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Experimental depression treatment is nearly 80% effective in controlled study

med.stanford.edu

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Re: Experimental depression treatment is nearly 80% effective in controlled study

#81
post #6

There are surely enough trials on depression per year that a result with 15 participants in the treatment group is to small to start bringing this to public attention? With a sample size this small I don't think it should be in the news at all

It’s already a well established treatment, this is just the accelerated form, confirming it still works.

Accelerated, with fine tuning of targeting. It seems it may work much better.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#82
post #59
post #57

“I don’t procrastinate anymore,” he added. “I’m sleeping better. I completely quit alcohol. I’m walking my dog and playing the guitar again, for nothing more than the sheer joy of it.” Most importantly, he said, “I’m remaining positive and being respectful of others. These are big changes in my life.” Serious question: are these typical signs of depression? Now I'm wondering if I have depression.

Anecdotally, the lack of those things are definitely present in myself when I'm experiencing a depressive episode (I am diagnosed with clinical depression): I sleep badly, either not at all or for 12-18 hours a day, I drink far too much, I do not leave my house, and my hobbies either fall by the wayside entirely or I partake in them with no enjoyment or happiness from it. If you're experiencing those, it might be wor…

Noticed that both you and the OP mentioned drinking. Just the drinking can cause much of this. Drinking screws up your sleep cycle, which can also cause much of this. Drinking sessions are also time consuming, so you have less time for other things you enjoy anyway. Sure, some things you can do while drinking, but those may not be the things you would prefer to be doing while sober.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#84
post #33
post #20

Earlier quoted context omitted.

This is a great comment. I've always been a little uncomfortable with the thought of this magnetic treatment in a way I couldn't put into words and this nails it. I'm willing to trust, perhaps naively, that everyone is getting the same Prozac tablets. But how does the skill of the practitioner and maintenance of their magnetic treatment device affect outcomes? It's almost like a surgery, but I'm not sure who's actual…

A whole lot of treatments end up refined with time. The FDA approved treatment is "aim at the middle of the dorsolateral prefrontal cortex". Getting more activity and connectedness improves its regulation of overall emotional activity. This research implies that aiming instead slightly differently and a different dosing regimen may be more effective. This is no different from any other medical treatment, where we fin…

Yes. Treatments are simply implementations of science technology at a particular time.

To get some perspective on iterations of treatment, read this account of the work of August Bier.

He pioneered spinal anesthesia, something used all of the time today for epidurals during childbirth.

His experimental treatments he both performed and had performed on him by his assistant will, at the very least, raise your eyebrows.

https://en.wikipedia.org/wiki/August_Bier#Spinal_anesthesia

Re: Experimental depression treatment is nearly 80% effective in controlled study

#85
Years ago I found the video by Dr. Robert Sapolsky[1] to be a good introduction to the topic of depression. I also suffered a major depression of my own about six years ago. It was a horrible time in my life.

[1] https://www.youtube.com/watch?v=NOAgplgTxfc

Re: Experimental depression treatment is nearly 80% effective in controlled study

#87
I'm surprised nobody's linked to the recent time this was on HN [1].

Having tried TMS pretty extensively, I do not think this will help me, but I am hopeful that it might prove useful for others.

[1] - https://news.ycombinator.com/item?id=29562785

Re: Experimental depression treatment is nearly 80% effective in controlled study

#89
post #26

I've been dealing with depression for over 15 years. I can only hope that this becomes available to the masses.

If you haven't had results from medication, there are a couple of new drugs on the market now that are indicated for treatment resistant depression.

Have any details? I have a close friend with treatment resistant depression.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#90

> “The treatment, known as Stanford accelerated intelligent neuromodulation therapy (SAINT) or simply Stanford neuromodulation therapy, is an intensive, individualized form of transcranial magnetic stimulation. In the study, remission typically occurred within days and lasted months. The only side effects were temporary fatigue and headaches.” > “Twenty-nine people with treatment-resistant depression participated in…

>>In contrast, only two of the 15 participants who had received the placebo met the criteria for remission.
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