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An Experience with Modafinil

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Re: An Experience with Modafinil

#251

Post by replwoacause »

So weird... I just had a dream about Modafinil last night for no apparent reason and then I wake up to see this post on HN. What an odd coincidence.

I haven't thought about Modafinil in years but back when 'Limitless' came out and I was in my mid-twenties I experimented with it very briefly, along with a host of other "nootropics", but the risk of Stevens-Johnson syndrome put me off of it pretty quickly. It still shocks me when I think about how foolhardy I was to order this Rx drug from overseas.

Re: An Experience with Modafinil

#252

Post by pram »

znowcone wrote: post #218
asdff wrote: post #53

Earlier quoted context omitted.

It makes a great stack with a sativa however. The hippy speedball.

Of all stimulants, caffeine must be the worst one to combine with THC. Proper stimulants like amphetamine or methylphenidate on the other hand... A word of warning though, it's much more dangerous and my normal Wednesday (1/8oz weed and 40mg mph) can be your psychosis.

Yes I agree, I once drank a load of coffee and did some THC gummies and it caused very unpleasant hallucinations and voices in my head. Also I couldn't fall asleep to make it go away :V

Re: An Experience with Modafinil

#253

Post by rahoulb »

samatman wrote: post #220
pengaru wrote: post #82

Earlier quoted context omitted.

> 80% of people couldn't distinguish I.V. cocaine from I.V. caffeine in some study I am unable to locate at the moment, which I think involved Nora Volkow from NIH, either as PI or collaborator. All this tells me is that I'm clearly consuming caffeine incorrectly in the form of coffee and/or tea.

Or, and hear me out, people outside of cocaine's traditional region are using it wrong. The past being a different country, I was fortunate in the early Noughts to be able to purchase Bolivian coca tea bags from an early online drug dealer called Amazon dot com. They were a fantastic addition to the tea shelf. I would favor a cup of the coca tea when energy was low going into an evening with social plans. Even, brigh…

> How does that compare to refined cocaine taken intranasally?

Immediate, bright energy, short acting (duration is half hour), feel it fading within minutes (which is why you want more)

Re: An Experience with Modafinil

#254

Post by Loughla »

Trasmatta wrote: post #17

I sort of fell down the rabbit hole of nootropics over the past year, of which Modafinil is a frequent recommendation. I don't know if I would really recommend nootropics to the average person (because there is risk involved, and many of these substances have had very little in the way of human studies), but it's been an interesting journey. It was kind of a pandemic hobby I picked up. My favorites are Aniracetam and…

The only thing that bothers me about nootropics is that so much of the conversation is about productivity. What a weird thing to focus on, especially when we're talking about un-researched brain chemistry impacts.

The best combination I found was magnesium, ashwaganda, and green tea extract. It caused massively vivid, lucid dreams.

I've never had more fun sleeping, and my sleep health was never better. It had nothing to do with productivity, and was literally just so I could fly and shoot fire out of my hands in my dreams.

Re: An Experience with Modafinil

#255

Post by trasz »

kortex wrote: post #250
CoastalCoder wrote: post #236

Earlier quoted context omitted.

Asking as a layman: What's the current understanding as to why modafinil and stimulants affect different people so differently?

Paradoxical and other unusual effects can occur with any kind of drug. Brain drugs in particular seem to be prone to a wide variance in the effect profile. I speculate that in part it is due to the heavy "reuse" of neurotransmitters for various purposes (neurotransmitters themselves being mostly reused modified amino acids). For example, dopamine modulates motor activity, reward pathways, attention, and error correct…

Sorry for off-topic, but: why are there many different neurotransmitters instead of a common single one? (I mean, sure, evolution, there's no "why", but I'm asking from an hypothetic engineering standpoint.)

Re: An Experience with Modafinil

#256

Post by iammjm »

I've been using Modafinil daily for about 2,5 years and I am currently under its effect. I buy it online and pay with Bitcoins. I use armodafinil if I want more focus, and I use modafinil if I am tired. I don't take the full dose, which is 150mg (armodafinil) /200mg (modafinil)- I break the tablets into 4 and pop them if I feel like I am unfocused or tired. In the course of the day, I rarely take more than 1 full dose. For reference, I know of people who take it for narcolepsy who routinely consume 8 full doses a day (200mg x 8). For me it's been a clear net benefit without any noticeable side effects. I think it makes me about 20% "smarter"/"better", let's me learn and achieve more and generally improves my life.

Re: An Experience with Modafinil

#257

Post by buscoquadnary »

randstring wrote: post #247
bserge wrote: post #190

Earlier quoted context omitted.

I've had cocaine a few times now and while everyone is saying it's euphoric, I keep saying it's the most normal I've ever felt. Not "euphoric", I've done other stuff that felt suuuuper good (in an actual euphoria sense) so I believe can compare. But normal . The cloud of thoughts gone, I am able to make myself do anything with one thought, I have energy, the aches are gone, the tinnitus is gone, I don't second guess,…

I've tried cocaine and it would make me feel like the "best" or perhaps much better version of me. Improved, but subjectively not overinflated self-confidence, sharper thoughts, better concentration, high energy and motivation, easier connection to people, without apparent intoxication or affected judgement. I would agree with you that it makes me feel normal in the sense that's what it seems I should have been. The…

That's exactly how I feel when I take my Adderall. Or at least how I do after a break. I also have ADHD so that probably means you've got it to.

Re: An Experience with Modafinil

#258

Post by kortex »

actually_a_dog wrote: post #206
robinduckett wrote: post #160

Earlier quoted context omitted.

Time to mainline it directly into your eyeballs

In all seriousness, taking it sublingually might actually be extremely effective. Sublingual delivery tends to be more effective with lipophillic substances than hydrophilic substances. Caffeine is a bit weird in that it is hydrophilic, but, it is sufficiently lipophyllic to cross cell membranes and penetrate the blood/brain barrier, which is what makes me suspect it would work out well.

Sublingual caffeine is definitely a thing. There is caffeinated gum you can get on Amazon. You can feel it kick in almost immediately.

Re: An Experience with Modafinil

#260

Post by ianbutler »

yc-kraln wrote: post #166
ianbutler wrote: post #67

A friend of mine has used this before and they did alternating low ~30mg doses that same someone had previously used a similar dose Adderall in highschool and early college and preferred the feeling of Modafinil. They told me they had read multiple studies before hand as well as personal accounts (such as from the venerable https://www.gwern.net/ ). That person told me that the feeling was less intense but enough to…

I used to describe Modafinil as "the best sleep you ever had, in pill form". As someone with chronic sleep issues and ADHD, it allowed me to function during some of the worst months of my life. The way I eventually settled on to 'dose' Modafinil is two pills (200mg) on Monday morning, then one pill on Wednesday morning; this kept my serum levels at a level where I got the positive effects for a whole work week, yet c…

Yeah they said their usage of it is very much, a "break glass" kind of deal where only when things are really crazy.
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