* tobacco (completely banned, I don't think there's any reasonable amount of tobacco its users could use where its positive aspects outweigh the negative)
* alcohol
* sugar (this is a super complicated thing and it would have to include controlling how much added sugar each food has, what kinds of food are even allowed to have sugar in them - sauerkraut isn't supposed to have any sugar, US! - plus probably some active measures both positive and punitive against morbid obesity)
* all recreational and non-recreational drugs
* coffee/caffeine and all associated beverages
* probably vaping
Yes, this will probably take all fun in (current) life, we'll need to find new ways to have fun without these substances. We're quite smart, I'm sure we'll find a way. We'll just need to re-architect our societies, ergo "social evolution"/"50+ years from now").
But otherwise I don't think it's feasible to live 120+ years and to have everyone fully functional. It would probably also help those fallen on hard times (this would also require that everyone becomes much better at exercising their empathy, which is probably the > hard problem here).
Again, just because this doesn't sound like a fun world or a world you'd want to live in, it doesn't mean it couldn't be. Just like with everything about the future, it could just be a failure of imagination: > can't see how that could be, but people in the future might be able to make it work in new and interesting ways.
I imagine that 200 years from now we might look back at using all these substances as something as dumb as drawing blood with leeches for a migraine or something.