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Ask HN: Beating depression with or without anti-depressants?

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Re: Ask HN: Beating depression with or without anti-depressants?

#41
I have always had anxiety and catastrophic thinking that then spirals into depression, but a few years back it became so acute I had trouble eating and sleeping which only made my anxiety and depression worse. I had to do something and sought a prescription and was given Escitalopram. It worked really well for me, but there were side effects and I weaned myself off after about a year. There were some minor withdrawal symptoms, but nothing that made it more difficult to stop taking the drugs. Even with the side effects I would do it again. It got me through a rough patch in my life and now I know there is an option if my anxiety ever gets bad again.

If your depression is causing a lack of sleep or other unhealthy habits that can exacerbate depression and anxiety it is worth talking to a doctor to see what your prescription options are.

Re: Ask HN: Beating depression with or without anti-depressants?

#42
Also, quick disambiguation for you, and/or anyone who stumbles on this in the future who may be looking for help:

- PsychOLOGIST: therapy, talk, feelings

- PsychIATRIST: drugs, neurotransmitters, ECT, TMS, etc.

If your neurological chemistry isn't working right in the first place, no amount of therapy is ever going to help you. That's when you go for the drugs through a qualified psychiatrist. Once that's in place, THEN you go see a psychologist for therapy on a regular basis, both to mend the damage long-term and hopefully help you establish the tools necessary to prevent it happening again. But if your brain is fundamentally jacked up because it doesn't have the right balance of neurotransmitters in there, nothing that therapist does is going to matter. So if you tried therapy and nothing's moving the needle, talk to a pschiatrist to see if medication is a good option in your case.

Above all, remember that his is medical science, not witchcraft. We're still learning about how the brain works, but it isn't casting bones or shaking a magic 8 ball either. There's a surprisingly strong amount of science backing this stuff, especially when you consider the human brain as a quantum computing device that is both affected by, and can affect, its own neurotransmitters on an internal and external basis simultaneously. (And that's just the tip of the neurological complexity iceberg...)

> UPDATE: Since you're worried about the drugs, talk to your psychiatrist about TMS. Short for "transcranial magnetic stimulation", it's an evidence-based treatment that is usually reserved for when the drugs don't work, but if your insurance covers it (assuming you're in the US like me, hope you're better off than that though!), it's a non-drug based therapy that can help. Not guaranteed because everybody's different, but it's worth a discussion at the very least. > > There's also ECT (electroconvulsive therapy). Yes, electro-shock. No it's not AT ALL like you see in the movies. It's remarkably safe and effective according to what I've read, though not without some risk. You don't want average run-of-the-mill idiots doing it either, and you sure as hell don't want med school students learning on you. But with the supervision of a skilled physician and team, it's helped people where nothing else has. Also worth a discussion with your doctor, though I honestly advise SSRIs first (I'm not a doctor though so take that with a grain of salt). > > Neither of the above relies on medication whatsoever. Both use external energy sources to influence neurological electrical transmission and (hopefully) stimulate production of the same.

Re: Ask HN: Beating depression with or without anti-depressants?

#43
Serotonin reuptake inhibitors are as good as placebo against major depression and, as you have noted, unsafe to use for longer periods. Some people find the emotional blunting effect of these drugs helpful while waiting for the depression to pass, but this merely suppresses one of the less disabling symptoms and does not counteract the condition. SSRIs are not anti-depressants.

Major depression recurred frequently for most of my life and I was suicidal in my 30s. I asked every physician and health professional I could find for advice and was willing to try just about any therapy or treatment. None of them were helpful in the slightest and after a particularly frustrating experience with a useless, hostile, and expensive psychiatrist I gave up on getting any assistance from the health industry.

Since no one was willing to help I needed to figure this out for myself. I read everything I could find about depression that was not overtly pseudoscientific or superstitious, including hundreds of anti-depressant drug trials of wildly varying quality and power. The breakthrough was realizing that major depression is not a disease or "mental illness"; it is in fact adaptive behaviour shared by all mammals which has become maladaptive in humans due to our modern environments and societal interactions being so far removed from the ones our species evolved in.

Mammals cannot prosper under chronically stressful conditions, e.g. many predators or much stronger rivals in our local environment. Chronic stress from such fears and concerns is what triggers the depression, which alters our behaviour primarily by suppressing dopaminergic pathways. This shuts down normal motivated behaviour like the drive to explore our environment or find a mate and makes us stay at home where we feel safest, recuperating as if sick or injured. This is adaptive because it takes the mammal away from the sources of stress. With environmental stress sources gone the depression will slowly pass, and after a while the mammal is ready to leave its nest, making another attempt at living in its natural environment.

Depression has become maladaptive in modern humans because many of our sources of stress are abstract and long-term concerns that cannot be evaded by staying at home in bed: we worry about losing our source of employment, armed conflicts in neighbouring countries, global warming, and how our stock portfolio is doing. Many human disorders (e.g. anxiety) also predispose us to chronic stress and therefore depression. In my case the root cause turned out to be undiagnosed autism spectrum disorder. I can now manage my depression quite well, but I have had to make large sacrifices – like avoiding most normal social interaction – to achieve this.

You may be able to find the solutions you seek if you can learn the reasons why you are depressed.

Re: Ask HN: Beating depression with or without anti-depressants?

#44
I had severe clinical depression in my early 30s, so this comes from experience and is nuanced and effective.

The depression was so bad it profoundly effected my vocabulary and cognitive function.

We're talking a 20 point drop in IQ. I was so deep in the well I no longer had depression but depression had me. I was fortunate to be going to a therapist at the time who recommended I go on anti-depressants and I agreed but I made a deal with him first.

The starting dose he was going to prescribe was something I saw had similar impact to vigorous exercise so I asked if I could try biking every day for the next 4 weeks and if I wasn't better I would start taking anti-depressants.

Because my fathers depression severely negatively and permanently impacted my life I had a pathological talisman to always get out of bed everyday.

I rode a bike every day in the Texas 100 degree heat, a minimum of 16 miles and usually 20, I would drink over a gallon of water on each ride.

I would sing songs from my childhood and pray out loud (I was ~religous at the time) as I rode and talked to myself and about what was happening in my life almost the whole time... while absolutely flogging myself on the bike every day.

There was no affect the first week, no lifting of depression.

On the 8th day I had ~one hour where my mind seemed normal before the veil dropped again.

By the time I went back to the therapist I was myself for all but an hour a day.

If you cannot do such extreme exercise you MUST go on medication (you should almost definitely go on medication, it's nothing to be scared of, many people are on them only short term), regardless you should see a therapist and follow their advice, you must talk through how you got to your current situation and take practical, physical steps to alter your environment. If you try exercise you must make a time gated deal with your therapist then hold yourself strictly to it.

Medication need not be permanent, if you are inside of depression you must get a mental toe hold out through any means necessary so your operating mindset isn't coming from helplessness and emotional poverty.

In addition to medication I would also practice the entire list below:

Non Pharmacological Cognitive Enhancers – Current Perspectives https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573018/

The one caution I have with medication is that in almost all cases it must accompany working/talking through underlying issues with an engaged therapist, otherwise you're cutting your gains way short. Depression in individuals without clear disorders is like anger, your body and mind are telling you that practical things must change.

Re: Ask HN: Beating depression with or without anti-depressants?

#45
post #40

When you start learning how to ride a bike, training wheels help. Once you're comfortable- take the training wheels off.

And also - it's a cliche fucking answer, but make sure you get outside and see some sunlight every day. If you have the time to do it, walk or bike to your destinations instead of taking the car or public transport.

Walking for about an hour a day in the daytime will likely bring you similar mental benefits as strenuous exercise does. And on the plus-side you're not cooped up in a gym like a hamster in a wheel.

Re: Ask HN: Beating depression with or without anti-depressants?

#46
Had Major Depressive Disorder and Generalized Anxiety Disorder for many years.

I went through a couple different psychiatrists and multiple combinations of meds before I found something that was mostly effective and without major side effects for me. Along the way I went through times where I was severely overmedicated and couldn't really function but quickly recognized that and worked with my psychiatrist to move onto another treatment. You have to give stuff a shot and see how it goes for you, chances are the first thing you try is not the thing that's going to work.

The psychiatrist that I stuck with was the one that suggested I should also see a therapist. My take is you need both. I went through a few different therapists before I found one that worked for me. They helped me develop the tools I needed to break out of the cycle and take control of the anxiety and depression.

Ultimately starting to take care of myself physically was the biggest impact and the thing that really got me off the meds and "graduated" from therapy. But I wouldn't have been able to get started on that without the meds and the therapy.

Re: Ask HN: Beating depression with or without anti-depressants?

#47
> For these reasons I am completely shit-scared of them. I see them as my option of last resort but increasingly I feel my options running out.

I was in the same boat.

Don't listen to the haters. Anti-depressants are amazing. Most of the people who 'cured' their depression through some kind of cheap trick turn out to have been self-diagnosed.

Anti-depressants, if dosed and chosen properly, have basically no side effects. The only change is you get to experience life like neurotypical people. So like, exercise is fun, not a form of torture. Emotions are OK, not the harbringers of the apocalypse.

Living with depression is awful, and it almost never goes away. It's also extremely dangerous. Look at the stats: depression is a dangerous medical condition. Anybody telling you to take some herb or read a book is on the level of the people who prescribe smoothies to cancer patients. Get medical advice. Take drugs if they are prescribed. Depression massively increases your risk of death from all causes. Anti-depressants have like, a slight chance of causing dry skin.

Re: Ask HN: Beating depression with or without anti-depressants?

#48
When I had depression, I had similar symptoms like you. I had same deep pit in the morning and unable to sleep at night.

I tried exercise, read Feeling Good book, took different vitamins etc. None of this really helped.

What finally worked was giving into my depression. I would come back from work, listen to sad songs, cry like a child, pray, and drink until I passed out. Within a few days, I would wake up without pit in my stomach. Hangover was another story. Within a couple of weeks, I was not depressed. Depression turned into anxiety. And anxiety was a lot easier to deal with than depression.

Once depression was mostly gone, then I was able to use CBT methods to deal with my anxiety.

It is really hard for people who never experienced depression to understand what it feels like. It is worse than hell. I am sorry you are going through it. Just take one day at a time.

Re: Ask HN: Beating depression with or without anti-depressants?

#49
I've found very deep breathing exercises have helped me in the past. I highly suggest the Wim Hof method, tied to cold therapy. It has helped me avoid negative thoughts, and move away from procrastination. I've found it helpful to also focus on non-digital tasks. step away from tvs, computers, phones, grab a book, sit under the sun. Don't study, play. Sit on the ground. The earth's field is something we often ignore but some studies show it is necessary to reconnect. Your gut is also something I have tired to manage; cut sugars, test your blood for acidity, avoid certain vegetables (The vegetable paradox), consider parasite management periodically (ivermectin has no side effects), avoid plastics ingestion as much as you can, reduce alcohol as much as you can. This helps. Hope it is something you can try.

Re: Ask HN: Beating depression with or without anti-depressants?

#50

> For these reasons I am completely shit-scared of them. I see them as my option of last resort but increasingly I feel my options running out. I was in the same boat. Don't listen to the haters. Anti-depressants are amazing. Most of the people who 'cured' their depression through some kind of cheap trick turn out to have been self-diagnosed. Anti-depressants, if dosed and chosen properly, have basically no side effe…

This isn’t an accurate description of the possible side-effects. Anti-depressants can cause meaningful side-effects including changes to appetite, difficulty regulating body temperature, nausea, changes to sleep, and akathisia. They are also very, very not fun to quit abruptly if you run into an intolerable side-effect. That said, nothing that you said about depression is wrong and the effects of untreated depression can be far worse than the side-effects of anti-depressants. It can just be hard for people to tell what is normal and what is abnormal and potentially caused by their medication, so they should be informed so that they can switch medication if they run into side-effects. (And know if their doctor is not providing them with good information.)
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