Live data from Hacker News

A drug that cures alcoholism may be the next anti-anxiety medication

tus.ac.jp

11–20 of 187 posts

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#11

Antabuse (Disulfiram) does not cure alcoholism. I think there's been a translation error from Japanese to English, because I don't believe the Japanese think they have a cure for alcoholism.

Could it just be a case of an over-enthusiastic headline writer? The article body says "treat" repeatedly; never "cure."

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#12
post #11

Antabuse (Disulfiram) does not cure alcoholism. I think there's been a translation error from Japanese to English, because I don't believe the Japanese think they have a cure for alcoholism.

Could it just be a case of an over-enthusiastic headline writer? The article body says "treat" repeatedly; never "cure."

You're right, misleading headline

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#13
post #7

Given the extremely strong negative reaction to alcohol that patients who are taking Disulfiram experience and given that this is apparently the sole effect that alcohol abuse cessation treatment using it relies on, it is my belief that the treatment is unconscionable and inhumane. I quit drinking after more than 25 years of problematic drinking using naltrexone (The Sinclair Method) and, given my experience with alc…

Antabuse is a way to stop drinking for a period for whatever reason, maybe you have surgery in two weeks and the doctor says you must stop but you can't. No one in danger of having seizures from withdrawels should suddenly stop. I took Antabuse when I wasn't a very bad alcoholic and I stopped for two weeks. Later, when I was much worse, I would shake in the morning until I got a drink. At that point cessation therapy would be dangerous. I did a medical detox.

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#14
I am an alcoholic myself, sober for five months now after a long-term therapy. I am sceptical about taking meds for this desease. The change of life and coping with stress is the best way to avoid getting in relapse of use. The therapists said meds might be a help, but are not the solution. Its a trap for the dependant who might think now hes cured and does not find himself changing his life and solving problems which have caused the desease. I was working in IT and have now time to change, i will be working in a less stressful job and will undergo further treatment of depression and narcicisstic personalty disorder i suffer. In the long run, alcoholism can be avoided by selling it only in special stores, people need more knowledge about it and society itself must be more aware how dangerous alcohol is. I live in bavaria,germany. I can purchase hard liqour around the clock and in amounts with no limit. Its cheap and i have no problem with the people around me. The drinking culture makes it possible to be offerd a beer to almost every occasion. Sure the openly and public drinking in broad daylight is some kind of awkward, but people dont take it too serious. We have no laws exept driving cars or being drunk at the workplace. But well, meds can help a bit to get someone stable enough be treatabel for a long term therapy, but a cure, they are not. The nucleus accumbens has stored the associative information that drinking can help with insomnia, depression and makes live a bit easier. To get rid of this is a long and hard way, the most is done by undergo treatment, self help groups and finding new hobbies or something replacing the habits that led before to the addiction.

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#15

The people I know who like to drink the most are also people I would say are highly anxious, which makes me wonder if they're using alcohol as self medication. Just an informal observation---not claiming a universal truth here.

100% that the folks I know who are alcoholics have high anxiety. It’s not the same exact kind of anxiety in all of them, but I believe it’s at the root of their problem with alcohol. Part of my understanding is that for at least some of these folks they never learned to deal with emotions. They never learned how to feel and accept that feelings exist. Alcohol is the agent that they utilize to help keep those feelings…

You are right with your observations. The root cause are mental health disorders like depression. There is no fast working anti-depressant like alcohol. People try to solve their problems in the short path with it, it works, but in the long run, the problems coming back even more severe. Untreated disorders will be amplified like abuse, depression etc. But its understandable people try alcohol first, until therapy and medication works, its a hard time.

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#18

As I comment on many HN posts, I cannot exaggerate the impact that alcoholism medication has had on my life. It is only tangentially related here, as this comment is not about disulfiram but rather naltrexone, a drug with similar goals but a very different mechanism of action This is all to say, if you or a loved one is struggling with alcoholism, I highly recommend looking into The Sinclair Method. Check out /r/alco…

Good to hear it .. I've been sober 12 years (cold turkey after years of attempts) and when I was struggling I tried to get a prescription for Antabuse and doc said no. I see no reason not to try whatever tools are available to save someone from a terrible life (or death).

Antabuse can lead to death or dangerous healh problems. The doctor is and will be responsible for that, so he wont take the risk.

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#19
post #7

Given the extremely strong negative reaction to alcohol that patients who are taking Disulfiram experience and given that this is apparently the sole effect that alcohol abuse cessation treatment using it relies on, it is my belief that the treatment is unconscionable and inhumane. I quit drinking after more than 25 years of problematic drinking using naltrexone (The Sinclair Method) and, given my experience with alc…

As long as it's voluntary, it should remain a tool for those who choose to use it.

I don't like the idea of court compelled psychiatric or addiction treatment possibly putting people in situations where they might have to take it or otherwise be considered non-compliant to the courts.

The Marchman Act in Florida is particularly worrying in that aspect, as it doesn't require someone to have committed a crime at all to be involuntarily ordered into rehab, and non-compliance can mean being in contempt of court.

It's cliche, but it reminds me a little too much of the Ludovico technique.

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#20
post #14

I am an alcoholic myself, sober for five months now after a long-term therapy. I am sceptical about taking meds for this desease. The change of life and coping with stress is the best way to avoid getting in relapse of use. The therapists said meds might be a help, but are not the solution. Its a trap for the dependant who might think now hes cured and does not find himself changing his life and solving problems whic…

Multiple studies have shown that alcohol sits in the top two of most destructive harddrugs for both the user and the user's surrounding. And still we can buy it everywhere.

Like you say: the drinking culture must change.

Post reply on HN