The problem for me, as a long time NYC resident, is that there's no other place in America I want to live even with work from home as a possibility. I like mass transit. I like not owning a car. I like that the city is generally safer than the rest of America. I like that it's the center for tech on the east coast, the arts for the entire country, and finance for most of the world. I like that we generally get along…
Move to SF. Having lived here and Manhattan I think many of the things you like about NY are present here. Just don't listen to the headlines.
Obviously this is all just my opinion! I know tons of people love it there.