Seeds, saplings, etc. Small houseplants and barely sprouted houseplants sell for a lot on Etsy and other sites and require very moderate amounts space and money. The difficulty is skill. Plants can be hard to grow and it’s easy to make a mistake that ruins lots of your crop!
Not spreading plant diseases around ends up being a big deal.
However, the inspection and license is not very hard or expensive.
(My dad grows and sells seedlings of a particular and somewhat obscure native fruit as a side business.)