Doctor prescribed anti-inflammatory for a pinched nerve I have...cured mine.
Ketamine for the acute treatment of severe suicidal ideation
51–60 of 120 posts
Re: Ketamine for the acute treatment of severe suicidal ideation
#52Earlier quoted context omitted.
I’m sorry but you are strongly over exaggerating the (side) effects of i.v. ketamine. It’s not a dose that sends you in a K hole. It’s way less than that. Some get sedation and some do get dissociative symptoms which can unmask the study arm of the patient. Approximately one out of ten got at least one of those side effects. Sedation can be mimicked with midazolam, so if you use that as placebo, you get 90 % of the p…
Umm…ketamine IV at these doses is most certainly a unique and insane experience, speaking as someone who’s done it about a dozen times for anxiety.
How often do you need maintenance?
How numb does it make you. My mouth and throat being numb was very surprising.
Re: Ketamine for the acute treatment of severe suicidal ideation
#53Earlier quoted context omitted.
Have you had it? A friend of mine did it last week and he described it as the most intense experience of his life. He’s 40 and he has experience with other drugs. I think possibly you don’t know what you’re talking about?
Right it varies greatly depending on dose. If you don't know the exact dose your friend took (they don't sound like an anesthesiologist) then you're insulting someone you likely know much less than.
Clinics in the US seem to all use .5 mg/kg as a baseline
Re: Ketamine for the acute treatment of severe suicidal ideation
#54Earlier quoted context omitted.
>1.The nurse administering knew if it was placebo or active (for safety reasons). I read it as the nurse preparing the IV's knew if it was a placebo, it doesn't really say that the same nurse administered the IV's.
The nurse administering it is most certainly liable for what s/he administers. It is a very big no-no to blindly administer a medication of which you cannot reasonably verify what it is. To push a syringe or start a pump of something that "could be ketamine, or could be NS" is walking an uncomfortable line for your license to practice nursing. Right patient, right medication, right dose, right route, right time. If y…
>Right patient, right medication, right dose, right route, right time
Can't you achieve all of those by having someone else create the bag and then label it for the patient. The "right medication" is the one they're receiving as part of the study.
It's not like what they need to do is different if it's ketamine or saline.
Re: Ketamine for the acute treatment of severe suicidal ideation
#55Earlier quoted context omitted.
Have you had it? A friend of mine did it last week and he described it as the most intense experience of his life. He’s 40 and he has experience with other drugs. I think possibly you don’t know what you’re talking about?
I think possibly commercial “infusion clinics” and medical trials use different doses.
IM and IV are going to be very similar. Smaller independent psychologist will do IM while bigger clinics with nursing staff will typically use IV.
At home treatments with sublingual trockies have much less side affects, but differently still noticeable. Nasal spray is the weakest with just some minor body numbing.
Re: Ketamine for the acute treatment of severe suicidal ideation
#56Earlier quoted context omitted.
I don't think I am exaggerating the noticeable effects of i.v. ketamine. Patients given i.v. ketamine are advised not to operating an automobile hours after administration. This level of impairment would be noticeable to the patient and the staff administering the treatment.
Advice not to operate an automobile is for minimizing risks. It doesn't mean that most would be unable to handle a car, although it could mean that their reaction times would be slower. The standard way to administer ketamine is to give 0,5 mg/kg under 40 minutes. It would in no way be immediately obvious to everyone in, if someone began to receive ketamine or not. At least I couldn't differentiate them at that point…
Maybe you have more experience with patients at this specific dose range than I do. I remain skeptical this could be double blind, but do have less certainty than I originally started with.
Re: Ketamine for the acute treatment of severe suicidal ideation
#57> Then, patients received a first 40 minute intravenous infusion of ketamine (0.5 mg/kg) or placebo 0.9% (saline solution) in addition to their current treatment. This really shouldn’t be labeled as double blind. 1.The nurse administering knew if it was placebo or active (for safety reasons). 2. It would immediately become obvious to the subject if they were injected with salt water or ketamine. 3. Within minutes it…
0.5mg/kg spread out over 40 minutes wouldn’t be as dramatic as you’re suggesting.
> 3. Within minutes it would become obvious to everyone in the room if the patient was injected with salt water or ketamine.
I think you’re mistaking IV infusion for injection. The dose is given slowly over 40 minutes, not as a rapid injection. The patient would barely have any of the drug in their system in the first few minutes. Given the short duration of action, it wouldn’t produce peak levels anywhere near what recreational users experience.
Re: Ketamine for the acute treatment of severe suicidal ideation
#58> Then, patients received a first 40 minute intravenous infusion of ketamine (0.5 mg/kg) or placebo 0.9% (saline solution) in addition to their current treatment. This really shouldn’t be labeled as double blind. 1.The nurse administering knew if it was placebo or active (for safety reasons). 2. It would immediately become obvious to the subject if they were injected with salt water or ketamine. 3. Within minutes it…
My psychiatrist administers IV ketamine treatments for depression. (I don't use those; regular antidepressants work for me.) I'm not sure what dosage she uses, but from what she's told me, it's not a drug trip, and a lot of people don't feel any different during the treatment. [Edited to clarify.]
Does is dependent on weight (and gender?) if I remember correctly.
Re: Ketamine for the acute treatment of severe suicidal ideation
#59I did a full 6 week course of ketamine therapy. It was really good, and I would recommend it if you're open minded. It's not for everyone, and the lasting (a year+) benefits aren't really measurable (maybe I'm different? maybe I'm not, maybe I've just gotten older). I'd like to go again and see if it can help with my obsessive existential dread.
what about how it felt early on / during the therapy ? what about side effects also ?
There is the "trip" side affect which lasts about 30-45 minutes. Then there is some wobbly legs and slow speech for an hour or two after. I had no side-affects besides those.
Re: Ketamine for the acute treatment of severe suicidal ideation
#60Earlier quoted context omitted.
Have you had it? A friend of mine did it last week and he described it as the most intense experience of his life. He’s 40 and he has experience with other drugs. I think possibly you don’t know what you’re talking about?
I think possibly commercial “infusion clinics” and medical trials use different doses.
Going by a friends experience, infusion clinics need to be investigated more regularly by medical professionals. Co-worker went to one for treatment and from her recollection of the event they left her in a dark room with a white noise generator while she went down the k-hole. Terrified the living shit out of her.