Earlier quoted context omitted.
Physicists don't largely choose physical theories on whether they make life meaningful or not. I think you're thinking of religious people.
I'm not. Otherwise why would physicists support the concept of free will so strongly without any evidence for it. It is borderline religious. The video I posted above says as much.
The reason that super determinism is rejected is because (in the usual understanding) that it requires that the initial state of the universe is set up incredibly precisely to make all subsequent measurements appear to violate Bell's inequality, even though reality isn't actually like that.
So if we set up a quantum measurement and make a decision based on photons of light emitted from distant stars, the experimenter deterministically chooses to make just the right measurement that would make the universe look like it was violating the inequality. Including all the matter between us, and the atoms in the neurons in the experimenters brain, and the photons that were emitted before any of that existed.
This is why super determinism is rejected. It would mean that we are not "free" to choose the experiments and measurements we perform. The universe would be essentially conspiring to deceive us at all levels, including what science we do, the results we receive and the conclusions drawn from it. Which is why it would invalidate the scientific method itself. We couldn't trust anything we thought we knew.
Sabine has a different take from what I can tell. If you allow backwards causality, the measurement act is not independent of the thing being measured. See this blog entry and the comments:
http://backreaction.blogspot.com/2019/07/the-forgotten-solut...