Then there is this:
https://www.npr.org/sections/health-shots/2022/02/06/1074719...
Zap your head or a fecal transplant? Choices, choices.
Gut microbe linked to depression in large health study
41–50 of 297 posts
Re: Gut microbe linked to depression in large health study
#42Will be interested to at some point see what kind of connection gastrointestinal autoimmune (among others) diseases such as Crohn’s and Ulcerative Colitis have on not only the guy microbe balance, but mental health as well. Many mental health disorders have strong genetic ties, as well as autoimmune diseases. Wonder if existence of one makes the likelihood of existence of the other greater.
There's some progress now in tying specific mental disorders to autoimmune problems in the brain. Wish I could tell you more but all I know about this is that they test people's cerebral spinal fluid for antibodies against specific neurotransmitter receptors, and they've discovered several connections between those and problems people have.
Re: Gut microbe linked to depression in large health study
#43Tangential: Is there any evidence that pro biotic foods or supplements can increase gut health? Given the evident importance of gut health, I wonder whether it's worth using something like this, to grab a random example: https://www.amazon.co.uk/Restored-Bio-Cultures/dp/B082SZXBF2...
Eat fiber. Meet the recommended amount and eat a diverse set of fiber which will feed different microbes in the gut. It will take some time for the gut to adjust to the new levels though. Expect gas, cramping, etc for a few days.
Re: Gut microbe linked to depression in large health study
#44Earlier quoted context omitted.
Or Kimchi if you're into Korean food.
Do you have an easy to make recipe?
Most lactofermented foods are: Main ingredient, spices, a few tbsp of salt. Add to sterile jar, fill with water (add a glass weight to the top if needed to keep everything submerged) and leave in a dark cabinet for a few weeks. Trial and error to get the flavor the way you want it, but that's basically it. If you see little air bubbles forming near the bottom after 2-4 days, you have a live culture.
Re: Gut microbe linked to depression in large health study
#45Tangential: Is there any evidence that pro biotic foods or supplements can increase gut health? Given the evident importance of gut health, I wonder whether it's worth using something like this, to grab a random example: https://www.amazon.co.uk/Restored-Bio-Cultures/dp/B082SZXBF2...
Sauerkraut is simple to make and cabbage is cheap. https://www.livestrong.com/article/413921-does-sauerkraut-ha...
Personally kefir, sauerkraut, kimchi, kombucha - all give me lots of bloating even after trying out for weeks. Maybe thats just how its supposed to be? Not sure but I stopped after a while after it affected my daily life
Re: Gut microbe linked to depression in large health study
#46Gut microbiome researcher here - not involved in this study but happy to answer questions or dig in with anyone interested!
Weird question perhaps, some research suggests that bacteria source nutrients from the cell lining in the gut if there is an absence of sufficient nutrients from the food coming into the digestive system. (example: https://www.cell.com/cell/fulltext/S0092-8674(16)31464-7)
That made me wonder what the triggers might be, since the studies see the corroding effect appear in diets deficient in polyphenols/insoluble fibres. At what interval do microbes need nutrients and is simply eating a highly-processed snack that has nothing much to offer bacteria in the gut a possible trigger in itself?
Re: Gut microbe linked to depression in large health study
#47Gut microbiome researcher here - not involved in this study but happy to answer questions or dig in with anyone interested!
In your opinion, what is the best study that shows direct evidence that changes in gut flora can change health outcomes (preferably something that is a randomized control study). The only area I feel comfortable that good data exists is in the setting of fecal transplants for refractory clostridioides difficile infection. Thanks.
Re: Gut microbe linked to depression in large health study
#48Great to see the gut brain axis becoming more well known in medicine. Less than 10 years ago it was considered near pseudoscience to consider that the gut could actually influence the brain.
https://www.hopkinsmedicine.org/health/wellness-and-preventi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367209/#:~:tex....
Re: Gut microbe linked to depression in large health study
#49Tangential: Is there any evidence that pro biotic foods or supplements can increase gut health? Given the evident importance of gut health, I wonder whether it's worth using something like this, to grab a random example: https://www.amazon.co.uk/Restored-Bio-Cultures/dp/B082SZXBF2...
As a fellow comment says - its all over the place and kind of hard to say, see [1] saying they are useless but lots of studies saying they are useful . Personally as someone with IBS, I have tried many probiotics over the years and have mixed results - most of them were useless but for some time I found one or 2 that worked but I couldnt say for sure if they worked due to other factors (for e.g generally healthier fo…
Not sure if you have heard of the low FODMAP diet? Its now the standard treatment for IBS. The theory is certain bacteria ferment FODMAPS into gas and water which leads to the symptoms. They don't know which bacteria yet but going low fodmap is now a well researched and accepted treatment.
Everyone is different but personally, I'm able to tolerate everything except Fructans (one of several types of FODMAPS). So no garlic, onion or wheat for me.
https://www.monashfodmap.com/ibs-central/i-have-ibs/starting...
Re: Gut microbe linked to depression in large health study
#50Will be interested to at some point see what kind of connection gastrointestinal autoimmune (among others) diseases such as Crohn’s and Ulcerative Colitis have on not only the guy microbe balance, but mental health as well. Many mental health disorders have strong genetic ties, as well as autoimmune diseases. Wonder if existence of one makes the likelihood of existence of the other greater.
There's some progress now in tying specific mental disorders to autoimmune problems in the brain. Wish I could tell you more but all I know about this is that they test people's cerebral spinal fluid for antibodies against specific neurotransmitter receptors, and they've discovered several connections between those and problems people have.
Very interesting! I actually have both Crohn’s and bipolar disorder, and one anecdote that’s interesting (to me) is that the TNF inhibitor I’m on, which has put Crohn’s in remission, has simultaneously appeared to have a positive effect on the mood disorder side of things as well.
Really cool to see the GI getting so much research!
Edit: Found an interesting study that addresses the relationship between TNF and mood disorders - go figure!