My understanding is that most (or at least many) very significant scientific discoveries were serendipitous. They were discovered while looking for something else. So statements like "When you don’t have much to go on, and limited resources, it’s better to aim at problems that you know are out there. Those things will lead you to new discoveries." don't make sense to me. I'd find this article and its opinion more cre…
Also, there's a mutual relationship between theory and experiment in physics. The LHC was well motivated by theoretical predictions (most notably the Higgs boson) that needed experimental verification. In physics you have to put your theories to the test, otherwise they're not worth much. Each experimental result is like a nail that fixes a part of your theory space (by excluding possible alternative theories), and that then allows you to explore the space further with greater confidence. Hence the more nails, the better.