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Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

medrxiv.org

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Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#61
post #14

An animal study found that aspiration during injection could reduce the risk of vaccine induced myocarditis. It hasn't been reproduced in humans but this seems like something worthy of further research. https://academic.oup.com/cid/advance-article/doi/10.1093/cid...

Why would the aspiration risk be significantly different between the two mRNA vaccines?

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#62

Earlier quoted context omitted.

No. 3rd dose Pfizer is not statistically significantly worse than infection for myocarditis.

Am I missing something obvious? Am I reading too much from the error bars in the Incidence Rate Ratio charts? Or did I misinterpret the charts some other way?

In the chart, the IRR from infection is 2.02, 95% CI 1.13-3.61. The IRR for 3rd dose Pfizer is 7.6, 95% CI 1.92-30.15.

Because the confidence interval of the Pfizer 3rd dose contains the datapoint for infection, there is a pretty good chance that the 3rd dose is not anymore likely to lead to myocarditis than COVID, and the result isn't statistically significant at p<=0.05. We can't say for sure.

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#63

Wow, I just got the Pfizer booster a few days ago and I'm an under-40 male who has previously had pericarditis... I was worried about the risk being greater than the reward for my age group but didn't have the age-stratified data to prove it. Kind of regretting it now, especially since I only got it at the urging of my wife. I just needlessly increased the odds of a giving myself a heart issue for absolutely no reaso…

Your overall odds of death from covid went down. And as I understand it, myocarditis often goes away on its own or can be treated at home.

> myocarditis often goes away on its own

I was under the impression myocarditis was when some heart tissue died and doesn't recover.

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#64
post #16

Earlier quoted context omitted.

Over the long run your risk of catching a SARS-CoV-2 infection approaches 100%. The virus can never be eradicated and we'll all be exposed to it occasionally. Vaccination — and other measures to strengthen your immune system — can reduce the risk of serious COVID-19 symptoms to fairly low levels. https://www.medpagetoday.com/opinion/vinay-prasad/94646

The risk of serious COVID-19 symptoms are already at quite low levels in the < 40 male group.

Yes, and WAY higher than the risk of serious symptoms for the virus. For males 18-29 the risk of hospitalization is 0.4% compared to 0.1% for myocarditis, and most myocarditis cases do not require hospitalization. Risk of severe disease is of course much more than risk of hospitalization.

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#65
post #36

Earlier quoted context omitted.

The fact the CDC recognizes myocarditis results from infection of vaccination does not support your claim that it is a direct result of "spike protein saturating the body". It is an immune response, not a direct effect of the protein. If it was a response to the protein, it wouldn't occur primarily after the second dose of Moderna, it would occur with equal likelihood after both first and second doses.

I don't understand what you're defending against. The science proves you wrong. The inflammatory response is primarily triggered by the [1] spike protein. "We observed that spike (S) protein potently induces inflammatory cytokines and chemokines including IL-6, IL-1β, TNFα, CXCL1, CXCL2, and CCL2" I'm curious to see the fuller data set on adolescent males since it does seem initially that moderna may be more likely t…

Well, yes, the spike protein induces an immune response. That's the entire purpose of using it as an antigen in a vaccine. If you don't see the daylight between that and your original claim that 'saturating the body with spike protein' which gets uptaken in tissue in the heart as metabolic substrate which then results in myocarditis, I don't know what to say.

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#66
post #54

Earlier quoted context omitted.

Is r/lockdownskepticism also skeptical of vaccination? And do you think covid is worse than or same as the flu?

> Is r/lockdownskepticism also skeptical of vaccination? It's a very heterogenous sub, but I don't think you'll find the kind of anti-vax thinking that suggests that, eg, childhood vaccination is unhelpful to a society, if that's what you're asking. If you are asking more strictly about sentiment toward the currently available SARS-CoV-2 vaccines, I think that by and large we think they're a marvel of engineering, bu…

No post body was provided.

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#67
post #44

Earlier quoted context omitted.

You are asking when in history we vaccinated to prevent infectious disease induced morbidity?

When have we vaccinated to prevent infectious disease induced side effects excluding morbidity.

> When have we vaccinated to prevent infectious disease induced side effects excluding morbidity.

Whenever we vaccinate to prevent mortality; generally we vaccinate to mitigate both morbidity and mortality from a disease.

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#68

Earlier quoted context omitted.

Who says the vaccine prevents heart complications from infection? All the statistics I’ve seen compare mainly mortality. From a pure risk vs reward of vaccine vs no vaccine, measuring mortality seems reasonable. When in history have we vaccinated to prevent side effects?

So what is the mortality rate of the vaccine? Because this is the myocarditis rate, and the vast majority of cases didn't even require hospitalization. If you want to compare mortality rates, share a link. And yes, the virus prevents heart complications from infection, because it prevents symptomatic infection.

It’s pretty evident at this point it doesn’t prevent symptomatic infection.

Death rate on both is close to 0. My point is if the vaccine doesn’t prevent infection (protecting other people) the vaccine risk vs reward is negligible for this age group. It should be purely up to the person to make their own decision. Not anyone else’s. Treat it like the flu shot.

I was vaccinated when I saw 90% at preventing infections, but now that’s been disproven I’ll call it how I see it. I’m moving on.

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#69

Earlier quoted context omitted.

There is a definite overlap in people skeptical of lockdowns and the vaccines, but the sub tries to steer clear of vaccine skepticism due to it being technically off topic, and something that would get the sub nuked. Not that you asked me- I would classify it as "different" than the flu, that it affects different individuals differently, and that the original variant was definitely something more scary than the flu.…

Quoted post unavailable.

> given the rate of deaths are 10-20x worse than the worst flu years.

I have a hard time accepting this premise. Mostly because the flu was somehow eradicated at the outset of mass covid testing, many of the covid tests did not distinguish between the flu and covid. Furthermore, I believe that we actually responded to covid in a way that caused excess covid deaths by over counting deaths and actively suppressing unpatentable treatments for covid. I think we hospitalized people that didn't need to be hospitalized, and we told people not to do anything until they needed to be hospitalized. We then started putting too many people on vents, giving them Remdesiver(toxic with highly questionable efficacy), and putting covid patients in nursing homes with the most vulnerable population. Not to mention lockdowns that pushed a huge portion of the world into poverty, nutritional deficiency, and much more susceptible to adverse effects from disease as a result.

But those are just my thoughts- I don't think we have good enough data, nor will we ever- to actually make strong conclusions either way.

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#70
post #63

Earlier quoted context omitted.

Your overall odds of death from covid went down. And as I understand it, myocarditis often goes away on its own or can be treated at home.

> myocarditis often goes away on its own I was under the impression myocarditis was when some heart tissue died and doesn't recover.

It's inflammation of the heart muscle.

https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/my...

There is a wealth of info about this known condition on the web including symptoms and treatment. If you have concerns, ask your GP, they're there to help you.

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