Cholesterol and mortality: Evidence of a U-shape Relationship
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Re: Cholesterol and mortality: Evidence of a U-shape Relationship
#2Can someone tl;dr? Not that the paper is too long, but I think I'd need to go back to university and major in biology or statistics to understand what they discovered and more importantly what it might mean.
Re: Cholesterol and mortality: Evidence of a U-shape Relationship
#3Can someone tl;dr? Not that the paper is too long, but I think I'd need to go back to university and major in biology or statistics to understand what they discovered and more importantly what it might mean.
When you have TC (total cholesterol) When you have TC > 200 mg/dL - each 1mmol/L increases mortality.
The confidence interval was high.
> In the age groups of 18–34, 35–44, 45–54, 55–64, 65–74, and 75–99 years, each 1 mmol/L higher TC increased mortality by 14%, 13%, 8%, 7%, 6%, and 3%, respectively (P < 0.001 for each age group), for TC ≥ 200 mg/dL, while the corresponding TC changes decreased mortality by 13%, 27%, 34%, 31%, 20%, and 13%, respectively, in the range < 200 mg/dL (P < 0.001 for each age group). TC had U-curve associations with mortality in each age-sex group. TC levels associated with lowest mortality were 210–249 mg/dL, except for men aged 18–34 years (180–219 mg/dL) and women aged 18–34 years (160–199 mg/dL) and 35–44 years (180–219 mg/dL). The inverse associations for TC < 200 mg/dL were stronger than the positive associations in the upper range.
Re: Cholesterol and mortality: Evidence of a U-shape Relationship
#4Can someone tl;dr? Not that the paper is too long, but I think I'd need to go back to university and major in biology or statistics to understand what they discovered and more importantly what it might mean.
There exists a non-zero total cholesterol (TC) concentration in blood which is correlated with the minimum all-cause mortality in human beings.
Meaning: lower cholesterol is not always correlated with lower mortality.
Re: Cholesterol and mortality: Evidence of a U-shape Relationship
#5Am I the only one that seems to think there is some correlation is not causation here with the numbers?
Re: Cholesterol and mortality: Evidence of a U-shape Relationship
#6Can someone tl;dr? Not that the paper is too long, but I think I'd need to go back to university and major in biology or statistics to understand what they discovered and more importantly what it might mean.
When you have TC (total cholesterol) When you have TC > 200 mg/dL - each 1mmol/L increases mortality. The confidence interval was high. > In the age groups of 18–34, 35–44, 45–54, 55–64, 65–74, and 75–99 years, each 1 mmol/L higher TC increased mortality by 14%, 13%, 8%, 7%, 6%, and 3%, respectively (P < 0.001 for each age group), for TC ≥ 200 mg/dL, while the corresponding TC changes decreased mortality by 13%, 27%,…
Speculation in the discussion section is that while lower TC (below the limits cited above) is correlated with lower cardiac risk, it seems to be correlated with a higher risk of death. So the implication is there's something else bad for your health about being out of the sweet spot they observed in the data.
Re: Cholesterol and mortality: Evidence of a U-shape Relationship
#7Can someone tl;dr? Not that the paper is too long, but I think I'd need to go back to university and major in biology or statistics to understand what they discovered and more importantly what it might mean.
When you have TC (total cholesterol) When you have TC > 200 mg/dL - each 1mmol/L increases mortality. The confidence interval was high. > In the age groups of 18–34, 35–44, 45–54, 55–64, 65–74, and 75–99 years, each 1 mmol/L higher TC increased mortality by 14%, 13%, 8%, 7%, 6%, and 3%, respectively (P < 0.001 for each age group), for TC ≥ 200 mg/dL, while the corresponding TC changes decreased mortality by 13%, 27%,…
So basically the 170 mg/dL TC limit that my lab shows is very suboptimal, and I should go for 230 instead?
Re: Cholesterol and mortality: Evidence of a U-shape Relationship
#8Earlier quoted context omitted.
When you have TC (total cholesterol) When you have TC > 200 mg/dL - each 1mmol/L increases mortality. The confidence interval was high. > In the age groups of 18–34, 35–44, 45–54, 55–64, 65–74, and 75–99 years, each 1 mmol/L higher TC increased mortality by 14%, 13%, 8%, 7%, 6%, and 3%, respectively (P < 0.001 for each age group), for TC ≥ 200 mg/dL, while the corresponding TC changes decreased mortality by 13%, 27%,…
So basically the 170 mg/dL TC limit that my lab shows is very suboptimal, and I should go for 230 instead?
170 would be in the lowest quartile for American adults, no? Seems like an unreasonable limit.
Re: Cholesterol and mortality: Evidence of a U-shape Relationship
#9Earlier quoted context omitted.
So basically the 170 mg/dL TC limit that my lab shows is very suboptimal, and I should go for 230 instead?
170 would be in the lowest quartile for American adults, no? Seems like an unreasonable limit.
I'm in Greece, but it seems fairly unreasonable here as well. Other labs have the limit at 200 (it varies per lab), but 170 seems too low.
Re: Cholesterol and mortality: Evidence of a U-shape Relationship
#10Earlier quoted context omitted.
When you have TC (total cholesterol) When you have TC > 200 mg/dL - each 1mmol/L increases mortality. The confidence interval was high. > In the age groups of 18–34, 35–44, 45–54, 55–64, 65–74, and 75–99 years, each 1 mmol/L higher TC increased mortality by 14%, 13%, 8%, 7%, 6%, and 3%, respectively (P < 0.001 for each age group), for TC ≥ 200 mg/dL, while the corresponding TC changes decreased mortality by 13%, 27%,…
Speculation in the discussion section is that while lower TC (below the limits cited above) is correlated with lower cardiac risk, it seems to be correlated with a higher risk of death. So the implication is there's something else bad for your health about being out of the sweet spot they observed in the data.
I remember reading about 20 years ago that low cholesterol was correlated with increased mortality due to increased incidence of suicide.