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Moderna’s HIV vaccine has officially begun human trials

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Re: Moderna’s HIV vaccine has officially begun human trials

#391

Post by Retric »

mlyle wrote: post #387
Retric wrote: post #383

Earlier quoted context omitted.

I don’t think most peoples 25 year old self can really identify what their 85 year old self will be like. Yet saving for retirement isn’t just about them some time in the future it’s about making you feel better now.

> I don’t think most peoples 25 year old self can really identify what their 85 year old self will be like. Yes, and I believe this is a reason why people make choices that adversely affect their 50 year old self. Who's that guy in the future going to be? Why should I care about making it better for him?

You could say the same thing about people drinking heavily only to wake up the next day with a massive hangover. So it isn’t the differences between them that’s causing people to screw over their future self.

Re: Moderna’s HIV vaccine has officially begun human trials

#392

Post by suifbwish »

biorach wrote: post #328
suifbwish wrote: post #318

Earlier quoted context omitted.

I didn’t say it was not natural. I simply said it would not surprise me if it were not. It’s interesting how even asking a question about things can become taboo.

No one said it was taboo. You made a dumb comment, someone politely explained real science to you.

I merely said I would not be surprised, implying that I am not completely certain everything is as it is always commonly believed. If you feel the comment was dumb that’s your opinion and perhaps others share it but it’s hardly more than an opinion. I am quite aware of what real science is and what hurdles it has gone through for the past several hundred years to rid itself of political inhibition.

Re: Moderna’s HIV vaccine has officially begun human trials

#393

Post by dragonwriter »

selcuka wrote: post #386
xienze wrote: post #129

Earlier quoted context omitted.

> One reason is that mRNA vaccines can be developed much faster than traditional vaccines. So the idea is you have a better chance of "outrunning" a strain. Is that why the response to Delta was "just take another dose of the original formulation" and the response to Omicron was "just take another dose of the original formulation until we have the new one made up in a few months"? And who doesn't see another strain t…

They have trialled variant specific vaccines for both Delta and Omicron. It turned out that the original vaccine is as effective for Delta, so that work was shelved. Omicron, on the other hand, seems to be evading the immunity created by the Alpha vaccine, so they are actually planning to start producing an Omicron specific booster (or more correctly Alpha+Omicron) after FDA approval.

> They have trialled variant specific vaccines for both Delta and Omicron. It turned out that the original vaccine is as effective for Delta, so that work was shelved.

No, it wasn't; in fact, the Pfizer-BioNtech Omicron variant-specifc vaccine and booster trial was announced only a week ago, while Novavax plans to begin testing an Omicron-specific vaccine imminently.

https://www.pfizer.com/news/press-release/press-release-deta...

https://ir.novavax.com/2021-12-22-Novavax-Announces-Initial-...

Re: Moderna’s HIV vaccine has officially begun human trials

#395

Post by joshuamorton »

ifyoubuildit wrote: post #378
joshuamorton wrote: post #324

Earlier quoted context omitted.

I think the place where the disagreement or misunderstanding lies is in how we're describing thinking about unknowns. You seem to be taking this from the perspective that, because there are unknowns, literally anything could happen . And we don't think that's the case with my vaccines or code. Pushing v2 of your webapp to master isn't going to cause rockets to launch. There are things that could happen and there are…

> One such thing is sudden onset symptoms well after the thing has left your system, because there isn't a biological way for that to have an effect The hard part about conversations like this are that you could have written the definitive book on this stuff, or you could be just another dummy on the internet like me. So I have to take a statement like that and do my best to evaluate it myself, since I have no idea h…

> We know for a fact that vaccines have long term effects. They wouldn't be useful otherwise. It would be nice if they could only have positive long term effects, but why would there be any guarantee of that?

Correct, but, and this is the important bit: the only lasting thing the vaccines do is leave your body primed to react to certain proteins (everything else they "do" leaves the body pretty quickly, you can think of this as a fairly limited api they're interacting with). This could be a bad thing, but if it is

1. Anyone who naturally caught covid would also suffer the same consequences

2. you'd expect to see the issues as soon as the immune system was primed, this takes days to weeks, not months.

So yes, there are all sorts of weird thins that could happen, but I'll reiterate: we know of know biological mechanisms that would make those things happen suddenly, without warning, months after the vaccine. We understand, very well, that such things can't really happen.

Just because you don't understand the human body very well doesn't mean the medical establishment also has equally no clue.

Re: Moderna’s HIV vaccine has officially begun human trials

#396

Post by FooBarBizBazz »

mlyle wrote: post #375
hiptobecubic wrote: post #361

Earlier quoted context omitted.

I had no idea "dry sex" was a thing. I am speechless. wtf?

Some cultures believe lubrication is a sign of poor virtue or infidelity. Women use chalk, cornstarch, etc, to ensure they stay dry and to (supposedly) enhance the pleasure of their partner.

It makes zero sense, but yeah.

There was a thing not long ago where talcum powder, I think Johnson & Johnson, had some asbestos contamination (asbestos being another mineral that can come from the same mines, apparently). And people were suing because it gave them cancer of the uterus and other internal parts of the female reproductive system. Which makes you go: Wait a second. How the hell does that happen?

That's how.

Re: Moderna’s HIV vaccine has officially begun human trials

#397

Post by nerdponx »

suifbwish wrote: post #392
biorach wrote: post #328

Earlier quoted context omitted.

No one said it was taboo. You made a dumb comment, someone politely explained real science to you.

I merely said I would not be surprised, implying that I am not completely certain everything is as it is always commonly believed. If you feel the comment was dumb that’s your opinion and perhaps others share it but it’s hardly more than an opinion. I am quite aware of what real science is and what hurdles it has gone through for the past several hundred years to rid itself of political inhibition.

The point is that in this case the common belief happens to agree with science.

Saying something controversial or inflammatory and then accusing other people of getting riled up is pretty much trolling 101.

Re: Moderna’s HIV vaccine has officially begun human trials

#398

Post by throwaway22032 »

jl6 wrote: post #232
Nbox9 wrote: post #198

Earlier quoted context omitted.

CDC backing up this claim. Having an undetectable viral load prevents transmission during sex —- but likely not during needle sharing. The answer to why seems to be an obvious “because there are less virus particles”. I’m linking a couple of scientific studies following couples having condomless sex where one partner is HIV positive, on ART with low viral load. Among the about 2000 couples in these studies there were…

It does sound suspiciously like wishful thinking though, doesn’t it? You can’t sample all parts and all fluids of someone’s body all the time. Maybe trace undetectable levels of the virus can be transmitted, and of course they are going to look like a “no transmission” case if you lack the ability to detect that amount of virus. And that’s either not a problem (if trace levels = no symptoms), or a ticking time bomb w…

We feel fairly comfortable in stating that HIV is not transmissible surface-to-surface despite the mathematical fact that strictly there is some miniscule non-zero chance that it could be, this is basically the same thing.

Re: Moderna’s HIV vaccine has officially begun human trials

#399

Post by rzz3 »

collegeburner wrote: post #321
thebradbain wrote: post #154

Earlier quoted context omitted.

I’m not a doctor, but as a gay man: it’s my understanding HIV doesn’t mutate in the same way a disease like Covid does, at least not in the sense that there’s as many opportunities to spread (i.e. not airborne), so while HIV may actually mutate more in theory, it gets less chances to spread, so less completely-different variants become widespread. Also, as part of “stopping the spread” PrEP has existed for years. It’…

Because most straight people don't need it, risk is much lower. Truvada is nephrotoxic and that's bad in the long term, many drugs are bad if taken for long periods. Condoms have no such side effects.

Discovy is not, or much less so.

Re: Moderna’s HIV vaccine has officially begun human trials

#400

Post by rzz3 »

im3w1l wrote: post #80
f6v wrote: post #56

Earlier quoted context omitted.

I think slowly will come the realization that mRNA vaccines aren’t as fast to develop as people thought. Sputnik/AstraZeneca vaccines were released almost at the same time as Moderna/Pfizer. Yes, the latter were first commercial mRNA vaccines, but the technology is nevertheless rather mature. I watched a lecture by the people credited with creating mRNA vaccines and it turns out people have been working on the techno…

The slow part is the safety testing right? If we had a robust enough theory of vaccines safety we could reduce that. How are the yearly flu shots tested anyway? Now, I would not take such a HIV shot. But for high risk groups, think promiscious homosexuals, it may eventually be worth it.

If we can do it this fast and this safely for COVID, we should do the same for this disease.
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