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Rare genital defects seen in sons of men taking major diabetes drug

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Re: Rare genital defects seen in sons of men taking major diabetes drug

#91

Post by roystonvassey »

adewinter wrote: post #60
ecf wrote: post #38

Earlier quoted context omitted.

It’s an extremely sad situation and will guarantee every single healthcare system eventually breaks down.

You're saying that it's a guarantee that every single healthcare system (in the world?) will break down because of _sugar consumption_? Seriously?

Yeah if birth rates stay low ( which they have now for a few decades esp in Western countries but true elsewhere), you’ll need either large scale immigration or lots of cash to service the social care system, which now has to service the growing number of the geriatric and chronically il

Re: Rare genital defects seen in sons of men taking major diabetes drug

#92

Post by DeWilde »

Metformin is also pretty bad when comes to impact to testosterone levels, at least in most men. The exact mechanism that this happens is that it saps the cholesterol from your blood. This cholesterol would otherwise be used for T production by the testes.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#93

Post by Gatsky »

TylerE wrote: post #58
Gatsky wrote: post #11

> In the United States, prescriptions to 18- to 49-year-olds with type 2 diabetes grew from fewer than 2200 in 2000 to 768,000 in 2015. What the hell… that has to be a mistake? What is going on? Can poor lifestyle really cause this massive increase in young people with diabetes??

Despite being used in Europe since the '50s, Metformin wasn't introduced in the US until 1995.

Ah right, that is surprisingly late, and would likely explain the numbers.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#94

Post by Nitrolo »

idontwantthis wrote: post #90
dayvid wrote: post #81

Earlier quoted context omitted.

I agree. After living and traveling abroad, it's easy to see America has an obese-default culture. Most cities and towns have little walking or public transportation. Cheap, high-calorie, nutrient-poor food is easily available anywhere 24 hours a day. Restaurants have an abundance of large amounts of meat and carbohydrates drenched in low-quality oils and sugary seasonings. You have to be consciously active to stay f…

I lost 20 pounds, got off antidepressants and found love all within 6 months of leaving America at age 24. I don’t really have a point, but there is a lot of poison for body and mind in that country.

Out of curiosity, where did you move to?

Re: Rare genital defects seen in sons of men taking major diabetes drug

#95

Post by lippel82 »

based69 wrote: post #78

Obese women’s offspring have double the risk of hypospadius, and women having babies after 40 have 4x the risk of hypospadius. Metformin is a drug that men are probably 100x more likely to be on at 45 vs 25. Therefore men on metformin are far more likely to be reproducing with older (and likely obese) women. I’m not saying this explains all the correlation, I’m just saying if the study doesn’t really make a good effo…

From the artcile: "The numbers were small — 13 metformin-exposed boys were born with genital defects. But after the researchers adjusted for factors including parental ages and maternal smoking status, they found a 3.39-fold rise in the odds of a genital defect. “The rate per se was surprisingly high,” Wensink says."

Re: Rare genital defects seen in sons of men taking major diabetes drug

#96

Post by sph »

ceeplusplus wrote: post #29
giantg2 wrote: post #12

Earlier quoted context omitted.

Wow, if they aren't suggesting dietary and exercise based solutions first, that's a huge red flag. Find a new doctor.

Prescriptions of diet and exercise are ineffective because many obese / type 2 diabetic people can't exercise self-control. That's why they're obese in the first place. It's way easier to take a pill than cut to 1500 calories a day for 2 years.

Bullshit, and my response is a bit tangential, sorry. Obesity isn't a defect of self-control, it's a systematic metabolic disease that makes these people ravenous yet ingest enormous amount of calories.

Low carb eating has been successful outside of the mainstream lie of "eat more whole grains" because it simply avoids the foods that worsen runaway metabolic syndrome; the common advice is just to "eat less", while these poor people are ravenous and gain fat on whole foods 2,000 kcal diets. CICO doesn't mean anything in a vacuum if one way of eating causes you to be constantly hungry, and the other teaches your body to make use of its great amount of stored energy.

Obesity is eating the same food that previously kept you healthy, but now makes you sick and hungry.

Here's abundance of doctors and researchers talking about it: https://www.youtube.com/c/lowcarbdownunder/search?query=diab...

Here's one I've watched and can recommend: Prof. Robert Lustig - 'Sugar, metabolic syndrome, and cancer': https://www.youtube.com/watch?v=jpNU72dny2s

Re: Rare genital defects seen in sons of men taking major diabetes drug

#97

Post by donkeydoug »

sp332 wrote: post #64
adewinter wrote: post #60

Earlier quoted context omitted.

You're saying that it's a guarantee that every single healthcare system (in the world?) will break down because of _sugar consumption_? Seriously?

Diabetes is really rough on the organs. Especially once the kidneys go, you need dialysis 3 times per week and the treatment takes hours. If a substantial fraction of the population needs that treatment, it's going to be rough. Plus the eye surgeries for glaucoma, and other kinds of organ failure.

can't decide if it's good or bad then that we somehow have universal care... but only for kidneys, lol https://www.npr.org/transcripts/131167638

Re: Rare genital defects seen in sons of men taking major diabetes drug

#98

Post by kwhitefoot »

robbiep wrote: post #48
freedomben wrote: post #34

Earlier quoted context omitted.

Do you see this as a bad thing? As someone who doesn't have any insurance, I'm extremely grateful for these. I don't want to have to go through the current medical racket where unless you pay a doc $300 you won't be allowed to purchase the medication you want. And then of course there's the follow up appointments, a "med check" where they can bill you $150 every 90 to 180 days just to hear you say, "yep, things are f…

In responding to your example first - to start with, I live and practice in a country where it isn't a choice between healthcare and food on the table. Beyond that, I believe that it is a basic human right to have free healthcare. The next bit is a bit more complex. I don't think it is right or sensible to advertise medications to people directly. The US is almost alone amongst industrialised/western countries in hav…

> it should (speaking of an idealised utopian world) be easy to get refills of medications that have been appropriately prescribed.

I must be living in Utopia then, I thought it was Norway! :-)

When I run out of my blood pressure pills I can spend a couple of minutes online to send a message to my doctor. He spends a few seconds online to renew my prescription and then I can go to any pharmacy to pick up three months of pills. For the rest of the year I just go to a pharmacy to pick up a repeat when I run out.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#99

Post by ralusek »

based69 wrote: post #78

Obese women’s offspring have double the risk of hypospadius, and women having babies after 40 have 4x the risk of hypospadius. Metformin is a drug that men are probably 100x more likely to be on at 45 vs 25. Therefore men on metformin are far more likely to be reproducing with older (and likely obese) women. I’m not saying this explains all the correlation, I’m just saying if the study doesn’t really make a good effo…

They obviously control for age, at minimum.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#100

Post by dmix »

based69 wrote: post #78

Obese women’s offspring have double the risk of hypospadius, and women having babies after 40 have 4x the risk of hypospadius. Metformin is a drug that men are probably 100x more likely to be on at 45 vs 25. Therefore men on metformin are far more likely to be reproducing with older (and likely obese) women. I’m not saying this explains all the correlation, I’m just saying if the study doesn’t really make a good effo…

The 90 day window for taking the drug and seeing an impact is in the studies favour though.

> the researchers saw no effect in offspring of men who took the drug earlier in life or in the year before or after the 90-day window of sperm production. “It really has to do with taking it in that window when the sperm … is being developed,” says senior author Michael Eisenberg, a urologist at Stanford Medicine.

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