Live data from Hacker News

Rare genital defects seen in sons of men taking major diabetes drug

science.org

11–20 of 234 posts

Re: Rare genital defects seen in sons of men taking major diabetes drug

#11
> In the United States, prescriptions to 18- to 49-year-olds with type 2 diabetes grew from fewer than 2200 in 2000 to 768,000 in 2015.

What the hell… that has to be a mistake? What is going on? Can poor lifestyle really cause this massive increase in young people with diabetes??

Re: Rare genital defects seen in sons of men taking major diabetes drug

#12
post #2

Metformin is the first resort in diabetes treatment. If it proves to truly increase birth defects by 40% that may have to change. It was my doctor's first resort for me, but the side effects were too severe and I stopped it. He vaguely mentioned that it would help if I lost weight, but made no mention of what actually resolved my diabetes, a low carb diet. I hope that becomes the first resort. Apparently around here…

Wow, if they aren't suggesting dietary and exercise based solutions first, that's a huge red flag. Find a new doctor.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#13
post #11

> In the United States, prescriptions to 18- to 49-year-olds with type 2 diabetes grew from fewer than 2200 in 2000 to 768,000 in 2015. What the hell… that has to be a mistake? What is going on? Can poor lifestyle really cause this massive increase in young people with diabetes??

It's an increase in a particular treatment for a disease, which is only a contingent proxy for the disease itself. A change on that scale could plausibly be explained by a change in the standard approach to treatment or diagnostic criteria. Wouldn't be surprised if insurance played a role somehow.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#14
post #11

> In the United States, prescriptions to 18- to 49-year-olds with type 2 diabetes grew from fewer than 2200 in 2000 to 768,000 in 2015. What the hell… that has to be a mistake? What is going on? Can poor lifestyle really cause this massive increase in young people with diabetes??

that doesn't say that diagnoses increased that much, just that this particular drug has become a much more popular way to treat it.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#15
Metformin is also sometimes used to induce ovulation in non-obese women of childbearing age with polycystic ovarian syndrome.[0] Luckily, this study seems to only show an effect if taken within the 90 day window before conception, so it seems to be doing something to the sperm, and not causing genetic changes. Also, of course, we'd want to see corroborating studies.

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200666/

Re: Rare genital defects seen in sons of men taking major diabetes drug

#16
post #12
post #2

Metformin is the first resort in diabetes treatment. If it proves to truly increase birth defects by 40% that may have to change. It was my doctor's first resort for me, but the side effects were too severe and I stopped it. He vaguely mentioned that it would help if I lost weight, but made no mention of what actually resolved my diabetes, a low carb diet. I hope that becomes the first resort. Apparently around here…

Wow, if they aren't suggesting dietary and exercise based solutions first, that's a huge red flag. Find a new doctor.

Assumption makes an ass, but I think he means first line treatment when it comes to medicine. I’m sure that both nurse & doctor wholly recommended lifestyle changes.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#17
post #4
post #2

Metformin is the first resort in diabetes treatment. If it proves to truly increase birth defects by 40% that may have to change. It was my doctor's first resort for me, but the side effects were too severe and I stopped it. He vaguely mentioned that it would help if I lost weight, but made no mention of what actually resolved my diabetes, a low carb diet. I hope that becomes the first resort. Apparently around here…

Unfortunately the vast vast majority of people won't commit to a big lifestyle change like that in the first place, and a big majority of the people that due end up not following through. So most doctors won't bother suggesting it as a legitimate option because for most people it kind of isn't.

"So most doctors won't bother suggesting it as a legitimate option because for most people it kind of isn't."

This is just flat wrong and borders on malpractice for deceptive counseling. Even if a patient is unlikely to accept an option, they still need to be presented with the best/standard options. This is also the lowest risk and highest gain option with a proven track record. I would stop seeing a doctor who is not presenting all the standard options and would rather just have me pop pills.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#18
post #8
post #4

Earlier quoted context omitted.

Unfortunately the vast vast majority of people won't commit to a big lifestyle change like that in the first place, and a big majority of the people that due end up not following through. So most doctors won't bother suggesting it as a legitimate option because for most people it kind of isn't.

At some point in every doctor's career, there is a point where they decide to let us eat cake.

Doctors aren't supposed to decide much of anything for us, especially lifestyle choices. But they should at least present the appropriate options once.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#19
post #12
post #2

Metformin is the first resort in diabetes treatment. If it proves to truly increase birth defects by 40% that may have to change. It was my doctor's first resort for me, but the side effects were too severe and I stopped it. He vaguely mentioned that it would help if I lost weight, but made no mention of what actually resolved my diabetes, a low carb diet. I hope that becomes the first resort. Apparently around here…

Wow, if they aren't suggesting dietary and exercise based solutions first, that's a huge red flag. Find a new doctor.

One of my scariest adulthood realizations is that doctors are like everybody else; fallible. And that being certified means you're good at studying, but doesn't always mean you're good at what you've studied.

Not trying to discredit medical professionals or the amount of work they put in. I'm sure the majority are intelligent, conscientious and good at their jobs.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#20
post #16
post #12

Earlier quoted context omitted.

Wow, if they aren't suggesting dietary and exercise based solutions first, that's a huge red flag. Find a new doctor.

Assumption makes an ass, but I think he means first line treatment when it comes to medicine. I’m sure that both nurse & doctor wholly recommended lifestyle changes.

If you read the comment they said there was mention of losing weight but nothing about a low carb diet. Carbs are something any diabetic person should be counseled on, even if being placed on a medication.
Post reply on HN