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A single prophylactic 200mg dose of Doxycyline prevents Lyme disease

cdc.gov

41–50 of 133 posts

Re: A single prophylactic 200mg dose of Doxycyline prevents Lyme disease

#41
post #27

It's easy for some of us to forget that Lyme disease is an ongoing danger parts of the world. I used to have to keep it in mind when I lived in Tennessee, but that's one thing I don't think about much now that I'm in San Francisco. Of course, I have a lot of other problems instead, just not ticks!

There are ticks and they have lyme disease! https://www.sfchronicle.com/local/environment/article/Lyme-c...

Re: A single prophylactic 200mg dose of Doxycyline prevents Lyme disease

#42
post #19

Earlier quoted context omitted.

I had treatment 100 mg 21 days BID for borreliosis and was careful to always take with a full glass of water, as directed. Only noticeable side effect was affect changes. 9/7 would take that drug again.

Can you elaborate on affect changes? I had a similar regimen and experienced a weird sense of mental clarity and sociability for a couple of weeks after. Never have figured out what the mechanism was.

Look into suramin, pax101 to be specific.

It's being used to treat autism symptoms (social).

Might be a similar mechanism

Re: A single prophylactic 200mg dose of Doxycyline prevents Lyme disease

#44
post #10

Had to take doxycycline for 2 weeks after a tick bite. Man does that stuff destroy your digestive system. 7 years ago was on a date, just casually walking down the street. Coughed a couple times for no particular reason but my doxycycline lined stomach didn’t like that and boom projectile vomiting. Luckily he thought it was funny/ felt bad for me.

I feel you man. I took it for acne for like 3 or so months, and every morning it was a daily battle not to puke my guts out. It didn’t work btw, and I ended up needing accutane, which left my lips ravaged and bleeding for a year.

The sad part is your acne might have been completely fixed solely through dietary intervention.

Re: A single prophylactic 200mg dose of Doxycyline prevents Lyme disease

#45

Not accurate. If you read the original research study this recommendation is based on, it prevents the bullseye rash, which they used as a proxy measure. It's unclear whether or not it actually prevents lyme. I personally got bitten by a tick, did the prophylaxis dose, and then developed joint pain which continued until I did a full 21 day course. Yeah it sucks not being able to go in the sun for an entire month and…

As an outdoorsy person I just want that damn vaccine to come back. Even if its the weird one that is very similar to what you can currently give to your dog it would be a lot better than nothing. Thankfully apparently Lyme either has not or is not common yet in the western US. I'm crossing my fingers we get a new vaccine before it does.

Pfizer and Valneva are working on one: https://www.pfizer.com/news/press-release/press-release-deta...

While the backlash against Lymerix wasn't really deserved, the story around it is somewhat complicated and it wasn't really a great vaccine. (And Lyme seemed to be less of a significant health risk at the time.) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/

Re: A single prophylactic 200mg dose of Doxycyline prevents Lyme disease

#46
post #12

Fascinating. Note that a low-dose daily doxycycline is an effective and common malarial prophylactic as well, with a different (I'd argue less severe) side effect profile than Lariam/Mefloquine.

Is that the one which makes you laconic / home sick / bit nutty?

That's Lariam, yep. I can vouch for "a bit nutty", among other unpleasant mental issues. It's also inexpensive and dosed weekly rather than daily for chemoprophylaxis.

Re: A single prophylactic 200mg dose of Doxycyline prevents Lyme disease

#47
post #29

Is there an app that can alert me when I'm in a tick-infested area? I don't think about ticks living in CA and I'm deadly afraid of being on a vacation and going on a hike and getting bit.

We definitely have ticks with Lyme in CA. I live up north and my county is a bit of a hot spot actually. If you do get bit, don't panic. Typically the tick has to be attached for greater than 24hours before you are at risk since transmission usually occurs when the tick has to regurgitate digested blood back into you. I've been bit too many times to count while surveying and doing site visits to hike creek beds in th…

> regurgitate digested blood back into you.

Ok now i hate ticks even more

Re: A single prophylactic 200mg dose of Doxycyline prevents Lyme disease

#48
post #29

Is there an app that can alert me when I'm in a tick-infested area? I don't think about ticks living in CA and I'm deadly afraid of being on a vacation and going on a hike and getting bit.

The tick-infested area is anywhere with moderately tall grass on the entire eastern half of the United States. I don't think a lot of people realize how bad it's gotten over the past 10-20 years.

Re: A single prophylactic 200mg dose of Doxycyline prevents Lyme disease

#49
post #29

Is there an app that can alert me when I'm in a tick-infested area? I don't think about ticks living in CA and I'm deadly afraid of being on a vacation and going on a hike and getting bit.

Wear long pants and gaiters sprayed with Permethrin. Do tick checks after a hike. Try to avoid unnecessarily walking through long grass. It's not possible to guarantee you won't get a tick on you but you can mitigate a lot of the risk pretty easily. Also, while ticks carry a number of nasties generally, Lyme is specifically about the small deer ticks.

You should be cautious but not "deadly afraid."

Re: A single prophylactic 200mg dose of Doxycyline prevents Lyme disease

#50

Earlier quoted context omitted.

As an outdoorsy person I just want that damn vaccine to come back. Even if its the weird one that is very similar to what you can currently give to your dog it would be a lot better than nothing. Thankfully apparently Lyme either has not or is not common yet in the western US. I'm crossing my fingers we get a new vaccine before it does.

At this point there are so many common tickborne illnesses, plus many that haven't even been discovered, that I don't see having a vaccine against only lyme as being a huge game changer. I mean don't get me wrong, it would be great, but I don't think it would suddenly make it safe to go morel hunting or whatever while wearing shorts. That said, tick bites are mostly avoidable by following the various best practices t…

Tick bites are not mostly avoidable. It is mostly avoidable to have one on you for > 24 hours by checking constantly. Numbers of ticks have increased the past 2 years in my area of NH. I have gotten them walking from my car to the house. Also if you have animals that are treated with tick medicine they bring the ticks inside and then the tick drops off so you can get them in your house.
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