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The Uselessness of Phenylephrine

science.org

121–130 of 613 posts

Re: The Uselessness of Phenylephrine

#121
Are there any good decongestants?

Seems like all of them have potentially serious side effects. Pseudoephedrine works but drives up my blood pressure. There are any number of sprays like oxymetazoline but they all create addiction issues if you use them too much.

Re: The Uselessness of Phenylephrine

#122
post #42

Earlier quoted context omitted.

For a long time, I've had the idea in the back of my mind that all laws should have expiration dates, and the maximum duration shouldn't be very long (12 or 18 years would be two or three senate terms in the US). Ideally, it would be combined with something to keep the scope of each bill narrow.

It wouldn't work because what would happen would be a mass reapproval of all regulations. What I'd like to see is a constitutional amendment that the total body of federal laws and regulations can't be any longer or more complicated than a person of average intelligence can be taught in a week.

> It wouldn't work because what would happen would be a mass reapproval of all regulations.

Sunset provisions are an idea I tentatively like until I consider what happens with the fucking stupid, pointless "debt ceiling" crap Congress has decided to make themselves do. I imagine how fun it'd be watching months of idiotic brinksmanship over keeping murder illegal, because one group of legislators wants to grand-stand about abortion. Then repeat for practically everything else.

No thanks.

Re: The Uselessness of Phenylephrine

#123

My drug of choice for colds is NyQuil. It's always been great for opening up my nasal passages enough to let me breathe easily and then knocking me the fuck out so I could sleep off most of the cold. I remember several years ago when all of a sudden NyQuil stopped doing anything useful. I had no idea why but I directly observed that it was like it had been replaced with a non-functioning placebo. Only a couple years…

From what I've read, d-amphetamine[0] was the decongestant of choice for much of the 20th century. It's just that the counterculture weirdos were abusing it and that led to its restriction. Compared to pseudoephedrine its way more useful with minimal side effects like drinking a cup of coffee. [0] https://www.theatlantic.com/health/archive/2012/04/the-lost-...

Counterculture weirdos and Paul Erdos

Re: The Uselessness of Phenylephrine

#124

Pseudoephedrine is wonderfully effective, but beware of its side effects. I used to take it regularly due to congestion related to seasonal allergies, but at a recent medical visit I discovered that my blood pressure had jumped from its usual 120/75 up to 150/105. (My doctor was also alarmed!) I no longer take pseudoephedrine. I'm told that the effect on blood pressure is usually mild, but based on my experience I'd…

How did you control for the pseudoephedrine in this experiment?

Re: The Uselessness of Phenylephrine

#125

Earlier quoted context omitted.

Why not get a non-motorist ID card? Every US state has these; here's Washington's: https://www.dol.wa.gov/driverslicense/gettingidcard.html

I believe this is the key element: > she gave up her license after getting an appointment at the DOL was difficult. I'm not sure what DOL is a reference to; however I now many individuals struggled to get appointments at the Secretary of State (SoS) and that is also where one (at least where I live) would need to get a non-motorist ID. Same amount of frustration / time spent to get a non-motorist ID as it would be to…

DOL ~= DMV = RMV

Re: The Uselessness of Phenylephrine

#126

Sometimes I wonder if NSAIDs are the same deal, or if there's just a subset of people they don't work well on.

NSAIDs and Tylenol definitely work differently on different people and on different types of pain ime. The stronger ones, like Torodol, can be very effective on even quite serious pain, but you can't even get it _with_ a prescription anymore in the USA.

Re: The Uselessness of Phenylephrine

#128
post #57

My drug of choice for colds is NyQuil. It's always been great for opening up my nasal passages enough to let me breathe easily and then knocking me the fuck out so I could sleep off most of the cold. I remember several years ago when all of a sudden NyQuil stopped doing anything useful. I had no idea why but I directly observed that it was like it had been replaced with a non-functioning placebo. Only a couple years…

NyQuil is a combination medicine. The cough, cold and flu formula contains Tylenol (fever/pain reliever), DXM (stops cough) and an antihistamine (dries out your runny nose/postnasal drip). NyQuil can be a great all-in-one product when it's what you need. It's useful to know what it is composed of and why. All of the medicines in it treat symptoms, not the underlying cause, which will be fought off by your immune syst…

Multiple clarifications -

Antihistamines do not directly dry up your runny nose/post nasal drip. Rather, they reduce the histamine response, which is helpful when something is caused by allergies. It's usually not that helpful with an actual cold (but allergic rhinitis is often mistaken for a cold).

Sudafed is what the parent was referring to with Pseudophedrine; a decongestant. This works by shrinking blood vessels, causing swollen passageways to open back up. It doesn't actually do anything to reduce the runny nose or post nasal drip, but by opening the passages more can help them drain more efficiently, preventing that feeling of congestion (hence the name).

Guaifenesin (Mucinex being the name brand) is an expectorant; it causes you to generate more mucus, and reduces the viscosity, allowing you to cough/sneeze/etc your mucus/phlegm based congestion out more easily.

Otherwise I totally agree; it is worth understanding what each of these do so you can pick and choose what you need. Nyquil includes DXM (dextromethorphan) to reduce cough severity, but the acetaminophen is not helpful unless you have a fever or headache, and the Doxylamine Succinate and Phenylephrine (both antihistamines; the Doxyl is added to Nyquil because it's also a sleep aid) aren't particularly helpful unless your cold symptoms are actually allergy related.

Better to buy DXM separately usually; fewer side effects, cheaper, and you can pair it with what else will help you (if you need something to help you sleep, you can add Doxyl or Diphenhydramine if you want; YMMV as to how effective they are)

Don't take Guaifenesin before bed (the increased mucus/phlegm production will make it harder to sleep), but it's good during daytime.

A common side effect of Sudafed is trouble sleeping; if you don't have this side effect it can be helpful in reducing congestion while you try and sleep, but if you do have this side effect, obviously, don't take it before bed.

Re: The Uselessness of Phenylephrine

#130

My drug of choice for colds is NyQuil. It's always been great for opening up my nasal passages enough to let me breathe easily and then knocking me the fuck out so I could sleep off most of the cold. I remember several years ago when all of a sudden NyQuil stopped doing anything useful. I had no idea why but I directly observed that it was like it had been replaced with a non-functioning placebo. Only a couple years…

American law is so disjointed. On one hand, we're decriminalizing drugs. Pot is widely legal now. Other states are allowing mushrooms and LSD. Cocaine and heroin are not legal, but have all but been decriminalized on the West Coast. Meanwhile it's harder than ever to get pain killers from your doctor, even when you have a demonstrated need for them. Same with ephedrine -- a very useful drug -- it's very difficult to…

I just finished reading The Urge: Our history of Addiction. If you're interested in some background on how we got here, the author does a great job of laying out the historical, legal, and social constructs that have resulted in the inconsistent mess.

https://www.harvard.com/book/the_urge/

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