I recently made the switch in NixOS and found it pretty painless. Can't get my mic to work in Firefox though, and the other day I was looking through the manual trying to figure out how to use my HDMI screen's speakers rather than the built-in one and couldn't find the right incantation. Sounds like such rough corner cases will be a thing of the past soon. Congrats to the dev team!
I wonder how your setup is different than mine. I also switched to Pipewire (some months ago) and I'm using NixOS and Arch Linux, and on both I could just change the audio output to my speakers on my monitors (via HDMI) with the usual device switch, same as before with just PulseAudio. Everything works perfectly.
This is my pipewire config, does the job perfectly for me, tracking unstable.