11–20 of 65 posts
2nd gen antihistamines (Fexofenadine, Cetirizine, Loratidine) are definitely what you want for allergies. 1st gen like Benadryl/Diphenydramine have awful side effects. I highly recommend nasal sprays like Fluticasone as well, available OTC in the US these days and amazing stuff.
2nd gen antihistamines (Fexofenadine, Cetirizine, Loratidine) are definitely what you want for allergies. 1st gen like Benadryl/Diphenydramine have awful side effects. I highly recommend nasal sprays like Fluticasone as well, available OTC in the US these days and amazing stuff.
I would argue that, whatever “generation” it is, cetirizine does not deserve credit for being second generation. I know plenty of people with extremely obvious CNS effects from it. In contrast, loratadine seems innocuous.
50mg diphenhydramine is quite a bit! Anyone who has ever taken that amount for sleep effects will tell you so.
I made that mistake once in university. Took two capsules for a moderate skin reaction and slept the entire afternoon away. Fortunately I was at home! Just willing myself to get up long enough to disrobe and turn the lights off was excruciating.
2nd gen antihistamines (Fexofenadine, Cetirizine, Loratidine) are definitely what you want for allergies. 1st gen like Benadryl/Diphenydramine have awful side effects. I highly recommend nasal sprays like Fluticasone as well, available OTC in the US these days and amazing stuff.
I would argue that, whatever “generation” it is, cetirizine does not deserve credit for being second generation. I know plenty of people with extremely obvious CNS effects from it. In contrast, loratadine seems innocuous.
Earlier quoted context omitted.
I would argue that, whatever “generation” it is, cetirizine does not deserve credit for being second generation. I know plenty of people with extremely obvious CNS effects from it. In contrast, loratadine seems innocuous.
Unfortunately its justifiably classified as 2nd gen and IIRC studies show that it's generally more effective for hay fever. Personally, I've found that loratadine is pretty ineffective, especially after regular use.
Diphenhydramine : https://psychonautwiki.org/wiki/Diphenhydramine
The article is extremely short, but comparing 2-4 OTC doses of diphenhydramine to a level of alcohol concentration above what constitutes a DUI in most places seems like an odd choice? Or is that just a matter of proof of concept, go for the big obvious demonstration first?
2nd gen antihistamines (Fexofenadine, Cetirizine, Loratidine) are definitely what you want for allergies. 1st gen like Benadryl/Diphenydramine have awful side effects. I highly recommend nasal sprays like Fluticasone as well, available OTC in the US these days and amazing stuff.
A corticosteroid, it has awful side effects as well
People forget that drunk driving laws started as the result of activist campaigns from special interest groups only a few decades ago.
It is itself a victimless crime; we have existing laws against reckless driving, causing accidents, vehicular manslaughter, etc.; and as this study shows there are plenty of common, less regulated (i.e. showing no signs of impairment yet blowing into a measurement device cannot get you nailed) driving conditions which are as bad or worse than drunk driving.