Earlier quoted context omitted.
> Software still has the lowest marginal cost... I invite you to switch sectors to the pharma world. I worked on a program for a drug planned to be sold at $2,000/dose with a projected cost of $0.0025/dose. That figure included amortization for all the manufacturing equipment, QC etc and raw materials.
Having friends in pharma too, I never hear anything about the commercial end that I don't find disgusting. I get that like any business the goal is maximizing wealth, but feeling empathy for the "customer" makes the margins and decisions seem sickening. Honestly, the idealist in me says healthcare/pharma/research should be publicly owned and operated.
And that one successful medication has to pay for all the trials of all the other candidates that didn't make it... and all the low hanging fruits have long been picked. What is remaining now is stuff for rare viral diseases (not just Covid vaccines that work effectively against mutations, but also HIV, Ebola and similars), cancers and multi-resistant bacteria. All of this has been going on for decades and news of actual marketable products are much rarer than news about promising cancer or whatever treatment ideas.
Everyone loves to dunk on pharma (with reasons, see e.g. Skhreli or the bullshit regarding insulin patents), but the core problem is the sheer cost associated with developing pharmaceuticals.