The problem for me, as a long time NYC resident, is that there's no other place in America I want to live even with work from home as a possibility. I like mass transit. I like not owning a car. I like that the city is generally safer than the rest of America. I like that it's the center for tech on the east coast, the arts for the entire country, and finance for most of the world. I like that we generally get along…
I discount DC a little because a lot of that is government and defense related (not a bad thing, just not my cup of tea).
Boston has a lot of diversity in tech, lots of health/pharma like Moderna, web companies like TripAdvisor and Wayfair, robotics like Boston Dynamics, tons of startups doing ai/ml, and it seems like every big company has a substantial presence here (Google, Meta, Amazon, Microsoft, Salesforce…)