new has happened with SSRIs. Everyone always knew perfectly well they don't work by "raising serotonin levels", but they do still seem to work.

Yeah, I saw a lot of bad takes on Twitter related to the "debunking of the serotonin myth" with the insinuation that they'd finally proven that serotonin itself has absolutely no involvement in depression or anxiety, and it was all just a big hoax perpetrated by Big Pharma.

And then you read an article like this:

> The receptor has proven crucial to understanding the neuropharmacology of the psychedelic experience induced by classical hallucinogens. LSD, mescaline, psilocybin—they all interact with 5-HT2A. (In certain circles, the phrase “5-HT2A agonist” has supplanted “psychedelic”...

5-HT2A receptors, of course, bind to serotonin (or at least that's our primitive theory of what's going on).

We've known for 70 years now that monoamines like dopamine, serotonin, norepinephrine, etc. greatly influence mood. But our model of the brain is primitive, though that doesn't mean our current theories regarding these neurotransmitters like serotonin aren't on the right track.

Re: The high-stakes race to engineer new psychedelic drugs

#178

Post by eurasiantiger »

aaaaaaaaaaab wrote: post #138
nickparker wrote: post #64

Earlier quoted context omitted.

Anyone curious about psychedelic methods of action, particularly based on their personal experience, should read Surfing Uncertainty or at least the SSC review/summary of it. The predictive processing interpretation of these drugs is that they change the balance between top-down predictive generative models from our "deep" brain and noisy bottom-up sensory percepts from the peripheral brain. When you get super-resolu…

This smells like a just-so theory…

This smells drug-naive.

Re: The high-stakes race to engineer new psychedelic drugs

#179

Post by galaxyLogic »

toss1 wrote: post #127
scythe wrote: post #81

Earlier quoted context omitted.

High frequency of use is a necessary condition for addiction.

>>necessary condition for addiction. Necessary, but not sufficient You might also note that the GP said nothing about frequency of use, only "long time psych user", AND that no one here has defined "high frequency" in terms of an actual threshold for addiction. The fact is that for all drugs, and especially for the psychedelics, there are far many more people who use occasionally and responsibly than the subset who a…

I agree. Traveling expands the mind, but you don't want to be traveling all the time. Is travel addictive? Maybe for some but for most of us probably not

Re: The high-stakes race to engineer new psychedelic drugs

#180

Post by galaxyLogic »

labrador wrote: post #2

It's sad that the only way to legalize is to force people to see a qualified therapist and take patented psychedelics in order to benefit from the experience, but that's what the normies want. I've taken them with a therapist and it was meh because the doctor/patient relationship became weird under the influence. On the other hand I've had peak experiences by myself alone in a redwood forest on a fresh clear morning.

> doctor/patient relationship became weird under the influence

That reminds me of a joke, "I said to the doctor, doctor, you got be patient with me"

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