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Israel Finds Fourth Covid Booster Is Ineffective

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Re: Israel Finds Fourth Covid Booster Is Ineffective

#41
I was thinking about immunity generally, from a Shannon information theory perspective. It's impossible that the human body has an infinite ability to absorb immunity, because otherwise we could store an infinite amount of information. Therefore, there must be some kind of forgetting that happens. Likewise, the body can only learn so much from repeated exposure.

Is anyone aware of any writing that explains immunity from an information theory perspective?

Re: Israel Finds Fourth Covid Booster Is Ineffective

#42
I'm curious about the argument that giving too many boosters takes away the vaccine from "people in low and middle-income countries."

Surely we have the capacity to make enough vaccines for everyone by now. It's just a matter of economics. Giving more boosters really shouldn't reduce supply, if there is money to make vaccines for everyone in the lower income countries, they will be made.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#43
post #23

Earlier quoted context omitted.

I can't for the life of me understand why your last statement isn't what the world is driving for at the moment. mRNA vaccines are easily(-ish) updated, so punch out an Omicron specific dose and get on with the regular single/dual (if needed) regime. It seems strange we'd opt for 3-4-5 shots given the benefit of mRNA was its ease of creation and modification.

I think they are making these strain specific boosters. But it seems “they”* want to keep it quiet until they are ready to release them. My first through on this is that there is over-supply of the OG vaccine and it takes time to switch production and the booster story is designed to give some hope and confidence to the masses (which is good I think). There is also some paperwork involved which takes time, but as we…

> I think they are making these strain specific boosters. But it seems “they” want to keep it quiet until they are ready to release them.

There's nothing quiet about it - Moderna has already publicly announced[1] that they're nearly ready to take their Omicron booster to clinical trials.

1. https://www.reuters.com/business/healthcare-pharmaceuticals/...

Re: Israel Finds Fourth Covid Booster Is Ineffective

#44
Something is not right. CNN reported the same study, with contradictory quotes from the same doctor:

Fourth vaccine dose boosts antibodies, researchers say, but likely not enough to prevent Omicron breakthrough infections http://lite.cnn.com/en/article/h_69134b5be555abcb7c1609154ab...

--- healthpolicy-watch.news ----- According to Regev-Yochay, the third dose resulted in “much higher antibodies, neutralization and the antibodies were not just higher in quantity but also in quality” than the second dose – but the fourth vaccine did not show significant antibody increase.

”Maybe there are a few more antibodies but not much more compared to the third dose,” said Regev-Yochay. -----

--- cnn.com ----- "We have a follow-up of the Pfizer vaccine for two weeks now, and we have a follow-up of the Moderna vaccine just for one week at this time point. And what we see is that the Pfizer vaccine, after two weeks, you see an enhancement or increase in the number of antibodies and neutralizing antibodies -- a pretty nice increase. It's even a little bit higher than what we had after the third dose," Regev-Yochay said. -----

Re: Israel Finds Fourth Covid Booster Is Ineffective

#45

If I understand correctly, israel mandates a third shot (to do normal stuff), as do many places in north america, either now or soon. And I can only imagine many people would be happy to mandate a fourth as soon as possible. What I find most frustrating is that politicians are happy to make these mandates live, during an ongoing situation where we actually don't know a lot about how effective things are (and in the c…

> When was the last time anyone actually trusted a government? My feeling is that people trust the government to the extent it does things their perceived enemies dislike. It's not about evaluating what's good for yourself or others; just knowing that your enemy dislikes it is a good enough signal that it's the right thing to do. Also, if your perceived enemy likes something that happens, that means it was automatica…

When considering how much power the federal government should ideally have, it’s wise to always remember that: one day, a party that you dislike will wield that power. Don’t think about what good you could do with all that power (because you’ll likely undershoot your positive intent anyway), but think about what bad someone who thought the opposite of what you want could do. It’s easier to destroy things than to build then up, so even if they also undershoot their positive intent, they can likely deliver on the things you’d find negative.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#47

If I understand correctly, israel mandates a third shot (to do normal stuff), as do many places in north america, either now or soon. And I can only imagine many people would be happy to mandate a fourth as soon as possible. What I find most frustrating is that politicians are happy to make these mandates live, during an ongoing situation where we actually don't know a lot about how effective things are (and in the c…

If they don't mandate, people will die. If they do mandate, potentially less people will die. By mandating before there's some kind of irrefutable proof that it'll help, they're saying that saving people's lives is worth any social or economic headache.

Also: your government is, I take it, some form of representative democracy? Saying you don't trust the government is identical to saying you don't trust the people of your nation. My suggestion is to try to fix that rather than just accept it blithely.

edit: Haha, I love how quickly I get downvoted for giving rational views of cost/benefit and politics.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#49

If I understand correctly, israel mandates a third shot (to do normal stuff), as do many places in north america, either now or soon. And I can only imagine many people would be happy to mandate a fourth as soon as possible. What I find most frustrating is that politicians are happy to make these mandates live, during an ongoing situation where we actually don't know a lot about how effective things are (and in the c…

a) Billions of doses of vaccines have been administered. We know a lot about their effectiveness.

b) Current vaccines with a booster are effective at preventing hospitalisations. It is enough to get the world through Omicron but special vaccines maybe useful for those who are immuno-compromised.

c) Children have been forced to take vaccines for decades. It's not new.

d) People trust their government every day. Who do you think builds the roads, operates the hospitals and other essential services, sets out safety regulations etc.

Re: Israel Finds Fourth Covid Booster Is Ineffective

#50
post #36

If I understand correctly, israel mandates a third shot (to do normal stuff), as do many places in north america, either now or soon. And I can only imagine many people would be happy to mandate a fourth as soon as possible. What I find most frustrating is that politicians are happy to make these mandates live, during an ongoing situation where we actually don't know a lot about how effective things are (and in the c…

If you’re in the US, the federal vaccine mandate was quashed by the Supreme Court, so no need to be terrified.

It was a weak decision. They allowed the CMS mandate to stand which provides the government yet another back door to coerce the population.
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