I'm not a pro user but PipeWire has been mostly great. I originally switched because of PulseAudio was causing a hissing noise on with my bluetooth headset, and switching fixed it. However, there are still two issues that I'm struggling with and haven't been able to find a definitive answer for. One is the audio sometimes randomly jitters while simply playing music. It seems this only happens when I use my bluetooth…
I encounter the same issue from time to time. Almost consistently reproducible when I update the kernel and the VirtualBox driver needs to be recompiled (and there's no cap for that process that it should use max X% of CPU).
As pipewire is within the user session I would assume higher system load would induce some latency and cause the jitterness.
But in the end I'm just making assumptions, and correlating.