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The Uselessness of Phenylephrine

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Re: The Uselessness of Phenylephrine

#481
post #345

Earlier quoted context omitted.

I could see that problem occurring if the metric was “what is the success rate of everything that Surgeon X does”. I can’t see that problem occurring for “Surgeon X performing Procedure Y has N% of patients reporting relief and M% of patients reporting complications after the surgery”. What am I missing here? Edit: Follow-up question: notwithstanding the dysfunction of congress and the ability of companies to find lo…

I'm guessing you haven't heard of Goodhart's Law? ( https://en.wikipedia.org/wiki/Goodhart%27s_law ) Under your proposal, surgeons will be incentivized to selectively operate on easier patients and minimize their complication rates while not performing surgery on very sick patients who may also need the same surgery. Different surgeons in different areas treat different kinds of patients. It's hard to accurately meas…

No, I haven’t, thanks for mentioning it. Would Goodhart’s Law actually apply here though, since right now the data (as far as I can tell) isn’t being measured at all?

To your counter-example, maybe the metrics I described aren’t good enough and should integrate some disease severity criteria or site-weighting or comorbidity score (although as one continues to subdivide the population this way eventually you end up with n=1 and the results are useless again) but like, surely we should be trying to measure something other than the good feels and word-of-mouth of people who have to work with each other?

It physically hurts my brain when I think about how we measure the dumbest shit in software engineering, like which shade of blue to use to improve clickthroughs[0], but when it comes to even attempting quantification of activities which are literally life or death, sorry, too hard, can’t do it. Surgeons will refuse to do hard procedures, insurers will destroy careers, EMRs are full of bad data (so what is the point of the bloody records if they have become that useless‽), surveying patients would cost too much…

I will ultimately defer to the experience of people in the field—I am not a physician or statistician—but sometimes I feel like I’m just being fed arguments repurposed from the bad cops playbook. Oh, we can’t ever possibly start quantifying individual officers’ use of force, because some parts of the city have more crime, and if we do that then those officers will look worse, so they will stop responding to violent calls in those areas, and there’ll be even more crime, so get off our backs man and stop trying to create more objective metrics for accountability.

To be clear I don’t think you are arguing in bad faith and I don’t intend my statement about accountability to suggest that you personally are trying to avoid it or shield bad actors or anything. What you are saying is probably true and I may be wrong to challenge it at all since I have no personal insight into what is going on behind the scenes, and I genuinely appreciate you answering my questions from your perspective and giving me additional perspectives and things to think about. It just feels so, so frustrating as a patient. All I want is some ability to measure risk that’s better than looking up studies on procedure X on pubmed that I’m unqualified to interpret (and which don’t apply anyway because the lead author of the research won’t be doing my procedure), or shaking the magic eight ball.

If I were a physician, I would absolutely want to track the shit out of my own patient outcomes so I could improve, and the amount of resistance that seems to exist (this is not the first time I’ve talked to docs about this and received similar fatalistic answers) is just baffling to me.

We’re not talking about Frogger here, metrics aren’t some high score, if you have an 80% complication rate for some procedure that isn’t necessarily a reflection on you as a practitioner but it would suggest that there is a problem that needs to be identified (bad procedure, bad training, bad support, bad patient, bad luck). Right now, it seems like no one really knows.

This isn’t bullshit alternative medicine, so why, when I scratch beneath the surface, does it so often feel like it is anyway?

[0] https://www.zeldman.com/2009/03/20/41-shades-of-blue/

Re: The Uselessness of Phenylephrine

#482
post #407

Earlier quoted context omitted.

This is a fallacy. At any point in history you can say “if X field was so good, we’d have Y by now”. In 1925 you could’ve said, “if biology’s understanding of bacteria is so good, we’d have antibiotics by now”. Within 5 years, they did. There is certainly noise in healthcare data especially when patient-reported, but is it noise to say that a patient having X procedure later does or doesn’t have serious complications…

> Big data is coming Big _bad_ data... Let's see how we fare in 5y, then. My prediction as a clinician with a special interest in stats: close to zero medical progress. But insurance priced by a ML algorithm, and much greater efficiency in coverage and claim denials.

Due to the Affordable Care Act (Obamacare), medical insurers have very little flexibility in pricing policies. There's not much point in using ML for pricing.

https://www.healthcare.gov/how-plans-set-your-premiums/

The more likely use case for ML is detecting insurance fraud patterns.

Re: The Uselessness of Phenylephrine

#483
Wait until people find out about the effectiveness of wearing masks on preventing covid infection and spread...

I noticed Phenylephrine didn't work at all for me a handful of years ago after the pseudoephedrine swap occurred. Did a web search and turned up the same info here.

At the time it was amazing to me that these products were being sold.

This is a great article and I applaud the author for trying to get these products pulled or replaced with something effective.

Re: The Uselessness of Phenylephrine

#484

Pseudoephedrine is a stimulant and not a particularly pleasant one at that. Here in Canada there's still cold medicines with it in them, and to be honest, when I see it, I avoid it. It may not be as good of a decongestant but phenylephrine won't keep me up at night. And when I'm sick with a cold what I really need is a good sleep.

Different people are different. It doesn't mess with sleep at all for me. My wife has to use it with care, continued taking of it gives her overdose symptoms. (Obviously, it's not being eliminated as fast as they expect.)

Re: The Uselessness of Phenylephrine

#485
post #300

Earlier quoted context omitted.

The messaging in the US most commonly used to justify the lack of universal coverage and unreasonable cost of care is that we pay the most because we get the best treatments and best doctors and best outcomes, so I don’t think it’s fair to blame laymen for believing that. Also, it’s not just patients that think this way. (Or, at least, if the clinicians know, they aren’t saying much to their patients.) I’ve had docs…

> When I ask for hard data on the surgeon’s actual success rate for this type of surgery, well, they don’t track that—but look, just trust me, the guy’s realllyyy good. For good reason. Tracking of clinical outcomes is the wet dream of insurance companies. It's very toxic to the healthcare system, because it pushes practitioners to focus on easy cases where a good outcome is expected and causes major inequalities in…

> For good reason. Tracking of clinical outcomes is the wet dream of insurance companies.

Sounds like a sufficient reason for single payer healthcare and single payer malpractise compensation even if all the imagined downsides were real.

Re: The Uselessness of Phenylephrine

#486
post #388
post #381

Earlier quoted context omitted.

The intervention-based study (giving patients a controlled dose and measuring the enzyme response) found that over half of study participants will have clinically-significant elevation of ALT at the recommended dose, and 20-30% will have numbers as bad as 5x sustained. Short study aside, that's not what I would personally choose. Remember, there were never Phase trials showing 4g is the right maximum either. It’s jus…

I personally prescribe loads of painkillers, including the whole range of the WHO ladder, and many of those patients have liver tests. It rarely happens that we have to discontinue Tylenol due to hepatitis. I see people on NSAIDs with kidney failure every week. So again yes, Tylenol is toxic. But from personal experience, it's rarely a clinically relevant problem.

Frankly, I'm not sure why NSAIDs are considered the safer option. There was a period of time when I was young, where I had tried various painkillers for treatment of headaches. Every time I had tried an NSAID, my chest felt like it was going to explode, and it became difficult to breathe. Later learned that they may increase the risk of heart attacks and strokes (of which I have a family history). For these reasons, I've sworn to never take them, and only take acetaminophen on rare occasions when pain is bad enough.

Re: The Uselessness of Phenylephrine

#487
post #346

Earlier quoted context omitted.

The messaging in the US most commonly used to justify the lack of universal coverage and unreasonable cost of care is that we pay the most because we get the best treatments and best doctors and best outcomes, so I don’t think it’s fair to blame laymen for believing that. Also, it’s not just patients that think this way. (Or, at least, if the clinicians know, they aren’t saying much to their patients.) I’ve had docs…

Every doctor is the best.

[deleted]

Re: The Uselessness of Phenylephrine

#488
The DEA, FDA, and state regulators are destroying everything IMO. Many doctors don't want to even deal with drugs labeled as a 'controlled substance'.

I ended up going off an extremely effective medication due to none of the doctors (including psychiatrists, etc.) wanting to prescribe it anymore due to restrictions. I now suffer daily. There are a few doctors who will still prescribe it, but predictably, NONE of them take insurance (because they know they can corner the market by not doing so). ALL of them charge $400+ per visit.

Re: The Uselessness of Phenylephrine

#489
post #365

Earlier quoted context omitted.

If data science was that efficient on healthcare records, we'd know it by now and everyone would do it. There is no 'big healthcare data'. We gather mostly noise, and records are full of blatant mistakes. Medicine is still more art than science today, and records mostly give you a 'feeling' for the patient's condition in light of your MD education, with a little hard data sprinkled on top.

My impression is that data science on healthcare records is mostly illegal due to HIPAA and other regulations.

It's not illegal. It's just very complicated to do correctly, and you risk large fines if you do it incorrectly.

Re: The Uselessness of Phenylephrine

#490

Earlier quoted context omitted.

This is very silly, acetaminophen is very effective against pain, and for many people (e.g. me) is tolerated much better, especially at higher doses, than ibuprofen etc. There is already way to much panic about drugs/medicines, especially pain meds, especially especially for chronic conditions, without further hysterics about the 'threat' of useful and well tolerated chemicals. (Not a doctor, not offering medical adv…

I'm not saying it'd be good if acetaminophen got you high, just that one of the reasons it's still OTC is that it doesn't get you high, so there's no one champing at the bit to crack down on it, the way they robbed us of the highly-effective and fairly-harmless pseudoephedrine for the one and only reason that it can be illicitly turned into a street drug.

That's reasonable. My concern is that during my lifetime I have had my access to useful medicines with zero abuse potential restricted because of (imo) panics that it could be turned into street drugs (pseudoephedrine), and also because of panics (imo) that it is too hard on my body (Torodol), and of course because of panics (imo) that they will turn me into a drug addict (opiates). The last class is admittedly worth being cautious about, especially with the more potent forms, but all of these drugs have legitimate medicinal uses and people suffer when they are taken away.

(Also, for drugs that you have to take to get through the day, the lack of a buzz is a definite benefit, and not just because it closes off one argument for restricting them.)

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