I think, as a society, we're having trouble grappling with the implications of the hormonal changes that happen due to fat set points increasing over time. It seems to make it nearly impossible for some people to lose weight over a long run of time. Whatever they lose, their body will try very hard, apparently for the rest of their lives, to put it back on.
But what I think we're having trouble in understanding what this means is that it doesn't mean obesity as a social problem can't be solved. It might mean some amount of people who are already obese will never be able to sustainably change that fact, but it's not like people are being born with naturally higher fat set points. That is a hormonal change that happens when you become obese and stay that way for a long time. Interventions that focus on younger people who have not yet become obese can still work. But this is contrary and different to how the entire obesity industrial complex works. It is focused on treating overweight and obese people, not on preventing new people from ever getting that way in the first place. Even with children, we focus the interventions on trying to help fat kids lose weight. We should probably expect that to work at least a little bit better than trying to intervene in adults, but even better still is to work with the kids who aren't obese, which at an early enough age is all of them, and figure out how to keep them that way.