Live data from Hacker News

Israel Finds Fourth Covid Booster Is Ineffective

healthpolicy-watch.news

241–250 of 272 posts

Re: Israel Finds Fourth Covid Booster Is Ineffective

#241

Earlier quoted context omitted.

Unfortunately it turns out that the way vaccination effectiveness is measured could create this apparent effect even in the case that the vaccination was saline. This sounds absurd and wrong, but, as is sometimes the case with statistics, it's possible. Prof Norman Fenton has described the issue and also demonstrated it visually in Excel: https://twitter.com/profnfenton/status/1460339552397275149 https://probabilitya…

> number of days between first immunization and COVID diagnosis Survivorship bias. People end up in this graph because they got a COVID diagnosis after the first immunization, but before getting the second immunization. That's only a very short time window on most vaccination schedules (3-6 weeks), so the only surprise here is that there is a long trail of people who got the first shot and then held off on the second…

People not getting second shots is not a surprise, anyone who has a bad reaction to the first will do that. The lack of any proper tracking of such reactions means it has to be inferred from the data, but the explanation there is fairly obvious.

W.R.T. taking it down, if public health statistics is open to misinterpretation they should explain why and how to correctly interpret it. Doing that sort of work is the reason we have statistical agencies in the first place.

W.R.T. survivorship bias, you seem to be implying that the shape of the graph is expected for any such plot for any vaccine? I don't quite understand what argument you're getting at, sorry. Could you be more explicit? If we zoom in then there's a clear wave shape in which after immunization cases quickly peak at 1000/day about a week after the first shot, then declines again. This is very different to the same data plotted from date of second immunization, where we see a small wave that subsides (same pattern) but then the much bigger one as immunity wears off after about 180 days.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#242

Earlier quoted context omitted.

"You are misinformed. There is a paucity of data supporting boosters, " I think the misinformation might be your own here, or rather, at least based on the time frame. In September, there was little data, because very few had their 3rd shot. Now, we have Omicron - a huge, new, material development - and - large numbers of people with their 3rd shots. Here is some fairly definitive data from one source [1] which clear…

Unfortunately it turns out that the way vaccination effectiveness is measured could create this apparent effect even in the case that the vaccination was saline. This sounds absurd and wrong, but, as is sometimes the case with statistics, it's possible. Prof Norman Fenton has described the issue and also demonstrated it visually in Excel: https://twitter.com/profnfenton/status/1460339552397275149 https://probabilitya…

I don't think either of your examples of stats shenanigans apply here.

And also: " there's increasing amounts of evidence that they may have some sort of immunosuppressive effect"

No, you don't get to say vaccines have an immunosuppressive effect without providing evidence for that.

If you have evidence that vaccines have some sort of immunosuppressive effect then you have to provide it, peer reviewed, not 'some guy blogged it'.

...

1) In terms of 'Dead Time Bias' - well, that doesn't apply if we are looking at daily data points of cases from the rates of those who contract COVID among vaxxed/unvaxxed population.

There is no 'dead time' artefact by that kind of measure.

We're looking at a large group of people, and watching who gets covid and not on a daily basis.

If we were looking over larger time periods, it would start to play a factor. But especially for case counts, then all persons who 'get covid' on a particular day have obviously 'survived' to be in the sampled cohort on that day.

2) The links to Prof Fenton's data is interesting, but flawed.

a) Particularly for infection and not mortality - rates of the former are very low among the general population for both vaxxed and unvaxxed. The 'distortion effect' due to delayed reporting in infections, is not really going to be a big deal.

b) The distortion fades as quickly as the reporting delay. So the effect is null 1 week after vaccination rates stabilise (by his example of 1 week delay). His own 'real world data' comparison show vaccine effectiveness waning over a much longer periods.

3) The 'Datacrime' substack is rubbish, right from the start.

In his examples, he tries to show that, if you don't count positive covid cases during the two weeks after the booster as belonging to the 'booster cohort' and instead group those positive cases into the '2 dose' cohort, then you get a false positive vaccine effectiveness for the booster.

The obvious failure in his reasoning, would be that people would use for the 'numerator' a group of people counting as 'boosted' after a 2 week waiting period ... but then using for the 'denominator', using time at which people receive the jab to count them as boosted.

Obviously if you count people as 'boosted' for a time period (in the denominator, at the moment they get the jab) ... and then move 'positive covid cases' out of that group into the '2 dose' group ... data will be skewed.

I think it's a ridiculous thing to assume.

Why on planet earth would people use two different criteria for 'who is boosted' literally in the same calculation. That would be stupid.

The implication that health authorities 'count as boosted' anyone who received a jab, but then only count COVID cases based on 'received a jab + 2 weeks' makes no sense at all.

As far as I can tell, it seems that health authorities are using the 'jab + 2 weeks' as the definition of 'who is boosted' in all calculations.

By that obvious criteria, then this 'saline solution data misrepresentation' goes away. At least as presented in this article.

I seenno evidence that Health authorities are doing otherwise.

...

I will trade you a 'Boriquagato' for a 'Brandollini': "Brandolini's law, also known as the bullshit asymmetry principle, is an internet adage that emphasizes the difficulty of debunking false, facetious, or otherwise misleading information:[1] "The amount of energy needed to refute bullshit is an order of magnitude larger than is needed to produce it."

Re: Israel Finds Fourth Covid Booster Is Ineffective

#243

Earlier quoted context omitted.

It's a bit conspiratorial to suggest health authorities including epidemiologists and immunologists would 'ignore' a foundational aspect of their underlying knowledge of the system when trying to understand it and formulate policy. Of course they are taking it into account. Most health authorities do random sampling to try to get an idea of underlying natural immunity and the various characteristics that takes on.

If you go by the CDC’s hesitancy in accepting natural immunity, including the number of dubious conducted and/or worded studies they pushed, while ignoring studies showing the opposite and what foreign governments were doing (eg 3G), one is forgiven for believing that.

I didn't say that they were right or wrong to reject natural immunity, I said they are not ignoring natural immunity in terms of their calculus.

FYI The reason we're not going to accept 'natural immunity' as a legit form of documented immunity is because millions of idiots will go and get COVID on purpose , as they'd prefer getting it 'the natural way' as opposed to getting a jab.

This is the difference between 'Science' and 'Public Health Policy'.

I just had an anti-vaxx colleague do exactly that, and it wasn't even for some kind of immune benefit, rather, 'just to get it over with'. I was completely floored when she told me.

But I'm now convinced that my anti-vaxx cousins who are now barred from the liquor stores, would get COVID 'on purpose' if they could get their passport to alcohol and not have to get the 'Goddam Fauci Jab'.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#244

Earlier quoted context omitted.

There are tens of millions of unvaccinated in the US alone. Plenty of data to be had.

But the meaningful data which is increased illness severity and higher chances of death are concentrated in 65+ age brackets which are 95%/88%/62% (1/2/3 shot vaccinated) in the US. As you fall in ages it’s less % vaccinated, but also the chance of a severe case among the unvaccinated drops too…dramatically. So yes, tens of millions unvaccinated, but also tens of millions that can’t really be measured as effectively…

If we can have statistically valid results from 40k clinical trial participants, 5% of the 65+ population being unvaccinated is plenty of data to base conclusions on.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#245

Earlier quoted context omitted.

Unfortunately it turns out that the way vaccination effectiveness is measured could create this apparent effect even in the case that the vaccination was saline. This sounds absurd and wrong, but, as is sometimes the case with statistics, it's possible. Prof Norman Fenton has described the issue and also demonstrated it visually in Excel: https://twitter.com/profnfenton/status/1460339552397275149 https://probabilitya…

I don't think either of your examples of stats shenanigans apply here. And also: " there's increasing amounts of evidence that they may have some sort of immunosuppressive effect" No, you don't get to say vaccines have an immunosuppressive effect without providing evidence for that. If you have evidence that vaccines have some sort of immunosuppressive effect then you have to provide it, peer reviewed, not 'some guy…

I just did provide evidence for it, from a public health agency. You haven't given any justification for why you think that data was wrong. At least majewsky implies a specific problem (albeit I didn't understand what they think it is).

That's as good as it's possible to get because academics don't have access to the raw data with the correct definitions, so there can be no peer reviewed evidence. Not that peer review is any good anyway.

"that doesn't apply if we are looking at daily data points of cases from the rates of those who contract COVID among vaxxed/unvaxxed population. There is no 'dead time' artefact by that kind of measure. Especially for case counts, then all persons who 'get covid' on a particular day have obviously 'survived' to be in the sampled cohort on that day."

It does apply. Those populations are still classified as vaxxed/unvaxxed in a way that creates immortal time bias. Perhaps the explanation I give above isn't clear enough, but any classification system in which someone is assigned to a group some time after the intervention for that group actually started will have this problem. This was true both for the trials but also all government released stats (except it seems, those Alberta graphs which were so rapidly pulled).

Again with cases this time: if you take the vaccine then it's not possible for you to be considered infected within the first two weeks after the shot, because if you were, that infection would be allocated to the unvaccinated cohort. This creates an "infection free period" for the vaccinated which would create an appearance of effectiveness even if the vaccine were a placebo.

Fenton talks about it in the form of 'delayed reporting', but the underlying issue is more likely to be immortal time.

"The distortion fades as quickly as the reporting delay. So the effect is null 1 week after vaccination rates stabilise (by his example of 1 week delay). His own 'real world data' comparison show vaccine effectiveness waning over a much longer periods."

They didn't stabilize yet, did they? The vaccination campaign proceeds in waves in which new people are constantly becoming eligible, for the initial shots and then the boosters.

His point is that for as long as we're doing this we will see what looks like fast-fading efficacy and we would see this even if the vaccine did nothing. We would also see the impossible data artifacts found in the ONS data, like vaccination increasing the non-vaccinated risk of non-COVID deaths. It's extremely problematic that this problem exists and creates the exact patterns in the data that are being used to drive the campaign forward.

"The implication that health authorities 'count as boosted' anyone who received a jab, but then only count COVID cases based on 'received a jab + 2 weeks' makes no sense at all."

That's his point. It doesn't make sense but that's what they do.

When calculating how many people have been boosted by a given date, they report the total number of booster shots actually administered up to that point, because that's what their total records show. They aren't subtracting the number of people who received it recently. But when classifying the status of someone specific who has been infected/hospitalized/died, they classify people who have received a booster dose within the past 2 weeks as double vaxxed (because, they claim, it doesn't have any effect until 2 weeks later). And then when they sum those specific reports it creates immortal time, just phrased differently. You can see the effects of it in the ONS stats where you see the artifacts Fenton describes.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#246

Earlier quoted context omitted.

The vaccinated still get and spread COVID and it is quite possible vaccinated individuals may actually contribute more than unvaxxed to more dangerous variants.

New variants need more mutation cycles. If vaccines slow down transmission (what they do) then they contribute to lower probability of emergence of new variants.

There is already plenty of proof that vaccines cause viruses to mutate to become more virulent, and with Omicron transmission and replication are not being slowed down like before. In fact, recent studies show triple-vaxxed more likely to get Omicron than unvaxxed.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#247
post #23

Earlier quoted context omitted.

I think they are making these strain specific boosters. But it seems “they”* want to keep it quiet until they are ready to release them. My first through on this is that there is over-supply of the OG vaccine and it takes time to switch production and the booster story is designed to give some hope and confidence to the masses (which is good I think). There is also some paperwork involved which takes time, but as we…

Over-supply? A lot of third world countries would be happy to take it. We're still far from offering the entire world even their first shot

yes but these are for-profit companies and the developing world can't pay for those doses so what's the point to Pfizer?

That's a cynical take, but tbf don't the vaccines require logistical infrastructure that those parts of the world don't have? Other vaccines like j&j are perhaps more appropriate for that reason.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#248
post #145

Rochelle Walensky, the CDC director, has stated that vaccines do reduce severity, but they do not stop transmission. Assuming her words represent the scientific and expert opinion, could someone offer a coherent argument as to why there is so much pressure for others to get vaccinated? Is fear of the unvaccinated clogging up hospitals the primary motivation?

> Is fear of the unvaccinated clogging up hospitals the primary motivation? Yes? Hasn't it always been? Beds in ICUs are the main limiting factor of how much Covid we can handle. Lowering hospitalisations is great, that way it can end up as "just a bad flu" we have ( as in, a virus that's present, and spreading, and people get it, and some unfortunate people die from it, but doesn't grind whole countries to a stop).

that sounds revisionist to me. If that were the reason for (attempted) vaccine mandates then why do vaccine advocates feel the need to compel young, healthy people who have a vanishingly small chance of hospitalization to vaccinate? The story has always been about reducing spread.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#249
post #55

Earlier quoted context omitted.

We don't have the capacity to vaccinate the whole world every 6 months.

I would imagine we'd have the capacity to make as many vaccines as someone will pay for. Yes the factories have to be ramped up but that can be done quickly enough. If those low to middle income countries were offering big bucks for vaccines, the vaccine makers would have just put more resources on it. The only reason it might make sense that we should stop boosting because it is taking them away from people who need…

"as many as someone will pay for" doesn't contradict "we don't have the capacity". This is a capital allocation problem and dedicating 100% of the world gdp to vaccine production will not improve our overall health and prosperity.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#250
post #12

Then they just rush-approve the mRNA vaccines with the modified payloads for Omicron and possibly Delta. The same delivery systems, merely different mRNA sequences, so I would think there's reasonable chance the (side)effects are the same. I thought this is already happening on the normal timeline. And there's a whole lot of vaccines coming on line that use different delivery systems and/or targets. There's a chance…

If you're ok with putting something in your body that has a "reasonable chance" of not harming you, why not just make it the actual virus?
Post reply on HN