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Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

pubmed.ncbi.nlm.nih.gov

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Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#61

Post by bradknowles »

danachow wrote: post #60
bradknowles wrote: post #59

Earlier quoted context omitted.

There are alcoholic beers that taste as bad or worse as the non-alcoholic ones. And there are alcoholic drinks that taste like they have no alcohol in them at all. Or drinks where you cannot tell if they have any alcohol in them. There are ways to make these things blinded.

> Or drinks where you cannot tell if they have any alcohol in them. Proving this for a sample is pretty much impossible because you’re simply masking it and the sensory performance of humans is highly variable. You can get some imperfect approximation of blinding but it will be a compromise.

You can still control for this, by having the participants taste both drinks, in a blinded manner.

If they can still somehow taste the difference between them, then you change your mix so that they can't tell the difference or eliminate them from the study.

This may have other effects on the study, but at least you can be reasonably sure that no one can tell the difference between the substances being tested, except possibly by the effects they feel after consuming the substances in question.

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#62

Post by Trouble_007 »

bradknowles wrote: post #61
danachow wrote: post #60

Earlier quoted context omitted.

> Or drinks where you cannot tell if they have any alcohol in them. Proving this for a sample is pretty much impossible because you’re simply masking it and the sensory performance of humans is highly variable. You can get some imperfect approximation of blinding but it will be a compromise.

You can still control for this, by having the participants taste both drinks, in a blinded manner. If they can still somehow taste the difference between them, then you change your mix so that they can't tell the difference or eliminate them from the study. This may have other effects on the study, but at least you can be reasonably sure that no one can tell the difference between the substances being tested, except…

Encapsulated 'freeze dried alcohol' aka 'powdered alcohol'

https://html.duckduckgo.com/html/?q='freeze dried alcohol' '...>

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#63

Post by Trouble_007 »

the_only_law wrote: post #54
0xdeadb00f wrote: post #52

Earlier quoted context omitted.

One not mentioned on this page is dexchlorpheniramine. In my personal experience, exceeding the recommended dose and fighting the drowsiness effect leads to quite a pleasant high and mild aphrodisiac effect.

That’s kinda interesting. I’ve only ever heard of DPH and Doxylamine (which I’ll on occasion use as a terrible sleep aid). I knew other antihistamines exist, but was never curious about their effects.

Added to the information on Antihistamines : https://en.wikipedia.org/wiki/Antihistamine

Prescription Drug Information, Interactions & Side Effects : https://www.drugs.com

drugs.com posted by 'omarhaneef' : https://news.ycombinator.com/user?id=omarhaneef

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#64

Post by 0xdeadb00f »

Trouble_007 wrote: post #56
0xdeadb00f wrote: post #52

Earlier quoted context omitted.

One not mentioned on this page is dexchlorpheniramine. In my personal experience, exceeding the recommended dose and fighting the drowsiness effect leads to quite a pleasant high and mild aphrodisiac effect.

>One not mentioned on this page is dexchlorpheniramine. Yes, I'm afraid the site is not comprehensive, and a bare-bones entry at wikipedia; Dexchlorpheniramine : https://en.wikipedia.org/wiki/Dexchlorpheniramine

Indeed that article is very bare-bones.

I was definitely surprised to find basically nothing about (ab)using dexchlorpheniramine recreationally after noticing the effects over dosing had.

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#65

Post by danachow »

bradknowles wrote: post #61
danachow wrote: post #60

Earlier quoted context omitted.

> Or drinks where you cannot tell if they have any alcohol in them. Proving this for a sample is pretty much impossible because you’re simply masking it and the sensory performance of humans is highly variable. You can get some imperfect approximation of blinding but it will be a compromise.

You can still control for this, by having the participants taste both drinks, in a blinded manner. If they can still somehow taste the difference between them, then you change your mix so that they can't tell the difference or eliminate them from the study. This may have other effects on the study, but at least you can be reasonably sure that no one can tell the difference between the substances being tested, except…

> If they can still somehow taste the difference between them, then you change your mix so that they can't tell the difference or eliminate them from the study.

This has lots of problems, not least of which it is assuming you could afford to tweak your experimental protocol this way all in the recruitment phase.

Do you have any examples in the literature where this is done?

At least for the study in question they used the method of swabbing a negligible amount of alcohol on the rim of the glass to attempt to fool all participants into thinking they were getting alcohol.

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