Earlier quoted context omitted.
While Mithril is interesting unless you are resume-building I'd avoid anything React-like until you are a small team and just go Vanilla JS with events, it can go a long way if you are a solo dev, especially if you have a backend experience and can write clear and simple code.
Can I ask a concrete question: say someone wants to render a table with data coming via an Ajax call to a JSON API. How should they do that with the tools you're suggesting? Use the native JS DOM API to synthesize table rows? (Just in case tone of voice doesn't come across, if that's the solution great, I'm not implicitly criticizing it in advance).
Often people will see this and say "that doesn't scale!" Well, yeah, unless you start writing optimizations, at which point, you maybe created your own framework or view library and maybe you should start looking at something like Preact or Mithril.