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Gut microbe linked to depression in large health study

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Re: Gut microbe linked to depression in large health study

#31

Tangential: Is there any evidence that pro biotic foods or supplements can increase gut health? Given the evident importance of gut health, I wonder whether it's worth using something like this, to grab a random example: https://www.amazon.co.uk/Restored-Bio-Cultures/dp/B082SZXBF2...

Another anecdata point:

I used be lethargic, couldn't get myself to do anything but be on the sofa. I would get horrible migraine headaches if drinking alcohol or even alcohol free beer or eat certain foods. I self-diagnosed histamine intolerance through trial and error.

I tried multiple pro-biotic combinations. An easy one I tried in the beginning was simply some Danone Actimel the family had in the fridge anyway. I can attest to the fact that it contains live bacteria (a strain that makes lots of histamines) that do make it to the gut because it gave me the horrible migraine headache as would Sauerkraut actually. Researched what strains don't create lots of histamine. I landed on Garden of Life - Primal Defense Ultra. What I think made the difference is that it contains Bacillus subtilis. I say that because I tried two or three others that had largely the same makeup of strains but none had that particular bacterium. It's a soil based bacterium which you might get from eating your own cabbage you grew in the garden as well. Almost everything else just has various different strains of lactobacilli.

Taking 3 capsules a day I felt like crap for 2 weeks (no headaches, just feeling sick, like a bad cold) and then things got better. I am able to drink alcohol again (I'll get a hangover headache like anyone would if I drink too much but it's not longer a day long migraine from just sipping 10ml) and eat anything I want to in any quantity. I still take one in the morning and one in the evening and I put one into the Sauerkraut I make.

YMMV as always, not a doctor, try at your own risk, not affiliated etc :)

Re: Gut microbe linked to depression in large health study

#32

or depression causes this bacteria to proliferate more easily? I see nothing in that research showing causation. It doesn't invalidate their correlation though.

Do they claim causation anywhere? All I see is them saying there appears to be a link.

Re: Gut microbe linked to depression in large health study

#33

Tangential: Is there any evidence that pro biotic foods or supplements can increase gut health? Given the evident importance of gut health, I wonder whether it's worth using something like this, to grab a random example: https://www.amazon.co.uk/Restored-Bio-Cultures/dp/B082SZXBF2...

https://pendulumlife.com/pages/science

From the maker but I heard about it on a podcast and was convinced.

Re: Gut microbe linked to depression in large health study

#34
If you’re like me and somehow missed out that there’s an significant mesh of neurons in your guts that’s capable of independent neurotransmitter release, you should look up the enteric nervous system.

Intuitively, at least, it seems to make sense of all the ‘gut’ connections to mood.

Re: Gut microbe linked to depression in large health study

#35

Earlier quoted context omitted.

Or Kimchi if you're into Korean food.

Do you have an easy to make recipe?

Not GP and don't have one to suggest, but as you're asking for 'easy' (and at risk of stating the obvious, but only once you know I suppose) - ignore anything that says something like 'refigerate for 30mins and enjoy'.

Or don't, I'm not denying quick such er salads can taste great, just that if what you want is a fermented or pickled product, that takes time. (And much longer if at all in the fridge - that's their purpose!)

A 'proper' recipe for sauerkraut for example will tell you something on the order of weeks at minimum, and it's done when you like the taste. Kimchi I think is typically fermented for longer, more like months or over a year (not including any transferred to the next batch).

Re: Gut microbe linked to depression in large health study

#36
post #29

Gut microbiome researcher here - not involved in this study but happy to answer questions or dig in with anyone interested!

People are sharing anecdata around improving their biome by eating sauerkrauts and nobody asked you any question yet... this is sad.

Re: Gut microbe linked to depression in large health study

#38
post #29

Gut microbiome researcher here - not involved in this study but happy to answer questions or dig in with anyone interested!

Hi!

Thanks a ton - super curious research. What determines if individuals get Morganella and Kiebdiella bacteria? Is it genetic or can it be impacted by the food we eat?

What is the mechanism of how these bacterias interact with the brain through the enteric system?

Thank you!

Re: Gut microbe linked to depression in large health study

#39
post #29

Gut microbiome researcher here - not involved in this study but happy to answer questions or dig in with anyone interested!

At the current pace of research and studies, when do you think we could expect to see something come to 'market' that could be used - first as a diagnosis and then as a treatment/medication/technique.

As someone with IBS - right now I feel like there is no clear 'problem' defined for it. You are just categorized by the doctor (Rome 3 or whatever) and people go through various tests, medications, non-fda approved stuff to see what works.

I am eagerly looking forward to some progress in this area to hopefully fully understand whats going on and get a proper diagnosis

Re: Gut microbe linked to depression in large health study

#40
post #29

Gut microbiome researcher here - not involved in this study but happy to answer questions or dig in with anyone interested!

Is there a good way to test one's own gut microbiome? To determine how healthy it is or isn't, and to track how it changes over time. Basically I want to be able to tell how my diet and things like antibiotics affect it.
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