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Why is inflammation a dangerous necessity?

quantamagazine.org

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Re: Why is inflammation a dangerous necessity?

#3

An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level. So a ~flatline vs a sinusoid. It could be pharmacologically simulated.

Hormesis and the hygiene hypothesis suggest that "working out" can be good for the immune system too. Unfortunately variolation has become a difficult topic.

Re: Why is inflammation a dangerous necessity?

#4
post #3

An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level. So a ~flatline vs a sinusoid. It could be pharmacologically simulated.

Hormesis and the hygiene hypothesis suggest that "working out" can be good for the immune system too. Unfortunately variolation has become a difficult topic.

I don't think doing exercise trigger an inflammatory (immune) response although I might be wrong. Either way your point stand regarding its paradoxical effect on oxidative stress.

Re: Why is inflammation a dangerous necessity?

#5

An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level. So a ~flatline vs a sinusoid. It could be pharmacologically simulated.

Sounds like exercise or maybe a dry sauna would be a cost effective non pharmaceutical way, short term increase in inflammation that results in a long term decrease in inflammation. Same thing with injuries and fractures but that’s more unrelated.

Re: Why is inflammation a dangerous necessity?

#6
Fun fact. Many autoimmune issues can be triggered / worsened by diet. There is an auto immune protocol diet that is all about reducing inflammation.

Spend a few months on any of the support forms and you’ll see a pattern where people take years to be diagnosed. Most have a mystery illness for several years before it’s diagnosed.

Then they go through years of various medication options with mixed results. Eventually many end up going to diet as a solution.

Many of the various low sugar tend to be fairly close. So a lot of people dealing with autoimmune via diet without realizing it.

Re: Why is inflammation a dangerous necessity?

#8

Fun fact. Many autoimmune issues can be triggered / worsened by diet. There is an auto immune protocol diet that is all about reducing inflammation. Spend a few months on any of the support forms and you’ll see a pattern where people take years to be diagnosed. Most have a mystery illness for several years before it’s diagnosed. Then they go through years of various medication options with mixed results. Eventually m…

I was on the AIP diet for a while, quite a long time ago. It wasn't the end-all solution for me that others proclaimed it was, but it was nice to have something new to try.

Re: Why is inflammation a dangerous necessity?

#9

Fun fact. Many autoimmune issues can be triggered / worsened by diet. There is an auto immune protocol diet that is all about reducing inflammation. Spend a few months on any of the support forms and you’ll see a pattern where people take years to be diagnosed. Most have a mystery illness for several years before it’s diagnosed. Then they go through years of various medication options with mixed results. Eventually m…

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Re: Why is inflammation a dangerous necessity?

#10

An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level. So a ~flatline vs a sinusoid. It could be pharmacologically simulated.

The basal inflammation level is in fact in large part periodic due to the cortisol cycle.
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