Moderna’s HIV vaccine has officially begun human trials

dogma1138 wrote: post #5

Why is the comment with the actual press release that honestly gives far better info flagged to death? @Dang can you fix this?

Interestingly their five link submissions are all dead as well. I'm guessing it was some kind of automated response based on the account history.

Re: Moderna’s HIV vaccine has officially begun human trials

#8

Post by echelon » Mon, Jan 31, 2022, 6:14 PM UTC

rubyist5eva wrote: post #6

> We could be getting even closer to stopping the spread of HIV/AIDS. Not if it's anything like the Covid-19 vaccines that don't stop someone from contracting or spreading it.

70% prevention is better than 0%, and something tells me that it will see a much higher rate of adoption than the Covid vaccine.

Re: Moderna’s HIV vaccine has officially begun human trials

#9

Post by gameswithgo » Mon, Jan 31, 2022, 6:14 PM UTC

rubyist5eva wrote: post #6

> We could be getting even closer to stopping the spread of HIV/AIDS. Not if it's anything like the Covid-19 vaccines that don't stop someone from contracting or spreading it.

The covid-19 vaccines were very effective at preventing disease and spread until the omicron mutation, which perhaps wouldn't have happened if not for vaccine hesitancy. (but that is an inevitable human nature thing, so you have to accept it and deal with)

Fortunately the vaccines were still very effective at preventing death and hospitalization with omicron, I wonder how many lives were saved overall, so far? It is really quite remarkable.

Given the slower way HIV spreads we have a much better chance at actually getting rid of it. Its not flying around in the air mutating in a billion people at once every day.

Re: Moderna’s HIV vaccine has officially begun human trials

#10

Post by hn_throwaway_99 » Mon, Jan 31, 2022, 6:15 PM UTC

As I understand it, the reason an HIV vaccine has been so difficult to create is that HIV mutates so easily. I understand the basics behind how mRNA vaccines are generated, but I don't understand why this approach would be expected to have any more success in evading the high mutation potential of HIV than other vaccine types. After all, it was even a concern with new coronavirus variants that the original Moderna vaccine would be less effective against them (and, indeed, while the original vaccine is still highly effective against all variants, my understanding is that it is less so than the original variant). And SARS-COV-2 mutates much less easily than HIV.

Can someone with more knowledge explain the thought process behind this?