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U.S. surgeons transplant pig heart into human patient

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Re: U.S. surgeons transplant pig heart into human patient

#71
post #26

You might be asking, why a pig? I don't know, but forever ago I wrote software for a cardiovascular imaging lab and pigs were their primary test subjects. I was like, "why pigs?" and the PI was like, "Imaging-wise, pig hearts aren't too different from humans. Plus, we can give them a heart attack in the scanner and not go to jail. Some labs use dogs. I just can't do that."

I heard they are humanized 'pigs'. Ie. engineered so their organs don't trigger our immune system. Not sure how true is this, or it is just a myth.

Re: U.S. surgeons transplant pig heart into human patient

#73
post #71
post #26

You might be asking, why a pig? I don't know, but forever ago I wrote software for a cardiovascular imaging lab and pigs were their primary test subjects. I was like, "why pigs?" and the PI was like, "Imaging-wise, pig hearts aren't too different from humans. Plus, we can give them a heart attack in the scanner and not go to jail. Some labs use dogs. I just can't do that."

I heard they are humanized 'pigs'. Ie. engineered so their organs don't trigger our immune system. Not sure how true is this, or it is just a myth.

The article states they changed a sugar that triggered rejection.

Re: U.S. surgeons transplant pig heart into human patient

#74
post #51

Earlier quoted context omitted.

They’re not making the pig more human, they’re removing the markers of ‘foreign’ that would make it an immune target. So it’s a nice vanilla organ that minimally attracts the attention of the immune system.

On the other hand (and I am being flippant... Slightly) how do you know that removing this one gene doesn't unlock consciousness?

I'd definitely think of pigs conscious given they can play video games: https://www.bbc.com/news/technology-56023720

Re: U.S. surgeons transplant pig heart into human patient

#75

When I was a teenager there was a novel adapted for TV by the BBC called “Pig Heart Boy”. It explored the emotional impact of this type of procedure on a teenager and the response from the public, both good and bad. I don’t remember much about it but it looks like it won a BAFTA. https://en.m.wikipedia.org/wiki/Pig_Heart_Boy

"Pig Heart Boy (1999)" https://youtu.be/JoBW_XCWDDA

Re: U.S. surgeons transplant pig heart into human patient

#76
post #71
post #26

You might be asking, why a pig? I don't know, but forever ago I wrote software for a cardiovascular imaging lab and pigs were their primary test subjects. I was like, "why pigs?" and the PI was like, "Imaging-wise, pig hearts aren't too different from humans. Plus, we can give them a heart attack in the scanner and not go to jail. Some labs use dogs. I just can't do that."

I heard they are humanized 'pigs'. Ie. engineered so their organs don't trigger our immune system. Not sure how true is this, or it is just a myth.

Careful with that. You might end up with pigoons [1]

[1] https://en.wikipedia.org/wiki/Oryx_and_Crake

Re: U.S. surgeons transplant pig heart into human patient

#77

I wonder why an artificial heart wasn't an option here.

Other places that are reporting on him say "He was deemed ineligible for an artificial heart pump due to uncontrollable arrhythmia."

I jumped onto Wikipedia to figure out why arrhytmia might be a problem, and it looks like "artificial heart pump" might stand for a VAD (Ventricular Assist Device), as in it pumps blood and it helps, but the original organ remains in circuit.

Re: U.S. surgeons transplant pig heart into human patient

#79

The pig life expectancy is about 12-18 years. Does it mean that the heart will work about so long?

Not necessarily. Life expectancy is affected by the most mortal part of your species: it might be that pigs’ hearts are fine, but they’re prone to cancers after a certain age.

Re: U.S. surgeons transplant pig heart into human patient

#80
post #51

Earlier quoted context omitted.

They’re not making the pig more human, they’re removing the markers of ‘foreign’ that would make it an immune target. So it’s a nice vanilla organ that minimally attracts the attention of the immune system.

On the other hand (and I am being flippant... Slightly) how do you know that removing this one gene doesn't unlock consciousness?

> how do you know that removing this one gene doesn't unlock consciousness?

The words you're looking for are sentience or even sapience.

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