Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
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Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#2Yesterday's discussion: https://news.ycombinator.com/item?id=29901799
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#3They're showing inhibition at 100 ug/ml, but it looks like high doses result in serum CBDA concentrations in the low 100s of ng/ml [1].
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#4Note that they are talking about CBGa and CBDa. While these are present in whole flower and some concentrates, heating it up for vaporization or combustion leads to decarboxylation meaning you’ll be ingesting CBD and CBG.
Can’t wait for more research. Anyone wanting to act on this should go for non baked edibles such as tinctures.
Since 2018, a lot of these products are actually legally available online in most of the States.
Check the Certificate of Authenticity to see the tested levels of CBDa and CBGa.
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#5Now South Park makes sense.
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#6I did't know anything about the journal. I must admit, that something titled "Journal of Natural Products" didn't inspire much confidence. But it does look like it has been around for quite a long while, and has a respectable impact factor for a specialized journal too.
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#7This reminds me of William S Burrough’s “Cities of the Red Night,” in which a deadly plague appears suddenly. The character Dr. Pierson is a heroin addict, and helps discover that heroin is prophylactic against the fever:
“A top government official bluntly warned: ‘Virus B-23 now loose in our overcrowded cities, is an agent that produces biologic changes in those affected – fatal in many cases, permanent and hereditary in those who survive and become carriers for that strain, which as a matter of survival they will spread as far and fast as possible to destroy enemies and quite literally make friends.’ Junkies, however, are only lightly affected by the virus and remain characteristically unchanged.
…
“He recovers in the fear because of his addiction, and the word went out that the junk was the only insurance against the fever. No stemming the black market the Government concedes and legalises. Now begins a deadly war to extermination between the junkies and the fever-freaks.”
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#8No post body was provided.
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#9Now South Park makes sense.
It wasn't Randy's "secret ingredient" that healed people, it was the Tegridy product itself! Brilliant.
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#10I did't know anything about the journal. I must admit, that something titled "Journal of Natural Products" didn't inspire much confidence. But it does look like it has been around for quite a long while, and has a respectable impact factor for a specialized journal too.
It's a pharmacognosy journal: not crank/fringe at all. (Pharmacognosy is the study of drugs of natural origin -- about half our small molecule pharmaceuticals are either extracted from or synthetic but based on modifications of drugs of botanic origin.)