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The high-stakes race to engineer new psychedelic drugs

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Re: The high-stakes race to engineer new psychedelic drugs

#91

Post by zone411 »

zionic wrote: post #37
heap_perms wrote: post #21

Earlier quoted context omitted.

" Talk about missing the forest from the trees. The whole transformative experience is the "trip" itself. " I couldn't agree more. In fact, the trip itself is not a nice side effect, it's the precondition to get measurable, long-term positive changes.

>long-term positive changes. Proponents frequently mention things like this, yet _no one_ who publicly admits to psych use is someone I want to be. All the people I've ever met, and friends who didn't but started down that road, aren't "all there" anymore. They'll preach day and night about the "benefits", but from the outside looking in it's obviously a coping mechanism.

Read a meta study like https://mindmedicineaustralia.org.au/wp-content/uploads/Long.... From section 3.3-3.4, you can see that psychedelic use is beneficial for anxiety and depression and results in improved well-being, increased openness to experience and increased spirituality. Psilocybin-assisted psychotherapy for substance abuse has positive effects. The safety profile shows that they are not risk-free but that there are few negative long-term effects.

Re: The high-stakes race to engineer new psychedelic drugs

#92

Post by s1artibartfast »

NickC25 wrote: post #5

There was an NYT article not too long ago whose entire point is that "true" psychedelic drugs are too dangerous to go mainstream, but isolated chemical compounds that provide some of the chemical effects of LSD / Mushrooms / Ketamine without the "trip" were a much better way to go. The reasoning was that they could engineer a way to chemically induce neuroplastic change in the brain without the liability of visual or…

Seems pretty testable. Co administer the LSD with something to knock out the individual, and ideally prevent them from dreaming.

You could determine if the benifit(s) arise from the the process, experience, and dis/associations of the trip or simply the subconscious biochemical fuckery.

Re: The high-stakes race to engineer new psychedelic drugs

#93

Post by asdff »

engineer_22 wrote: post #43
mathgladiator wrote: post #15

Do we really need new ones? Maybe, we just need to decriminalize nature and let a shamanic class arise to guide us on a spiritual journey of self-awareness.

What could possibly go wrong?

The rituals are already happening. We just choose to ruin people's lives over it.

Re: The high-stakes race to engineer new psychedelic drugs

#94

Post by zone411 »

LocalH wrote: post #72
User23 wrote: post #68

Earlier quoted context omitted.

I know alcoholics who are well to do, out of debt, happily married, and have a diverse social circle and several personal hobbies, get exercise, and enjoy thinking. None of that shows the merits of alcoholism. I can't speak for the person you're replying to, but I could guess that it's your drug addiction that they have no desire to emulate. Addicts insisting that their addiction isn't one is cliché for a reason.

Psychedelics are largely not "addictive". Certainly not physiologically, and almost certainly not mentally.

They actually show promise for stopping additions.

Re: The high-stakes race to engineer new psychedelic drugs

#95

Post by elevaet »

jokowueu wrote: post #87
NickC25 wrote: post #5

There was an NYT article not too long ago whose entire point is that "true" psychedelic drugs are too dangerous to go mainstream, but isolated chemical compounds that provide some of the chemical effects of LSD / Mushrooms / Ketamine without the "trip" were a much better way to go. The reasoning was that they could engineer a way to chemically induce neuroplastic change in the brain without the liability of visual or…

i have tried all the psychadelics that dont provide "trips" . all of them were complete failures yet they show effects on mice for some reason but when did that ever matter. The only interesting one that was impressive was tabernanthalog but even though it didn't produce a twitch response in mice it clearly had a psychadelic effect

How did you end up getting to test tabernanthalog and these other novel compounds?

Re: The high-stakes race to engineer new psychedelic drugs

#96

Post by dmix »

danaris wrote: post #23
NickC25 wrote: post #5

There was an NYT article not too long ago whose entire point is that "true" psychedelic drugs are too dangerous to go mainstream, but isolated chemical compounds that provide some of the chemical effects of LSD / Mushrooms / Ketamine without the "trip" were a much better way to go. The reasoning was that they could engineer a way to chemically induce neuroplastic change in the brain without the liability of visual or…

> Dosing myself in a therapist's office sounds terrifying. The best experience I've ever had was taking a hit of LSD in my living room and spending the day with a pen and paper, writing down thoughts as they came to me. And I personally know people for whom the exact opposite is the case. I'm very much looking forward to the rise of psychedelic therapy.

You mean the isolated subparts right, not actually doing LSD-style drugs in a clinical setting?

Every person I know who had a 'bad trip' did so at a concert or some place they weren't alone or in a quiet area outdoors with close friends (not that there aren't rare exceptions to this rule).

Re: The high-stakes race to engineer new psychedelic drugs

#97

Post by ngold »

NickC25 wrote: post #5

There was an NYT article not too long ago whose entire point is that "true" psychedelic drugs are too dangerous to go mainstream, but isolated chemical compounds that provide some of the chemical effects of LSD / Mushrooms / Ketamine without the "trip" were a much better way to go. The reasoning was that they could engineer a way to chemically induce neuroplastic change in the brain without the liability of visual or…

Couldn't agree more. One of my best trips was in a closet reading Peters principle.

Re: The high-stakes race to engineer new psychedelic drugs

#98

Post by nick__m »

14 wrote: post #45
NickC25 wrote: post #5

There was an NYT article not too long ago whose entire point is that "true" psychedelic drugs are too dangerous to go mainstream, but isolated chemical compounds that provide some of the chemical effects of LSD / Mushrooms / Ketamine without the "trip" were a much better way to go. The reasoning was that they could engineer a way to chemically induce neuroplastic change in the brain without the liability of visual or…

Where does one buy LSD this day and age. Doesn’t seem very popular in my neck of the woods and have not heard anyone having it since I was in high school 20 years ago.

It's been at least decade since I did LSD or it's derivatives but I still read about them and I known that if you live in Canada a search for indole lysergamine and ALD-52[1] should lead you to a shop!

1) https://psychonautwiki.org/wiki/ALD-52

Re: The high-stakes race to engineer new psychedelic drugs

#99

Post by rjbwork »

User23 wrote: post #68
sianemo wrote: post #54

Earlier quoted context omitted.

While I may not be someone you want to be for specific reasons relating to our individuality, I am a long time psych user and I'm demographically and overall culturally someone that is presented as desirable to be. I'm in a reasonably high income percentile, I lack unsecured debt, I'm happily married, I have a diverse social circle and several personal hobbies, I stay physically active, and I enjoy intellectual pursu…

I know alcoholics who are well to do, out of debt, happily married, and have a diverse social circle and several personal hobbies, get exercise, and enjoy thinking. None of that shows the merits of alcoholism. I can't speak for the person you're replying to, but I could guess that it's your drug addiction that they have no desire to emulate. Addicts insisting that their addiction isn't one is cliché for a reason.

The idea of accusing someone of being a drug addict in the context of psychedelic use is absolutely hilarious. You sound completely uninformed and pretty much nobody should take you seriously on this topic.

Re: The high-stakes race to engineer new psychedelic drugs

#100

Post by unethical_ban »

engineer_22 wrote: post #43
mathgladiator wrote: post #15

Do we really need new ones? Maybe, we just need to decriminalize nature and let a shamanic class arise to guide us on a spiritual journey of self-awareness.

What could possibly go wrong?

Freedom is default. Your burden is to explain why an individual can't take a psychedelic drug.
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