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Rare genital defects seen in sons of men taking major diabetes drug

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Re: Rare genital defects seen in sons of men taking major diabetes drug

#221

Post by chillingeffect »

fleddr wrote: post #220
chillingeffect wrote: post #161

Earlier quoted context omitted.

Youve identified the chain but keep it going: stress and lack of sleep! Ubiquitous coffee, economic pressure, overpriced and weak preventative healthcare system, social pressure, status anxiety, housing insecurity, political threats, public-facing crimes, rampant racism. These all test our self-control around food.

None of those things help, yet none of those things prevent healthy living. For the simple reason that healthy living does not cost a lot of time or money. Like I said, home cook 5-6 days per week, which costs little time or money. None of the issues you mention prevent you from doing it. Exercise costs no money at all. I don't mean to dismiss your reasons as if they don't matter at all, I'm stating they are a trap.…

I agree abt the importance of home cooking, bit if you have a chance, look into how stress affects digestion. The same food can affect the body differently based on its stress state.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#222

Post by zdiscov »

SpodGaju wrote: post #191
macilacilove wrote: post #163

Earlier quoted context omitted.

Type 2 diabetes is not curable with diet. Some (but not all) cases of type 2 can be _prevented_ by proper diet (i.e. avoiding obesity). There is no known diet that cures any type of existing diabetes.

Hmmm. My mother was able to stop taking insulin for her type 2 by changing her diet after doctors told her she would need insulin for the rest of her life. Are you saying it was all in her head? I have no idea why people keep saying this.

Please remember that this changes with age, diet and activity levels. If you can fine tune the diet and monitor glucose levels using CGM/AGM's to precise levels over each and every minute throughout the day/week/years., then it is pretty well possible to get a lot more mileage with the diet alone. Glucose spikes are easy to miss unless monitored this way and could easily be more damaging.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#223

Post by AmericanChopper »

chillingeffect wrote: post #221
fleddr wrote: post #220

Earlier quoted context omitted.

None of those things help, yet none of those things prevent healthy living. For the simple reason that healthy living does not cost a lot of time or money. Like I said, home cook 5-6 days per week, which costs little time or money. None of the issues you mention prevent you from doing it. Exercise costs no money at all. I don't mean to dismiss your reasons as if they don't matter at all, I'm stating they are a trap.…

I agree abt the importance of home cooking, bit if you have a chance, look into how stress affects digestion. The same food can affect the body differently based on its stress state.

There is no digestive condition that causes the body to metabolise more calories than you consume.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#224

Post by strken »

nradov wrote: post #167
strken wrote: post #61

Earlier quoted context omitted.

Why? Playing the devil's advocate here, 42% of the US population is obese right now. Why is it going to be impossible if that hits 60%, or 80%? I ask this as someone with a BMI of 23 who puts a reasonable amount of effort into not becoming obese or overweight again. The personal benefits of not dying from cardiac arrest at 55 are very obvious, but I'm not clear on why healthcare systems won't be able to cope.

Healthcare is already about 20% of the US economy. Where do you think the additional money is going to come from to care for a major increase in diabetics? The rest of the economy doesn't produce enough of a surplus to sustain that.

A huge amount of spending goes towards the healthcare needs of the elderly, and obese people die early. Is there data that suggests increasing obesity increases overall healthcare costs, instead of decreasing them?

I can understand the argument that diabetes resources, specifically, will be strained. If overall costs don't rise, that's not a huge problem.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#225

Post by robbiep »

nradov wrote: post #30
robbiep wrote: post #27

Earlier quoted context omitted.

It is also beginning to be prescribed by many of the subscription medication/doctor businesses that are springing up, powered by VC cash and looking to build strong forward flowing subscription businesses. Their model is: - find areas that aren’t medically serious (speaking relatively, and in relation to life threatening - erectile dysfunction and male pattern baldness) - run people through online questionnaires - ge…

I expect those guys will start pushing SGLT2 inhibitors (gliflozins) next.

I just discovered that apparently that is exactly what they’re doing, not metformin presently. And there a planned shift to GLP1s - but the injectables present some interesting administration aspects

Re: Rare genital defects seen in sons of men taking major diabetes drug

#226

Post by carlmr »

tssva wrote: post #166
carlmr wrote: post #144

Earlier quoted context omitted.

From the quote it says they only adjusted for age and smoking.

The quote says the factors included age and smoking not that they only included age and smoking.

I did indeed not read that properly. I'd have to check the actual publication. It's at least suspicious that they don't mention it, since obesity is probably the first thing you should think of when saying diabetes.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#227

Post by chiefalchemist »

woodruffw wrote: post #7
chiefalchemist wrote: post #6

> "...because tens of millions of people worldwide take metformin, chiefly for type 2 diabetes." In nearly all cases, T2 is preventable. That is, unlike T1, there are things an individual can do to not reach T2.

On a micro level, most cases of T2 are preventable. On the macro level, many aren't: food deserts have higher rates of diabetes and heart disease, and the people who live in those areas are frequently "stuck" there for socioeconomic and racial reasons. There are also subgroup susceptibilities in play: Asians and people with Hispanic backgrounds are disproportionately represented among American T2 diabetics[1]. Recent…

Yes. But again...food deserts - in the country that put a man on the moon - certainly solvable. And certainly such efforts are more ethical than rolling genetic defect dice. But we're led to believe it's Big Pharma or nothing? That's an injustice to Truth.

https://www.ted.com/talks/ron_finley_a_guerrilla_gardener_in...

Re: Rare genital defects seen in sons of men taking major diabetes drug

#228

Post by hirundo »

mikeyouse wrote: post #198
giantg2 wrote: post #158

Earlier quoted context omitted.

Literally, the root(?) commenter said diet was not discussed. They had to find out about a low carb diet on their own, and it worked.

Sure, but that's almost certainly an exaggeration where OP gets to cosplay as the 'hero' in their story -- every single treatment protocol in every single medical setting for diabetes starts with a low-carb diet and exercise. Literally the top of the 'treatment' section on WebMD: > Managing type 2 diabetes includes a mix of lifestyle changes and medication. Lifestyle changes: You may be able to reach your target bloo…

It was not an exaggeration. I was morbidly obese at the time, and the doctor almost completely ignored that condition for the roughly five years that I saw him. He did once recommend that I always eat a salad at the start of dinner. That was it.

When he saw that I was losing weight and that my A1C was heading downward, he asked what I was doing. I told him about the carb restriction. He looked down, smiled, shook his head, and said nothing. That was the end of it.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#229

Post by nradov »

strken wrote: post #224
nradov wrote: post #167

Earlier quoted context omitted.

Healthcare is already about 20% of the US economy. Where do you think the additional money is going to come from to care for a major increase in diabetics? The rest of the economy doesn't produce enough of a surplus to sustain that.

A huge amount of spending goes towards the healthcare needs of the elderly, and obese people die early. Is there data that suggests increasing obesity increases overall healthcare costs, instead of decreasing them? I can understand the argument that diabetes resources, specifically, will be strained. If overall costs don't rise, that's not a huge problem.

Obese patients on average cost about $2500 per year more than normal weight patients. Even though they die earlier they still increase overall healthcare costs.

https://www.jmcp.org/doi/10.18553/jmcp.2021.20410

Re: Rare genital defects seen in sons of men taking major diabetes drug

#230

Post by mecha_ghidorah »

bsder wrote: post #88
ceeplusplus wrote: post #29

Earlier quoted context omitted.

Prescriptions of diet and exercise are ineffective because many obese / type 2 diabetic people can't exercise self-control. That's why they're obese in the first place. It's way easier to take a pill than cut to 1500 calories a day for 2 years.

> Prescriptions of diet and exercise are ineffective because many obese / type 2 diabetic people can't exercise self-control. That's why they're obese in the first place. Research continues its trend against this statement. 1) One problem is the fact that the number of fat cells in the body is conserved after some point. So, if you grew lots of fat cells as a child, sucks to be you, you're now stuck with them as an a…

> Exercise is practically useless for weight loss. The body demands a fixed number of calories (up until you're doing something at the level of extreme training) and shunts the available calories between systems. Exercise has lots of benefits. Weight loss just isn't one of them.

This is sort of true but also sort of not. The body doesn't require a fixed amount of calories exactly, a specific body composition does. If you put on muscle the amount of calories the body demands goes up.

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