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Great news ! It’s good to know that flu vaccination has two benefits
Correlation is not causation. Ice cream sales don’t cause drowning.
No, but correlation isn't meaningless either. This study [1] appears to be as robust as one can get without doing a double-blind trial. Given the effect size, I suspect that is in the works.
[1] https://content.iospress.com/articles/journal-of-alzheimers-...
People who get yearly flu vaccines probably go to the doctor more regularly than those who do not. I would expect that people who more regularly go to the doctor are also more concerned about their health. I'd expect people who are concerned with their health to behave in ways that limit disease. Without a proposed method of action, I suspect this is just noise.
Never gotten the flu vaccine before. Biggest fear in life is alzheimers. Guess I will get the flu vaccine annually going forward.
This article has very few details and is rather questionable, at best. Correlation does not imply causation. It could very well be that people who choose to get flu vaccines are more health-conscious and live a healthier lifestyle so they are less likely to get Alzheimers.
I don't think the paper or the journal article suggested it was causal either. But such a correlation with such a large population warrants publication and further research into causation.
You unfortunately chose literally the first thing that any epidemiologist would consider, which is considering potential confounders. Maybe read up a bit before commenting.
This article has very few details and is rather questionable, at best. Correlation does not imply causation. It could very well be that people who choose to get flu vaccines are more health-conscious and live a healthier lifestyle so they are less likely to get Alzheimers.
https://content.iospress.com/articles/journal-of-alzheimers-...
People who get yearly flu vaccines probably go to the doctor more regularly than those who do not. I would expect that people who more regularly go to the doctor are also more concerned about their health. I'd expect people who are concerned with their health to behave in ways that limit disease. Without a proposed method of action, I suspect this is just noise.
Related (not exhaustive. The infectious theory is rapidly gaining ground especially in light of anti-beta-amyloid drugs repeatedly failing in clinical trials):
* HSV/Alzheimer's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234998/
* HSV/Alzheimer's: https://content.iospress.com/articles/journal-of-alzheimers-...
* HSV/Alzheimer's: https://pubmed.ncbi.nlm.nih.gov/29488144/ (current independent phase 2 trial to reproduce outcomes: https://clinicaltrials.gov/ct2/show/NCT03282916)
* Gingivitis/Alzheimer's: https://pubmed.ncbi.nlm.nih.gov/32280099/
* Immunological role of Beta-Amyloid: https://alz-journals.onlinelibrary.wiley.com/doi/full/10.100...
People who get yearly flu vaccines probably go to the doctor more regularly than those who do not. I would expect that people who more regularly go to the doctor are also more concerned about their health. I'd expect people who are concerned with their health to behave in ways that limit disease. Without a proposed method of action, I suspect this is just noise.
> 1) influenza-specific mechanisms, including mitigation of damage secondary to influenza infection and/or epitopic similarity between influenza proteins and AD pathology; 2) non–influenza-specific training of the innate immune system; and 3) non–influenza-specific changes in adaptive immunity via lymphocyte-mediated cross-reactivity.
Great news ! It’s good to know that flu vaccination has two benefits
Correlation is not causation. Ice cream sales don’t cause drowning.
And with a proper survey, you can actually account for a lot of these effects. (Ex: after accounting for outdoor temperatures, the Ice Cream Sales / Drowning correlation can be largely factored out).
That there is 40% less incidence in flu vaccinated patients is established by observation, but is it due to flu vaccine by itself or factors which surrounds itself in people more prone to flu or who are medically more conscious? (edit: think of analysis of variance tests among identifiable medical & socioeconomic variables). If the researchers establish a positive link, wouldn't it be worthwhile to then suppose that amyloid plaques are somehow related to viral influenza replication - which by itself sounds a bit absurd (edit: Ok lot of good reference about infections around AD. I take this back, my bad)
The alternative hypothesis is worth thinking too: Are people more prone to Alzheimer's also more prone to catching flu.