Leave your house. Remote work has downsides, but you have the ability to fix them as opposed to the office where your only option is to switch jobs.
Do you mean "leave your house... to work somewhere else"? If so, that's sort of an option. But at that point, I might as well be working with my coworkers. If you mean "leave your house... outside work hours", this is also becoming more and more possible, yet most of my waking hours are part of my workday.
Leave your house to exercise, to do some task, to just see people going around. Do not stay all your time outside of work alone, go somewhere where there are people, and meet them. It doesn't need to be every day, but often enough.