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Rare genital defects seen in sons of men taking major diabetes drug

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Re: Rare genital defects seen in sons of men taking major diabetes drug

#161

Post by chillingeffect »

fleddr wrote: post #134
idorosen wrote: post #40

Earlier quoted context omitted.

It is a harmful stereotype to label obese people as lacking willpower as you have done. Many obese people don’t have the resources (time, money) or tools (nutrition understanding) to improve their situation. Many have metabolic or familial history of obesity which has both physical and psychological (normalization) impact on their ability to control their weight. The former can be helped with diet and/or medication,…

It's much more harmful to obsess over the optics of something potentially offensive at the expense of reality. None of the excuses you listed hold any ground. Time: it costs about 20 minutes to cook a simple, basic fresh meal. With a single weekly groceries delivery (or visit to the store), you're covered for some 5-6 main meals as well as breakfast and lunch. Are you telling me Americans don't have 20 minutes to pre…

Youve identified the chain but keep it going: stress and lack of sleep!

Ubiquitous coffee, economic pressure, overpriced and weak preventative healthcare system, social pressure, status anxiety, housing insecurity, political threats, public-facing crimes, rampant racism. These all test our self-control around food.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#162

Post by ImaCake »

ars wrote: post #72

"The researchers analyzed records from more than 1.1 million babies born in Denmark between 1997 and 2016, using the country’s comprehensive medical registries to connect data on births, paternal metformin prescriptions, and birth defects." Did they look for any defect correlated with any drug? Because if they did, random chance alone would find something. Anyone read the actual study?

I sought it out after seeing this link and found it to be very unimpressive. Science would do well to delete this article spruiking pretty trash science.

P-values seem to be carefully hidden (not in the tables) and as far I could tell were not passing FDR. A lot of models were displayed in various tables and very few of them even had OR CIs that didn't overlap 1.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#163

Post by macilacilove »

eric4smith wrote: post #154

It’s so interesting that type 2 diabetes is curable with diet. Type 1 is incurable. My point is that the psychology of eating is so strong that people would rather take a drug that pass on birth defects to the future than change eating habits. And I’m a person coming from struggling with just those habits. I think if someone could come up with a treatment to adjust mindsets - it would change healthcare forever and en…

Type 2 diabetes is not curable with diet. Some (but not all) cases of type 2 can be _prevented_ by proper diet (i.e. avoiding obesity). There is no known diet that cures any type of existing diabetes.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#164

Post by ridgered4 »

giantg2 wrote: post #21
brenainn wrote: post #19

Earlier quoted context omitted.

One of my scariest adulthood realizations is that doctors are like everybody else; fallible. And that being certified means you're good at studying, but doesn't always mean you're good at what you've studied. Not trying to discredit medical professionals or the amount of work they put in. I'm sure the majority are intelligent, conscientious and good at their jobs.

True, the field is vast. But I expect that a doctor should know the basics of a common condition. If they aren't counseling diabetics about carbs... wtf is going on? It would be different if it were a rare or complex topic, but even then the Epic system that most places use have standard printouts with information for patients.

I don't have a source since I read it in a magazine at a doctors office 10 years ago, but I recall an article about how recommending diet and exercise had no meaningful increase in patients actually doing those things in a study. Combined with some patients being offended by the suggestion, the article made the case to no longer make the recommendation because it didn't work anyway!

Re: Rare genital defects seen in sons of men taking major diabetes drug

#165

Post by eric4smith »

macilacilove wrote: post #163
eric4smith wrote: post #154

It’s so interesting that type 2 diabetes is curable with diet. Type 1 is incurable. My point is that the psychology of eating is so strong that people would rather take a drug that pass on birth defects to the future than change eating habits. And I’m a person coming from struggling with just those habits. I think if someone could come up with a treatment to adjust mindsets - it would change healthcare forever and en…

Type 2 diabetes is not curable with diet. Some (but not all) cases of type 2 can be _prevented_ by proper diet (i.e. avoiding obesity). There is no known diet that cures any type of existing diabetes.

The thing is, Type 2 is not even a disease. Its just an imbalance of glucose. So there is really nothing to cure, its just about bringing back your blood glucose levels in balance so that the liver and pancreas can begin to function correctly again.

Of course there could be irreversible damage to those organs and that would be really bad (Several relatives who died of this).

But you are partly right. There can be remission and back to normal with lifestyle changes and Type 2. Substantial studies and clinical evidence shows this.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#166

Post by tssva »

carlmr wrote: post #144
rat9988 wrote: post #136

Earlier quoted context omitted.

Why would you assume they didn't? They most likely did.

From the quote it says they only adjusted for age and smoking.

The quote says the factors included age and smoking not that they only included age and smoking.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#167

Post by nradov »

strken wrote: post #61
nradov wrote: post #52

Earlier quoted context omitted.

Why was this down voted? You're not wrong. Regardless of whether we have a private or socialized healthcare system, we simply won't be able to afford to continue delivering high quality care to everyone with chronic conditions caused by bad dietary choices and sedentary lifestyle. The resources just aren't there so we will increasingly have to ration care.

Why? Playing the devil's advocate here, 42% of the US population is obese right now. Why is it going to be impossible if that hits 60%, or 80%? I ask this as someone with a BMI of 23 who puts a reasonable amount of effort into not becoming obese or overweight again. The personal benefits of not dying from cardiac arrest at 55 are very obvious, but I'm not clear on why healthcare systems won't be able to cope.

Healthcare is already about 20% of the US economy. Where do you think the additional money is going to come from to care for a major increase in diabetics? The rest of the economy doesn't produce enough of a surplus to sustain that.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#168

Post by nradov »

watwut wrote: post #143
nradov wrote: post #52

Earlier quoted context omitted.

Why was this down voted? You're not wrong. Regardless of whether we have a private or socialized healthcare system, we simply won't be able to afford to continue delivering high quality care to everyone with chronic conditions caused by bad dietary choices and sedentary lifestyle. The resources just aren't there so we will increasingly have to ration care.

All in all, we eat and live in a more healthy way then generations before.

No, we really don't. Just look at the way the obesity rate has steadily increased over the past several generations.

https://www.niddk.nih.gov/health-information/health-statisti...

Doctors are now seeing children come in fatty liver disease. That never used to happen.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#169

Post by watwut »

nradov wrote: post #168
watwut wrote: post #143

Earlier quoted context omitted.

All in all, we eat and live in a more healthy way then generations before.

No, we really don't. Just look at the way the obesity rate has steadily increased over the past several generations. https://www.niddk.nih.gov/health-information/health-statisti... Doctors are now seeing children come in fatty liver disease. That never used to happen.

> Doctors are now seeing children come in fatty liver disease. That never used to happen.

They used to die of malnutrition of all kinds. Not just because of being poor, but because of us not knowing this or that is necessary in food.

The physical work people used to do was body breaking fairly often. The chemicals people used to be in daily contact with were body damaging too.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#170

Post by nradov »

macilacilove wrote: post #163
eric4smith wrote: post #154

It’s so interesting that type 2 diabetes is curable with diet. Type 1 is incurable. My point is that the psychology of eating is so strong that people would rather take a drug that pass on birth defects to the future than change eating habits. And I’m a person coming from struggling with just those habits. I think if someone could come up with a treatment to adjust mindsets - it would change healthcare forever and en…

Type 2 diabetes is not curable with diet. Some (but not all) cases of type 2 can be _prevented_ by proper diet (i.e. avoiding obesity). There is no known diet that cures any type of existing diabetes.

Type-2 diabetes can't be cured, but it can be put into permanent remission with diet for many patients. Virta Health has peer-reviewed research supporting this approach.

https://www.virtahealth.com/resource-type/research

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