System76 should build a Rust GUI framework. I can't think of many other companies that are better positioned than them.
Doesn't seem like there'd be any good reason to do it. Gtk4 has great low and high level bindings in the form of gtk-rs and relm.
I, for one, would love to see someone fork GTK3 for desktop purposes. GTK4's development has almost entirely been predicated by the GNOME team (despite how hard they deny it), and additions like libadwaita has made GTK unusable for many. After Pop_OS! was publically harassed by the GNOME team, I kinda expected them to take that project up. I can settle for a desktop fork all the same though.