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An Experience with Modafinil

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Re: An Experience with Modafinil

#151

Post by refurb »

inter_netuser wrote: post #59
ipnon wrote: post #49

What's remarkable to me is that modafinil is less toxic than caffeine[0], and possibly even less addictive[1], but we all know which is illegal for recreational use and which is coffee. Regulations are sticky. The FDA follows the precautionary principle. Political game theory incentivizes restricting what the electorate can do rather than giving them more freedoms, and being blamed for whatever harm may fall upon the…

Caffeine would be illegal to possess, if it were invented yesterday. 80% of people couldn't distinguish I.V. cocaine from I.V. caffeine in some study I am unable to locate at the moment, which I think involved Nora Volkow from NIH, either as PI or collaborator.

Cocaine was isolated long before current drug laws, so I'm not sure I buy the argument "if it were invented today". Cocaine wasn't invented today and was banned.

Re: An Experience with Modafinil

#152

Post by pfortuny »

xboxnolifes wrote: post #91
marcan_42 wrote: post #75

Earlier quoted context omitted.

Maybe school shouldn't be a competition with winners and losers.

School is just a part of life, and life has limited resources. There will always be winners and losers. At least, until (and if) we reach a point where the total sum of resources exceeds the total demand for them.

Is the score what makes a student a winner, though? That is what parents have to learn to curb.

Re: An Experience with Modafinil

#153

Post by callamdelaney »

diamondlovesyou wrote: post #119
brotchie wrote: post #12

Modafinil is a pretty amazing drug. The come down after one use isn’t too bad. But if you’ve been using it daily for a week, the comedown is BRUTAL: pretty much feel like you have zero energy and feel like laying prone for 8 hours. Once did 48 straight awake on it and felt wide awake 36 hours in… Distinctly remember the 1st time I took it. Was perhaps 8pm at night and I swore it was 8am in the morning and I’d just ha…

Funny. The couple of times I took Modafinil, it might as well have been placebo. Absolutely no effect. I gave the pills away. I have ADD, and am prescribed 60mg Adderall XR/day. OTOH, I have slept on 30mg Adderall XR a couple of times, so maybe I'm just "built differently" w.r.t. The Stimmies.

Brand can affect this according to anecdotes on /r/modafinil/

Re: An Experience with Modafinil

#154

Post by rflrob »

inter_netuser wrote: post #59
ipnon wrote: post #49

What's remarkable to me is that modafinil is less toxic than caffeine[0], and possibly even less addictive[1], but we all know which is illegal for recreational use and which is coffee. Regulations are sticky. The FDA follows the precautionary principle. Political game theory incentivizes restricting what the electorate can do rather than giving them more freedoms, and being blamed for whatever harm may fall upon the…

Caffeine would be illegal to possess, if it were invented yesterday. 80% of people couldn't distinguish I.V. cocaine from I.V. caffeine in some study I am unable to locate at the moment, which I think involved Nora Volkow from NIH, either as PI or collaborator.

Is this the study? “The mood effects but not the physiological effects of intravenous caffeine were similar to those previously observed with cocaine in studies using similar methods and subjects.”

https://pubmed.ncbi.nlm.nih.gov/7714788/

Re: An Experience with Modafinil

#155

Post by senectus1 »

the_only_law wrote: post #150
senectus1 wrote: post #7

Earlier quoted context omitted.

used to do this a lot. still recovering from it. I suspect my mind is permanently damaged in subtle ways from this behaviour. either that or 47 is "wind down time" for my brain

Yeah this is probably not too far from my daily routine, except replace coffees with energy drinks. Though I oversleep significantly on the weekends (normally aided by the effects/after effects of shit that’s worse for my brain). It very obviously has major negative effects, but I just can’t bring myself to change it. I’ve tried once or twice, but I always return to this. If life was a little more flexible, I think I…

A bit like exercise you need to :

a) be fairly rigid with it

b) turn it into a habit.

If you don't you're going to have burn out. not just emotionally but physically. I had a fit that the Dr put down to poor sleep and eating habits. It took me weeks to get over the immediate effect of the fit, I felt like I'd been worked over with a baseball bat.

I used that recovery time to go cold turkey on caffeine (if I'm going to feel like crap i might as well have a good reason for it), I limit myself to tea only now, and only 1-3 cups a day. I eat a lot better and I go bike riding a few times a week. I get at least 6 1/2 hours a sleep a night, and aim for 7-8.

its worth noting that while there is evidence for sleep debt, there is no evidence that oversleeping helps correct it.

Re: An Experience with Modafinil

#156

Post by malfmalf »

inter_netuser wrote: post #59
ipnon wrote: post #49

What's remarkable to me is that modafinil is less toxic than caffeine[0], and possibly even less addictive[1], but we all know which is illegal for recreational use and which is coffee. Regulations are sticky. The FDA follows the precautionary principle. Political game theory incentivizes restricting what the electorate can do rather than giving them more freedoms, and being blamed for whatever harm may fall upon the…

Caffeine would be illegal to possess, if it were invented yesterday. 80% of people couldn't distinguish I.V. cocaine from I.V. caffeine in some study I am unable to locate at the moment, which I think involved Nora Volkow from NIH, either as PI or collaborator.

Maybe this is the study? First result in google for "cocaine caffeine comparison"

https://pubmed.ncbi.nlm.nih.gov/25414797/

or this :

https://www.beveragedaily.com/Article/2002/09/02/Coffee-acts... https://www.purdue.edu/newsroom/releases/2016/Q4/mixing-ener... https://www.purdue.edu/newsroom/releases/2016/Q4/mixing-ener...

they seem to imply something similar what you are stating

this one found no such effect on rats:

https://www.sciencedirect.com/science/article/abs/pii/S01497...

and most of the articles I found say that caffeine INCREASES the effect of caffeine

Re: An Experience with Modafinil

#158

Post by reshie »

dpark wrote: post #131
xyzzy123 wrote: post #121

Earlier quoted context omitted.

OK, I don't have any data either but I'd be pretty surprised if there were a lot of murders by people trying to acquire cocaine. I mean, it could be true? If you were seriously addicted but not high at the time, I expect you might feel agitated, but also kind of sorry for yourself / miserable and not so much in a murdering frame of mind. Large amounts of money (which large amounts of cocaine can be exchanged for), on…

Honestly I don’t know how prevalent murdering for drug money is at all. My belief that this happens with some regularity for cocaine is based on suspect info now that I think about it. The DARE program told me that definitely 100% of illegal drug users eventually turn to murder to acquire more, but that might have been an exaggeration.

i too think its more about the economics of it. Territory and business with in the criminal element is cut throat.

Re: An Experience with Modafinil

#159

Post by inter_netuser »

malfmalf wrote: post #156
inter_netuser wrote: post #59

Earlier quoted context omitted.

Caffeine would be illegal to possess, if it were invented yesterday. 80% of people couldn't distinguish I.V. cocaine from I.V. caffeine in some study I am unable to locate at the moment, which I think involved Nora Volkow from NIH, either as PI or collaborator.

Maybe this is the study? First result in google for "cocaine caffeine comparison" https://pubmed.ncbi.nlm.nih.gov/25414797/ or this : https://www.beveragedaily.com/Article/2002/09/02/Coffee-acts... https://www.purdue.edu/newsroom/releases/2016/Q4/mixing-ener... https://www.purdue.edu/newsroom/releases/2016/Q4/mixing-ener... they seem to imply something similar what you are stating this one found no such effect on rat…

caffeine increases effects of cocaine, you mean?

That's expected, there is a reason why it's most common cocaine adulterant, along with lidocaine.

People cutting it probably read the same studies.

Re: An Experience with Modafinil

#160

Post by robinduckett »

pengaru wrote: post #82
inter_netuser wrote: post #59

Earlier quoted context omitted.

Caffeine would be illegal to possess, if it were invented yesterday. 80% of people couldn't distinguish I.V. cocaine from I.V. caffeine in some study I am unable to locate at the moment, which I think involved Nora Volkow from NIH, either as PI or collaborator.

> 80% of people couldn't distinguish I.V. cocaine from I.V. caffeine in some study I am unable to locate at the moment, which I think involved Nora Volkow from NIH, either as PI or collaborator. All this tells me is that I'm clearly consuming caffeine incorrectly in the form of coffee and/or tea.

Time to mainline it directly into your eyeballs
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