So... The downside of eink is: To set a pixel to anything other than white or black requires a distracting and time consuming pattern of white and black flashes. But... There exists multiple different patterns of flashes that end up with the same grey scale shade. So the logical solution seems to therefore be for neighbouring pixels to use different flash patterns such that when viewed from a distance the flashes are…
In Normal/Regal mode, yes, there's a flash as a page is refreshed. This mode should be used only for applications which use page-based (rather than scroll-based) navigation, and which don't have animated elements.
"Speed mode" works exceptionally well for virtually anything else --- most web browsers and even some video, as well as Termux (a terminal-based Linux environment for Android).
The higher-speed modes offer even better refresh rates. The image quality loss / ghosting is only very slightly higher for A2 mode, though for X-Mode it's quite noticeable. The latter is really only for video viewing, or perhaps gaming if that's your thing. Neither of those are uses well-suited to E-ink.
For general reading (PDFs, EPubs, etc.), podcasting (AntennaPod), or web browsing (EinkBro, which is truly awesome, or FennicFox), I prefer e-ink to OLED tablets.