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Moderna’s HIV vaccine has officially begun human trials

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Re: Moderna’s HIV vaccine has officially begun human trials

#401

Post by mlyle »

Retric wrote: post #391
mlyle wrote: post #387

Earlier quoted context omitted.

> I don’t think most peoples 25 year old self can really identify what their 85 year old self will be like. Yes, and I believe this is a reason why people make choices that adversely affect their 50 year old self. Who's that guy in the future going to be? Why should I care about making it better for him?

You could say the same thing about people drinking heavily only to wake up the next day with a massive hangover. So it isn’t the differences between them that’s causing people to screw over their future self.

I can't comprehend 1000-year-from-now me. I don't think I would take many actions to improve life for 1000-year-from-now me even if I knew I could live millennia. Doing so does not buy me any comfort today and does not let me "give" to any person that I identify with or recognize as part of me.

I can imagine time scales on a par with how long I've lived and to a lesser extent to the ages of people I identify with.

(500 year from now me would see the first paragraph as exceptionally foolish... and also inevitable. But that fact doesn't change the truth of what I'm saying).

Re: Moderna’s HIV vaccine has officially begun human trials

#402

Post by dillondoyle »

chucksmash wrote: post #186
hdjjhhvvhga wrote: post #167

Earlier quoted context omitted.

I didn't know this. Could you explain the reason?

Presumably the viral load required for transmission is greater than the viral load required for detection.

I mean just based on the definition that seems like the literal meaning to me. But i'm not a PHD

Re: Moderna’s HIV vaccine has officially begun human trials

#403

Post by mlyle »

hashimotonomora wrote: post #359
et2o wrote: post #334

Earlier quoted context omitted.

There is no data that supports this assertion whatsoever. There is a lot of evidence going against it. Theoretically it may be possible, but the probability of this is on the order of 0 and so close to 0 it will likely never happen. Think of it like chemistry. Sure, two covalently bonded hydrogen atoms at STP could have nuclei 1cm from each other due to random chance. However, the probability of this happening is so…

The assertion is still false then.

It's effectively true.

If one bounds the risk from HIV from an undetectable partner to an unmeasurably small epsilon, dwarfed by other risks by many orders of magnitude--- the edges where the assertion are false don't matter.

Re: Moderna’s HIV vaccine has officially begun human trials

#404

Post by dillondoyle »

Terry_Roll wrote: post #338
Nbox9 wrote: post #198

Earlier quoted context omitted.

CDC backing up this claim. Having an undetectable viral load prevents transmission during sex —- but likely not during needle sharing. The answer to why seems to be an obvious “because there are less virus particles”. I’m linking a couple of scientific studies following couples having condomless sex where one partner is HIV positive, on ART with low viral load. Among the about 2000 couples in these studies there were…

So some other points. Some Sex lubes can make it easier for infections to get into the body. https://en.wikipedia.org/wiki/Personal_lubricant#Water-based Thing is I wonder if a higher vitamin A and zinc intake can help because all epithelial cells need retinol (vitamin A), zinc is needed to move retinol around the body as Retinol Binding Protein (RBP) for epithelial cells. Alcohol can reduce fat soluble vitamins stor…

I'm not going to respond to a good chunk of this even though I'm itching too.

But I just have to laugh out loud at the thought of governments in the 80s not stigmatizing the disease and specifically queer people having anal sex.

Just so laughably the opposite of the real experience of an entire lost generation of gay men.

Re: Moderna’s HIV vaccine has officially begun human trials

#405

Post by refurb »

ausudhz wrote: post #50
mlyle wrote: post #36

Earlier quoted context omitted.

Three things: - This isn't really the reason why mRNA is attractive here (see my other comment above). (Though, ability to iterate/try many protein combinations quickly in animal models was helpful). - Almost no drugs or treatments do we really know the long term picture of. Running studies in a way that lets you detect effects far later in life isn't practical. - When we're talking about treatments to prevent severe…

Not to mention the long term effects of COVID are known and way worst that what a vaccine can give you. Vaccine are building an immune response, they're not drugs that try to cope the symptoms (eg. Panadol) and they are the safest drugs out there. Is so interesting how people eat Panadol and many other drugs like candies (without reading the KNOWN side effects - which are also nasty), while they focus so much on thin…

This is wrong.

Covid has been around for 2 years. The vaccines for 1 year. We don’t know the long term effects of either.

Vaccines were trialed for dengue fever that made the disease worse. Vaccines are NOT “the safest drugs out there”.

Re: Moderna’s HIV vaccine has officially begun human trials

#406

Post by refurb »

epgui wrote: post #59
ausudhz wrote: post #50

Earlier quoted context omitted.

Not to mention the long term effects of COVID are known and way worst that what a vaccine can give you. Vaccine are building an immune response, they're not drugs that try to cope the symptoms (eg. Panadol) and they are the safest drugs out there. Is so interesting how people eat Panadol and many other drugs like candies (without reading the KNOWN side effects - which are also nasty), while they focus so much on thin…

Exactly this. I would rather take the "most unsafe" vaccine of the last 30 years than take an Advil. (I am a biochemist)

I’m a drug developer and I’d rather take an Advil than the vaccine.

Look at Vioxx. It took 4 years on the market before anyone realized it increased the risk of heart attacks.

Advil has been around for decades. It has known risks.

Re: Moderna’s HIV vaccine has officially begun human trials

#407

Post by refurb »

mlyle wrote: post #83
abletonlive wrote: post #69

Earlier quoted context omitted.

Could you elaborate on why you wouldn't take advil?

Not the poster. Advil is pretty safe, but sometimes has horrific effects (e.g. Stevens Johnson Syndrome, catastrophic stomach bleeding, etc.) Also, NSAIDs are shown to slow healing from injury in most cases. Ibuprofen is terrifically useful but also a little scary for something we use so routinely. e.g. some parents gave their 7 year old a motrin, and all her skin sloughed off her body and she had brain damage and lo…

That’s ridiculous since SJS and TENS can happen with pretty much any drug.

And fatal anaphylactic reactions to vaccines aren’t atypical.

Re: Moderna’s HIV vaccine has officially begun human trials

#408

Post by wolverine876 »

Terry_Roll wrote: post #338
Nbox9 wrote: post #198

Earlier quoted context omitted.

CDC backing up this claim. Having an undetectable viral load prevents transmission during sex —- but likely not during needle sharing. The answer to why seems to be an obvious “because there are less virus particles”. I’m linking a couple of scientific studies following couples having condomless sex where one partner is HIV positive, on ART with low viral load. Among the about 2000 couples in these studies there were…

So some other points. Some Sex lubes can make it easier for infections to get into the body. https://en.wikipedia.org/wiki/Personal_lubricant#Water-based Thing is I wonder if a higher vitamin A and zinc intake can help because all epithelial cells need retinol (vitamin A), zinc is needed to move retinol around the body as Retinol Binding Protein (RBP) for epithelial cells. Alcohol can reduce fat soluble vitamins stor…

> Some Sex lubes can make it easier for infections to get into the body. https://en.wikipedia.org/wiki/Personal_lubricant#Water-based

I would not use Wikipedia for health information with serious consequences.

Re: Moderna’s HIV vaccine has officially begun human trials

#409

Post by wolverine876 »

Terry_Roll wrote: post #338
Nbox9 wrote: post #198

Earlier quoted context omitted.

CDC backing up this claim. Having an undetectable viral load prevents transmission during sex —- but likely not during needle sharing. The answer to why seems to be an obvious “because there are less virus particles”. I’m linking a couple of scientific studies following couples having condomless sex where one partner is HIV positive, on ART with low viral load. Among the about 2000 couples in these studies there were…

So some other points. Some Sex lubes can make it easier for infections to get into the body. https://en.wikipedia.org/wiki/Personal_lubricant#Water-based Thing is I wonder if a higher vitamin A and zinc intake can help because all epithelial cells need retinol (vitamin A), zinc is needed to move retinol around the body as Retinol Binding Protein (RBP) for epithelial cells. Alcohol can reduce fat soluble vitamins stor…

> The whole 80's govt advice/warnings on HIV were directed at everyone because they didnt want to stigmatise those engaging in non vaginal intercourse.

Gay people were so stigmatized at the time that the government did nothing when they thought it was a 'gay disease'; they just let an epidemic spread and people die. Very few in the 1980s worried about offending gay people. Once it was spreading to people who weren't gay, then I'm sure health information was provided to those people.

Re: Moderna’s HIV vaccine has officially begun human trials

#410

Post by Terry_Roll »

ev1 wrote: post #368
Terry_Roll wrote: post #338

Earlier quoted context omitted.

So some other points. Some Sex lubes can make it easier for infections to get into the body. https://en.wikipedia.org/wiki/Personal_lubricant#Water-based Thing is I wonder if a higher vitamin A and zinc intake can help because all epithelial cells need retinol (vitamin A), zinc is needed to move retinol around the body as Retinol Binding Protein (RBP) for epithelial cells. Alcohol can reduce fat soluble vitamins stor…

> Anyone who paid attention to the Ebola outbreak in Africa a few years back, may remember that some viruses like Ebola can hide in parts of the body where the immune system can not go, namely the eyes and the testes and sometimes the brain, so they may have remembered that blokes testing negative for Ebola but previously had it, could still be passing it on through semen. You might find this interesting, the "few ye…

Nothing would surprise me! I know a mad scientist who works at the UK's Porton Down, we discussed alot, but the systems are not in place to stop people shipping stuff around. Until such times as that happens, any country with the know how can release anything anywhere.

I think this Hollywood film Dont Look Up will be a poignant message to everyone.

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