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I'm making drugs for cats

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Re: I'm making drugs for cats

#61

My beloved calico who passed away near the beginning of the pandemic suffered from stomatitis. I opted for full dental extraction after pharmaceutical intervention proved ineffective. She eventually passed away from an aggressive mouth cancer, which is not uncommon in cats with stomatitis. I loved that cat, she got me through grad school, and losing her was miserable. My gratitude to anyone working on stomatitis trea…

aggressive mouth cancer? my calico ten years ago succumbed to a horrible oral bone cancer's complications. to hell with cancer, and it's kinda retarded (literal meaning of the word) how slowly progress is made.

Huh? Retarded just means "slow" literally. So, if I get your meaning, it's absolutely not "kinda" retarded, it's depressingly/horribly/saddeningly/hopelessly retarded. And I do not recommend putting "kinda" together with "retarded" if you want to be received positively.

(I'm sorry for what you and your calico endured. F cancer)

Re: I'm making drugs for cats

#62
post #61

Earlier quoted context omitted.

aggressive mouth cancer? my calico ten years ago succumbed to a horrible oral bone cancer's complications. to hell with cancer, and it's kinda retarded (literal meaning of the word) how slowly progress is made.

Huh? Retarded just means "slow" literally. So, if I get your meaning, it's absolutely not "kinda" retarded, it's depressingly/horribly/saddeningly/hopelessly retarded. And I do not recommend putting "kinda" together with "retarded" if you want to be received positively. (I'm sorry for what you and your calico endured. F cancer)

good catch (seriously) of the inadvertent cliche reinforcing "kinda". (yeah eff cancer)

Re: I'm making drugs for cats

#63

My cat got bartonella which caused this condition and had to have all his teeth removed. Prior to the surgery he was in absolute misery, and the only treatment was steroids that did little and aren't meant for longtime use. The surgery was several thousand dollars, out of reach for a lot of families. An effective treatment for this condition would be great!

US I imagine ? It’s a few hundreds here.

Re: I'm making drugs for cats

#64

Just wanted to leave a plea for someone, anyone, to please start working on FeLV and FIV vaccines. Cats normally live 16 years. FeLV/FIV takes them at age 2 or 3. It happened to both of mine. Not only is it common, but it's often assumed that it'll happen. It seems almost lucky when cats don't get it. If an epidemic like that were affecting humans, a trillion dollars would be spent to fight it. But since it's cats, w…

FeLV has a vaccine. Also I guess it’s regional, here not that many cases. Also have personally seen multiple cats live well past 10 with FIV, with no treatment as they are none. 2-3 years seems super short from what I’ve seen so I wouldn’t blame FIV only. (I am an European vet)

Re: I'm making drugs for cats

#65
post #27

If this was published on Medium, I would have highlighted this paragraph: "On the human side, the FDA mostly considers their responsibility to be to stop unsafe or ineffective drugs from entering the marketplace, and believes that allowing safe and effective drugs to enter the marketplace is a secondary goal."

Yep. Not the same in most of EU where proof of efficiency is most often required. Which also explains why some people need to go to the US for treatment

Re: I'm making drugs for cats

#66
post #61

Earlier quoted context omitted.

aggressive mouth cancer? my calico ten years ago succumbed to a horrible oral bone cancer's complications. to hell with cancer, and it's kinda retarded (literal meaning of the word) how slowly progress is made.

Huh? Retarded just means "slow" literally. So, if I get your meaning, it's absolutely not "kinda" retarded, it's depressingly/horribly/saddeningly/hopelessly retarded. And I do not recommend putting "kinda" together with "retarded" if you want to be received positively. (I'm sorry for what you and your calico endured. F cancer)

I mean, it depends on the accent, but some people use "kinda" as a filler word without any strong meaning. I didn't perceive "kinda" to qualify "slow" in that sentence to imply it's "a little slow", given the sentence was written to assert that progress is slow.

Re: I'm making drugs for cats

#67
post #61

Earlier quoted context omitted.

Huh? Retarded just means "slow" literally. So, if I get your meaning, it's absolutely not "kinda" retarded, it's depressingly/horribly/saddeningly/hopelessly retarded. And I do not recommend putting "kinda" together with "retarded" if you want to be received positively. (I'm sorry for what you and your calico endured. F cancer)

I mean, it depends on the accent, but some people use "kinda" as a filler word without any strong meaning. I didn't perceive "kinda" to qualify "slow" in that sentence to imply it's "a little slow", given the sentence was written to assert that progress is slow.

Then just say "kinda slow". Easy. If you want to use a charged word, it's on you to make your intention easily understood. If that's too much for you, then just use a safe and well-understood word.

Re: I'm making drugs for cats

#68
post #49

> I felt good! The next step was in sight: a test of the drug in humans, to see if we actually saw the blood levels of cyclosporine that I expected we would. We had contracted with a CRO in the Netherlands and were raising the $1+ million needed to actually carry out the test when – pop! – the biotech markets imploded. Suddenly, investors literally stopped returning my (and everyone else’s) emails. That sounds like a…

So maybe people should try different markets?

What would be a clever approach to make a drug viable/revenue creating?

Re: I'm making drugs for cats

#69
post #4
post #2

Easier regulatory environments. Not only do you not need to talk to the FDA before testing your drug in animals, cats are way less likely to sue you if they get sick from your drug. Of course, we’d still do our best to make sure they didn’t, but it’s less likely to sink the entire company if they do.

I thought this is paraphrased, but this is lifted straight from the article. This is so incredibly wrong I simply couldn't get past this statement.

How we got to our current state of medicine is horrifying, but the alternative is more grim.

There is no clean arrival for good, safe, effective medicine. A little gallows humor isn't hurting anyone.

Re: I'm making drugs for cats

#70

My cat got bartonella which caused this condition and had to have all his teeth removed. Prior to the surgery he was in absolute misery, and the only treatment was steroids that did little and aren't meant for longtime use. The surgery was several thousand dollars, out of reach for a lot of families. An effective treatment for this condition would be great!

curious, how is your cat doing post-surgery? I imagine it required a significant dietary change
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