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The Uselessness of Phenylephrine

science.org

151–160 of 613 posts

Re: The Uselessness of Phenylephrine

#151
There's only a couple drugs I know by name to look for on package labels and pseudoephedrine is one of them.

The other one is diphenhydramine (an antihistamine i.e. Benadryl) because its common side effect of drowsiness means that its also one of the most common sleep aids. It has been more than once that myself or someone near me was having an allergic reaction and the 7/11 down the block didn't have any Benadryl but did have some sleep aid.

Re: The Uselessness of Phenylephrine

#152
post #42

Earlier quoted context omitted.

For a long time, I've had the idea in the back of my mind that all laws should have expiration dates, and the maximum duration shouldn't be very long (12 or 18 years would be two or three senate terms in the US). Ideally, it would be combined with something to keep the scope of each bill narrow.

It wouldn't work because what would happen would be a mass reapproval of all regulations. What I'd like to see is a constitutional amendment that the total body of federal laws and regulations can't be any longer or more complicated than a person of average intelligence can be taught in a week.

I used to think a limit on the total size of the law like that would be a good idea, but some areas of regulation are inherently complex. I still hold a related position: an adult of reasonable intelligence should be able to easily learn all the laws that they're likely to encounter, and learn which fields are subject to detailed regulation.

To give an example, the regulations governing design of commercial aircraft can almost certainly be simplified from their current state without killing people, but probably cannot be simplified to the point that someone who isn't already an expert on aircraft design can learn them in a week without killing people. Knowing that field is subject to special rules is enough to avoid accidentally violating the regulations.

Re: The Uselessness of Phenylephrine

#153
post #91

Earlier quoted context omitted.

I believe you're just not supposed to drink alcohol on Pseudoephedrine because you'd be combining an upper with a downer, and it's very easy to go overboard with the downers when you're on an upper (tolerance to alcohol increases dramatically and increases overdose risk along with all the other side effects and risks.) So a small amount of alcohol won't really have much of an effect, I'd claim.

In my experiences with old NyQuil it was enough to make you drowsier. And getting to sleep was the primary objective of NyQuil. Back in my college days you could replicate it with one 30mg Sudafed and a shot of Jagermeister. =)

> NyQuil

I don't know about this medication in particular (since I don't live in the US), but I see it contains DXM (dextromethorphan), which is a dissociative (such as ex. ketamine), which probably causes the effects you described. I'm seeing it also contains acetaminophen, which probably makes it hard on your kidneys, if you take too much, so that is probably why people don't abuse it more (I guess or hope).

Re: The Uselessness of Phenylephrine

#154
post #23
post #19

I'm also irked by the fact that OTC cough suppressants like dextromethorphan are equally useless.

Citation? Dextromethorphan works very well for me. (Also DXM is a recreational drug which is why it's always sold OTC with either Tylenol in it or as an extended-release formula)

https://pubmed.ncbi.nlm.nih.gov/11045895/

Re: The Uselessness of Phenylephrine

#155
First, I find that Phenylephrine works well enough as a decongestant for me, without the jitters and heart palpitations. Of course, others' mileage may vary.

Second, how did this sentence:

"There are a number of synthetic procedures for doing this, some of them quite alarming, and several of which can indeed be performed in the barn, garage, basement, or trailer park of your choice..."

make it through editing. This reeks of insensitivity and classism.

Re: The Uselessness of Phenylephrine

#157
I’m skeptical the regulations will ever get rolled back, because it’s just so trivially easy to get spooked by the idea of making meth, but as mentioned in this article, I don’t think pseudoephedrine would become a significant source of methamphetamine again if it was made easily available over the counter.

Because the cartels have gotten really, really good at making meth. Extremely pure and extremely cheap, and the proper psychoactive isomer. There’s a massive supply of cheap and “good” crank out there, so I doubt deregulation of Sudafed would really make a blip in the total supply.

Re: The Uselessness of Phenylephrine

#158
post #19

I'm also irked by the fact that OTC cough suppressants like dextromethorphan are equally useless.

Mucinex (Guaifenesin) fixed all my illness cough problems. It makes your mucus thinner and produces more of it to make your coughs "more productive" which means you finally get that junk out of your throat. Eliminates tickly throat coughs and also is useful in pretty much all situations that involve coughing. It's a genuine magic bullet for me, where no cough suppressant has ever worked, through my entire 30ish year existence.

Re: The Uselessness of Phenylephrine

#159

I've recently had to deal with the medical profession a lot more than in the past and I'm finding this sort of thing everywhere. OTC medicines that by current standards would not be made OTC, surgeries that are extremely common but have never had quality randomized trials, official sounding diagnoses that on inspection are actually defined as "we have no idea", lack of consensus about how to treat some of the most co…

You seem to be under the impression that there is some 'advanced technology' out there that will magically solve your problems that the US fails to have.

In my experience, many people have a quasi-religious belief in the capability of modern medicine to perform what would otherwise be called a miracle. This belief is typically held without any evidence whatsoever.

In reality, there are a plethora of conditions, some very common and serious, that medicine simply has no idea how to treat. The set of completely treatable / curable conditions is much much much smaller than the set of all possible diseases, yet people act as if it's the opposite. This is why things like 'evidence based' medicine is so dangerous -- we don't have evidence for the vast majority of impactful conditions, simply ignoring patients with these conditions is not a workable solution.

Re: The Uselessness of Phenylephrine

#160

First, I find that Phenylephrine works well enough as a decongestant for me, without the jitters and heart palpitations. Of course, others' mileage may vary. Second, how did this sentence: "There are a number of synthetic procedures for doing this, some of them quite alarming, and several of which can indeed be performed in the barn, garage, basement, or trailer park of your choice..." make it through editing. This r…

No, not really. Meth manufacturing is famously a scourge of trailer park communities, where the manufacture itself poses risk to residents that probably outstrip the risks of the drug. Trailers and barns just happen to be an efficient place to stand up makeshift meth labs.
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