Live data from Hacker News

Rare genital defects seen in sons of men taking major diabetes drug

science.org

101–110 of 234 posts

Re: Rare genital defects seen in sons of men taking major diabetes drug

#101
post #68

Earlier quoted context omitted.

So the ruling class is forcing you to eat sugar, and you don't have the option to choose for healthier food?

From a big picture, socio-economic point of view, yes, the ruling class (Fortune 500 CEOs and elected officials they donate to and lobby) are essentially forcing the poor, the unaware, the average Joe to eat a diet full of high-fructose corn syrup and other carbohydrates, which happens to be produced by giant agricultural companies. Corn is a subsidized crop by the US Department of Agriculture—we pay farmers to grow…

"are essentially forcing"

Except for the fact that poor immigrants from Bangladesh or Africa do not suffer from the same problem in the first generation, because they are still used to buying staples in the market and cooking traditional meals at home.

The same can actually be seen in UK and Western Europe.

The deadly fact that is compounding the situation is that cooking skills haven't been passed down in a large portion of the Western population for almost two generations now. People who do not know how to cook rely on highly processed stuff that can be heated in 2 minutes in a microwave. Reliance on this highly processed stuff is strongly correlated with bad health outcomes.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#102
post #48

Earlier quoted context omitted.

In responding to your example first - to start with, I live and practice in a country where it isn't a choice between healthcare and food on the table. Beyond that, I believe that it is a basic human right to have free healthcare. The next bit is a bit more complex. I don't think it is right or sensible to advertise medications to people directly. The US is almost alone amongst industrialised/western countries in hav…

> it should (speaking of an idealised utopian world) be easy to get refills of medications that have been appropriately prescribed. I must be living in Utopia then, I thought it was Norway! :-) When I run out of my blood pressure pills I can spend a couple of minutes online to send a message to my doctor. He spends a few seconds online to renew my prescription and then I can go to any pharmacy to pick up three months…

I have a similar set up in the UK - I hit the "request repeat prescription" button in my GP's app, they nod it through and send it to my chosen pharmacy, then a nice person from the pharmacy delivers it the next day. No shady business models required! :D

Re: Rare genital defects seen in sons of men taking major diabetes drug

#103

Earlier quoted context omitted.

From a big picture, socio-economic point of view, yes, the ruling class (Fortune 500 CEOs and elected officials they donate to and lobby) are essentially forcing the poor, the unaware, the average Joe to eat a diet full of high-fructose corn syrup and other carbohydrates, which happens to be produced by giant agricultural companies. Corn is a subsidized crop by the US Department of Agriculture—we pay farmers to grow…

"are essentially forcing" Except for the fact that poor immigrants from Bangladesh or Africa do not suffer from the same problem in the first generation, because they are still used to buying staples in the market and cooking traditional meals at home . The same can actually be seen in UK and Western Europe. The deadly fact that is compounding the situation is that cooking skills haven't been passed down in a large p…

Agree

Re: Rare genital defects seen in sons of men taking major diabetes drug

#104
post #27

Earlier quoted context omitted.

It is also beginning to be prescribed by many of the subscription medication/doctor businesses that are springing up, powered by VC cash and looking to build strong forward flowing subscription businesses. Their model is: - find areas that aren’t medically serious (speaking relatively, and in relation to life threatening - erectile dysfunction and male pattern baldness) - run people through online questionnaires - ge…

Do you see this as a bad thing? As someone who doesn't have any insurance, I'm extremely grateful for these. I don't want to have to go through the current medical racket where unless you pay a doc $300 you won't be allowed to purchase the medication you want. And then of course there's the follow up appointments, a "med check" where they can bill you $150 every 90 to 180 days just to hear you say, "yep, things are f…

Good or bad, it's the logical conclusion given the free market, healthcare, and the Internet. The real problem is the "as someone without insurance" bit, the bigger question is what is best for society?

Re: Rare genital defects seen in sons of men taking major diabetes drug

#105

Earlier quoted context omitted.

From a big picture, socio-economic point of view, yes, the ruling class (Fortune 500 CEOs and elected officials they donate to and lobby) are essentially forcing the poor, the unaware, the average Joe to eat a diet full of high-fructose corn syrup and other carbohydrates, which happens to be produced by giant agricultural companies. Corn is a subsidized crop by the US Department of Agriculture—we pay farmers to grow…

"are essentially forcing" Except for the fact that poor immigrants from Bangladesh or Africa do not suffer from the same problem in the first generation, because they are still used to buying staples in the market and cooking traditional meals at home . The same can actually be seen in UK and Western Europe. The deadly fact that is compounding the situation is that cooking skills haven't been passed down in a large p…

> The deadly fact that is compounding the situation is that cooking skills haven't been passed down in a large portion of the Western population for almost two generations now. People who do not know how to cook rely on highly processed stuff that can be heated in 2 minutes in a microwave. Reliance on this highly processed stuff is strongly correlated with bad health outcomes.

People either feel that they don't have time to prepare and cook or they see it as inefficient since it is much faster and cheaper to dine-out or takeaway.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#106
post #99
post #78

Obese women’s offspring have double the risk of hypospadius, and women having babies after 40 have 4x the risk of hypospadius. Metformin is a drug that men are probably 100x more likely to be on at 45 vs 25. Therefore men on metformin are far more likely to be reproducing with older (and likely obese) women. I’m not saying this explains all the correlation, I’m just saying if the study doesn’t really make a good effo…

They obviously control for age, at minimum.

"obviously" is an assumption; it's better to read the paper to confirm this, of course.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#107

It’s sad seeing the crazy downstream multigenerational damage that massive sugar consumption is causing as obesity rates reach 50%. Good luck future humanity.

From what I recall reading about epigenetics, diabetes is caused by a too fast change in diet towards high calorie. After several generations the metabolism thriftiness goes down if the diet level remain the same, and thus diabetes rates will go down. Same concept happens in reverse when there is periods of famine.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#108
post #38

Earlier quoted context omitted.

It’s an extremely sad situation and will guarantee every single healthcare system eventually breaks down.

You're saying that it's a guarantee that every single healthcare system (in the world?) will break down because of _sugar consumption_? Seriously?

If sugar consumption is the leading factor in obesity, and if obesity is the leading factor in added pressure to the health care system, then... it's definitely a big preventable factor, I'd say.

But it's not absolutes. Anyway yeah, some lifestyle choices need to be addressed to reduce pressure on the health care system. Like how for two years now we've had certain measures in place like social distancing and facial masks, not to eradicate the virus (that would require extended full stay-at-home mandate lockdowns) but to keep pressure on the health care system manageable.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#109
post #62

It’s sad seeing the crazy downstream multigenerational damage that massive sugar consumption is causing as obesity rates reach 50%. Good luck future humanity.

I believe this is intentional. If the ruling class wanted workers to live long, they'd force them to switch to oatmeals, fruits and water, while sugar would be a substance competing in price with cocaine.

There is no one ruling class though; one part wants workers, the other wants to sell stuff. They're competing with each other. Muh free market.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#110
post #94

Earlier quoted context omitted.

I lost 20 pounds, got off antidepressants and found love all within 6 months of leaving America at age 24. I don’t really have a point, but there is a lot of poison for body and mind in that country.

Out of curiosity, where did you move to?

Cambodia
Post reply on HN