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Moderna’s HIV vaccine has officially begun human trials

them.us

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Re: Moderna’s HIV vaccine has officially begun human trials

#171

As I understand it, the reason an HIV vaccine has been so difficult to create is that HIV mutates so easily. I understand the basics behind how mRNA vaccines are generated, but I don't understand why this approach would be expected to have any more success in evading the high mutation potential of HIV than other vaccine types. After all, it was even a concern with new coronavirus variants that the original Moderna va…

I’m not a doctor, but as a gay man: it’s my understanding HIV doesn’t mutate in the same way a disease like Covid does, at least not in the sense that there’s as many opportunities to spread (i.e. not airborne), so while HIV may actually mutate more in theory, it gets less chances to spread, so less completely-different variants become widespread. Also, as part of “stopping the spread” PrEP has existed for years. It’…

Small correction: PrEP (pre-exposure prophylaxis) and PEP (post-exposure prophylaxis) are both protocols for using drugs to prevent infection. You generally take PrEP drugs every day if you think you're in danger of being exposed, or alternatively take PEP if you think you have been exposed to HIV without any kind of protection, sort of like a morning after pill (but every day for a whole month).

Re: Moderna’s HIV vaccine has officially begun human trials

#172

Earlier quoted context omitted.

And undetectable === untransmittable. Just in case people here didn't know.

I didn't know this. Could you explain the reason?

No detectable virus means no transmissible virus.

Re: Moderna’s HIV vaccine has officially begun human trials

#173
Last night I read this Nature review paper [1] and this history article [2] that describe the parallel investigations in both mRNA technology and lipid nanoparticle technology that ultimately led to the development of mRNA based vaccines. As we come up on Nobel Prize season, the second article is particularly interesting if you want to get a preview of some of the possible recipients.

[1] https://www.nature.com/articles/s41578-021-00358-0 [2] https://www.nature.com/articles/d41586-021-02483-w

Re: Moderna’s HIV vaccine has officially begun human trials

#176

The them.us article [0] says: > but we’ll be praying ... that by next year, LGBTQ+ communities around the globe will have a new reason to celebrate. This perpetuates the myth that HIV is mainly a problem for gay people. Can we change to another article, such as [1]? The Bill & Melinda Gates Foundation supports Moderna's HIV vaccine research [2]. [0] https://www.them.us/story/hiv-aids-vaccine-human-trials-mode... [1]…

More like it perpetuates the myth that LGBTQ+ is a monolithic group.

HIV is more concerning for Gay men for a variety of reasons. There is nothing wrong with pointing out the obvious. Ask anyone who takes prep.

Re: Moderna’s HIV vaccine has officially begun human trials

#177
post #174

Since the mRNA covid vaccines seem to only work for 90-180 days, why would a vaccine for anything else be different?

I don't know anything about vaccines or their validity, but even then, the current solutions are a shot once a month or PrEP every day... so twice a year sounds pretty great to me?

Re: Moderna’s HIV vaccine has officially begun human trials

#178

The them.us article [0] says: > but we’ll be praying ... that by next year, LGBTQ+ communities around the globe will have a new reason to celebrate. This perpetuates the myth that HIV is mainly a problem for gay people. Can we change to another article, such as [1]? The Bill & Melinda Gates Foundation supports Moderna's HIV vaccine research [2]. [0] https://www.them.us/story/hiv-aids-vaccine-human-trials-mode... [1]…

It seems to be an LGBTQ-focused website, so it looks to be doing nothing more than viewing things from the viewpoint of (presumably) its biggest reader base...

Re: Moderna’s HIV vaccine has officially begun human trials

#180
post #176

The them.us article [0] says: > but we’ll be praying ... that by next year, LGBTQ+ communities around the globe will have a new reason to celebrate. This perpetuates the myth that HIV is mainly a problem for gay people. Can we change to another article, such as [1]? The Bill & Melinda Gates Foundation supports Moderna's HIV vaccine research [2]. [0] https://www.them.us/story/hiv-aids-vaccine-human-trials-mode... [1]…

More like it perpetuates the myth that LGBTQ+ is a monolithic group. HIV is more concerning for Gay men for a variety of reasons. There is nothing wrong with pointing out the obvious. Ask anyone who takes prep.

Your comment perpetuates the myth that gay men as a group are a homogenous whole.

More specifically HIV, it's more of a concern for non-monogamous gay, and bisexual, men who engaging in unprotected anal intercourse.

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