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U.S. surgeons transplant pig heart into human patient

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Re: U.S. surgeons transplant pig heart into human patient

#201

Reminder: We've been replacing human heart VALVES with pig valves for a long time now. My grandmother lived for almost a decade after her replacement. https://www.heart-valve-surgery.com/learning/pig-valve-repla...

I could be wrong but I believe those valves are harvested for their cartilagenous (non-alive) components, their cells stripped, the valves throughly cleaned, and implanted in place. This is not quite the same as implanting an organ with live cells autonomously producing potential antigens on a daily basis

Would artificial valves then not work as well or even better?

Re: U.S. surgeons transplant pig heart into human patient

#202
post #114

Earlier quoted context omitted.

I imagine Muslims, Jews, and Hindus would tend to have specific preferences as well.

I'd argue that in islam pretty much all of these restrictions are not applicable when it's for medical reasons. Alcohol is explicitly allowed in such cases (I think it was used to relieve pain in surgeries) , and even pork is okay to eat if you can't find anything else. Another example would be Ramadan fasting, which is not necessary if you are ill or when you are travelin. Overall, almost any restriction in islam is…

Is it allowed for all medical reasons, or if there's a genuine alternative would Islam dictate going for that instead?

Re: U.S. surgeons transplant pig heart into human patient

#203
post #114

Earlier quoted context omitted.

I imagine Muslims, Jews, and Hindus would tend to have specific preferences as well.

I'd argue that in islam pretty much all of these restrictions are not applicable when it's for medical reasons. Alcohol is explicitly allowed in such cases (I think it was used to relieve pain in surgeries) , and even pork is okay to eat if you can't find anything else. Another example would be Ramadan fasting, which is not necessary if you are ill or when you are travelin. Overall, almost any restriction in islam is…

I wish you were right. We got scolded for using donors’ breast milk for our newborn because donors might have eaten pork. SMH.

EDIT: I understand where you are coming from. I follow the most liberal and rational interpretation of Islam. But feel like we are very small minority.

Re: U.S. surgeons transplant pig heart into human patient

#204
post #155

Earlier quoted context omitted.

I'd argue that in islam pretty much all of these restrictions are not applicable when it's for medical reasons. Alcohol is explicitly allowed in such cases (I think it was used to relieve pain in surgeries) , and even pork is okay to eat if you can't find anything else. Another example would be Ramadan fasting, which is not necessary if you are ill or when you are travelin. Overall, almost any restriction in islam is…

You can rationalize all you want, but you can't reason religious people out of things they didn't reason themselves into. If these people can be convinced that they shouldn't be doing thing XYZ on the order of an omnipotent being that nobody has ever seen, chances seem to be even between them accepting exceptions from this order and them rejecting these exceptions. After all, you see other people rejecting/ignoring o…

It's not unknown for religions to explicitly set the preservation of life above other rules, eg in Judaism:

https://en.wikipedia.org/wiki/Pikuach_nefesh

Re: U.S. surgeons transplant pig heart into human patient

#205
post #61
post #26

You might be asking, why a pig? I don't know, but forever ago I wrote software for a cardiovascular imaging lab and pigs were their primary test subjects. I was like, "why pigs?" and the PI was like, "Imaging-wise, pig hearts aren't too different from humans. Plus, we can give them a heart attack in the scanner and not go to jail. Some labs use dogs. I just can't do that."

Pigs are really common in biomedical testing. They are physically a similar size and weight to humans. They also reach maturity in about 6 months. Much cheaper to raise than primates, and more likely to get approval for testing. My friends in biomed grad school named one of theirs cyber pig because it has about 30 different experiments ran on it before it was killed, and afterwards it was portioned out for further te…

If they reach maturity in 6 months only then might it make sense to create humanized pigs (with crucial genes replaced by human DNA) that are cultivated specifically for their organs? Fairly cruel I know, but these pigs would be treated better than pigs cultivated for meat, that's for sure.

Re: U.S. surgeons transplant pig heart into human patient

#206
post #121

Earlier quoted context omitted.

Weird to have a a scientist behaving so irrationally regarding pigs vs dogs, especially because the pig was chosen for its likeness to a human.

People have co-evolved with dogs as companions for a long time. And many people have fond memories of dogs and experience with them as part of a family. This is not generally true of pigs even if their hearts are closer to ours. Even as someone who doesn't like dogs, I find the idea of harming one (even with a good reason) worse than harming a pig.

Pigs are more intelligent and equally social. Humane society says they're as smart as 3 year old children. [1] Apparently tests show they've got about the same problem solving skills as chimps.

[1] https://www.humanesociety.org/animals/pigs

Re: U.S. surgeons transplant pig heart into human patient

#207
post #61

Earlier quoted context omitted.

Pigs are really common in biomedical testing. They are physically a similar size and weight to humans. They also reach maturity in about 6 months. Much cheaper to raise than primates, and more likely to get approval for testing. My friends in biomed grad school named one of theirs cyber pig because it has about 30 different experiments ran on it before it was killed, and afterwards it was portioned out for further te…

If they reach maturity in 6 months only then might it make sense to create humanized pigs (with crucial genes replaced by human DNA) that are cultivated specifically for their organs? Fairly cruel I know, but these pigs would be treated better than pigs cultivated for meat, that's for sure.

Go read "Oryx and Crake"

Re: U.S. surgeons transplant pig heart into human patient

#208
post #151

Genuine question: why is an artificial heart such a hard thing to make? At least from a lay-person's perspective, it's just some pumps and valves, which we've gotten pretty good at making. Obviously I'm wrong about that because there really isn't a permanent artificial heart yet, but it's something I have wondered for awhile.

See "total artificial heart": https://en.wikipedia.org/wiki/Artificial_heart Layperson speculation: hard to power 24/7 without an external power source, it must connect seamlessly to the blood stream (can't have it disconnect from the aorta after five weeks), and the surfaces exposed to the blood must not cause blood clots (so careful at the seams).

It does make me wonder how the transplanted pig heart or any transplanted heart connects so seamlessly.

The issue simply heals and grows together with the foreign tissue?

Re: U.S. surgeons transplant pig heart into human patient

#209
post #26

You might be asking, why a pig? I don't know, but forever ago I wrote software for a cardiovascular imaging lab and pigs were their primary test subjects. I was like, "why pigs?" and the PI was like, "Imaging-wise, pig hearts aren't too different from humans. Plus, we can give them a heart attack in the scanner and not go to jail. Some labs use dogs. I just can't do that."

> "Imaging-wise, pig hearts aren't too different from humans. Plus, we can give them a heart attack in the scanner and not go to jail. Some labs use dogs. I just can't do that."

I wonder if they'd feel differently if they thought about how pigs are more intelligent than dogs.

Re: U.S. surgeons transplant pig heart into human patient

#210

Earlier quoted context omitted.

No reason to gloat. Yea, I eat them too, but not proud of my actions.

Not gloating. I genuinely enjoy eating pork and meat in general. It's the most nutritious food a human can eat in my humble opinion. I hold no shame in eating and enjoying meat. If I was a scientist and a piggie died as part of an experiment or whatever. I would do my best to eat the piggie and not let any part of it end up in the trash and going to waste.

> It's the most nutritious food a human can eat in my humble opinion.

Citation needed on this one. I'm curious.

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